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Featured Last Updated Sep 19 2025, 12:25 PM

NFL: Rams vs. Eagles, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Rams vs. Eagles, Prediction, Odds, Best Bet

Featured Image Credit: Jay Biggerstaff via Imagn Images

LA @ PHI Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Los Angeles Rams 461 Rams
+4.5 -105 +2.5 -110 + +2.5 -110 + +1.5 -108 + +2.5 -110 + +2.5 -115 + +2.5 -110 + +1.5 even +1.5 -113 + +1.5 -113 +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 -2.5 -110 + -2.5 -110 + -1.5 -112 + -2.5 -110 + -2.5 -115 + -2.5 -110 + -1.5 -120 -1.5 -110 + -1.5 -110 -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o21.5 -120 + N/A o22.5 -110 + o21.5 -120 + N/A o22.5 -125 + o22.5 -110 o22.5 -125 + o22.5 -125 o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u21.5 even + N/A u22.5 -110 + u21.5 even + N/A u22.5 +105 + u22.5 -110 u22.5 +102 + u22.5 +102 u44.5 -110  
Los Angeles Rams 461 Rams
+170 +135 + N/A +130 + +135 + +125 + +130 + +130 +123 + +123 +154  
Philadelphia Eagles 462 Eagles
-205 -160 + N/A -155 + -160 + -160 + -160 + -160 -155 + -155 -185  
Los Angeles Rams 461 Rams
+4.5 -105 +0.5 -140 + +0.5 -160 + +0.5 -148 + +0.5 -150 + +0.5 -150 + +1.5 -150 + +1.5 -165 +1.5 -159 + +1.5 -159 +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 -0.5 +120 + -0.5 +125 + -0.5 +124 + -0.5 +120 + -0.5 +120 + -1.5 +124 + -1.5 +120 -1.5 +128 + -1.5 +128 -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o7.5 +110 + N/A o7.5 +110 + o7.5 +105 + o7.5 +105 + o7.5 -106 + o8.5 even o7.5 even + o7.5 even o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u7.5 -130 + N/A u7.5 -130 + u7.5 -135 + u7.5 -135 + u7.5 -116 + u8.5 -135 u7.5 -122 + u7.5 -122 u44.5 -110  
Los Angeles Rams 461 Rams
+170 +115 + N/A +110 + +110 + +105 + +118 + +105 +112 + +112 +154  
Philadelphia Eagles 462 Eagles
-205 -135 + N/A -130 + -140 + -135 + -144 + -140 -139 + -139 -185  
Los Angeles Rams 461 Rams
+4.5 -105 N/A N/A +0.5 -105 + +0.5 -110 + N/A +1.5 -124 + N/A N/A N/A +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 N/A N/A -0.5 -115 + -0.5 -110 + N/A -1.5 +102 + N/A N/A N/A -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o13 -115 + N/A o13.5 -105 + o13.5 -105 + N/A o13.5 -116 + N/A N/A N/A o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u13 -105 + N/A u13.5 -115 + u13.5 -115 + N/A u13.5 -106 + N/A N/A N/A u44.5 -110  
Los Angeles Rams 461 Rams
+170 +130 + N/A +130 + +125 + N/A +122 + N/A N/A N/A +154  
Philadelphia Eagles 462 Eagles
-205 -155 + N/A -155 + -145 + N/A -150 + N/A N/A N/A -185  
Los Angeles Rams 461 Rams
+4.5 -105 N/A N/A +0.5 -125 + +0.5 -125 + N/A +1.5 -154 + N/A N/A N/A +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 N/A N/A -0.5 +105 + -0.5 +105 + N/A -1.5 +126 + N/A N/A N/A -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o9.5 -110 + N/A o9.5 -115 + o9.5 -110 + N/A o9.5 -110 + N/A N/A N/A o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u9.5 -110 + N/A u9.5 -105 + u9.5 -110 + N/A u9.5 -110 + N/A N/A N/A u44.5 -110  
Los Angeles Rams 461 Rams
+170 +120 + N/A +130 + +120 + N/A +110 + N/A N/A N/A +154  
Philadelphia Eagles 462 Eagles
-205 -140 + N/A -155 + -140 + N/A -134 + N/A N/A N/A -185  
Los Angeles Rams 461 Rams
+4.5 -105 +0.5 -130 + N/A +0.5 -118 + +0.5 -115 + N/A +1.5 -146 + N/A N/A N/A +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 -0.5 +110 + N/A -0.5 -102 + -0.5 -105 + N/A -1.5 +120 + N/A N/A N/A -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o13 -105 + N/A o13.5 +105 + o12.5 -120 + N/A o12.5 -116 + N/A N/A N/A o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u13 -115 + N/A u13.5 -122 + u12.5 even + N/A u12.5 -106 + N/A N/A N/A u44.5 -110  
Los Angeles Rams 461 Rams
+170 +110 + N/A +120 + +115 + N/A +108 + N/A N/A N/A +154  
Philadelphia Eagles 462 Eagles
-205 -130 + N/A -142 + -135 + N/A -132 + N/A N/A N/A -185  
Los Angeles Rams 461 Rams
+4.5 -105 +1.5 -120 + N/A N/A +0.5 -110 + N/A +1.5 -120 + N/A +1.5 -117 + +1.5 -117 +3.5 -115  
Philadelphia Eagles 462 Eagles
-4.5 -115 -1.5 even + N/A N/A -0.5 -110 + N/A -1.5 -100 + N/A -1.5 -107 + -1.5 -107 -3.5 -105  
Los Angeles Rams 461 Rams
o46.5 -110 o21.5 -110 + N/A N/A o21.5 -115 + N/A o21.5 -115 + N/A o21.5 -109 + o21.5 -109 o44.5 -110  
Philadelphia Eagles 462 Eagles
u46.5 -110 u21.5 -110 + N/A N/A u21.5 -105 + N/A u21.5 -105 + N/A u21.5 -114 + u21.5 -114 u44.5 -110  
Los Angeles Rams 461 Rams
+170 +115 + N/A N/A N/A N/A +118 + N/A +118 + +118 +154  
Philadelphia Eagles 462 Eagles
-205 -135 + N/A N/A N/A N/A -138 + N/A -148 + -148 -185  

The Rams will take on the Eagles in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Lincoln Financial Field in Philadelphia, Pa. The game will be broadcast live on FOX. Here's everything you need to know about Rams vs. Eagles odds, the latest NFL spreads, NFL over/unders and more.

The Eagles opened as a -3.5 point favorite over Rams. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Los Angeles Rams vs. Philadelphia Eagles Best Bet

To say the Eagles' offense has looked lackluster out the gate would be an understatement.

They are averaging a meager 4.3 yards per play, a full 1.3 yards down from 2024. The Eagles have completed 5(!!) passes of 10+ air yards, good for dead last in football; the next closest team is at 14.

Through two weeks, the Rams' defense is 2nd in EPA/play and Success Rate. Although the opponents haven't been strong necessarily, young players like Jared Verse, Braden Fiske, and Kobie Turner along with the addition of Poona Ford should give the Eagles interior offensive line plenty of issues.

On the other side, the Eagles defense is the same dominant unit it was from a year ago. Although the second cornerback spot is a weakness, the Eagles' defensive line should more than make up for the Rams o-line.

I expect a slow-paced, ball-control game with lots of ground and pound from each side.

Rams vs. Eagles Best Bet: Under 44.5 (-105 on ESPN BET)

(Pick from Derek Mountain)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Los Angeles Rams vs. Philadelphia Eagles Game?

The Los Angeles Rams vs. Philadelphia Eagles at 1:00 ET on Sunday, September 21st.

Where is the Los Angeles Rams vs. Philadelphia Eagles Game Being Played?

This game will be played at Lincoln Financial Stadium in Philadelphia, PA.

How Can I Watch Eagles vs. Rams?

You can watch Eagles vs. Rams on FOX.

Can the Rams Beat the Eagles?

The Rams will look to seek revenge from last year's NFC Divisional Round Playoffs loss.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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