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Featured Last Updated Oct 17 2025, 10:26 AM

NFL: Rams vs. Jaguars, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Rams vs. Jaguars, Prediction, Odds, Best Bet

Featured Image Credit: Mitch Stringer via Imagn Images

LA @ JAC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Los Angeles Rams 451 Rams
-4.5 -110 -1.5 -105 + -1.5 even + -0.5 -115 + -1 -107 + -0.5 -120 + -1.5 +105 + -1.5 -105 + -0.5 -115 -1.5 even + -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 +1.5 -115 + +1.5 -120 + +0.5 -105 + +1 -114 + +0.5 -110 + +1.5 -125 + +1.5 -115 + +0.5 -105 +1.5 -124 + +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o22.5 -115 + N/A o21.5 -115 + o22.5 -108 + N/A o22.5 -115 + o22.5 -115 + o22.5 -115 o22.5 -121 + o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u22.5 -105 + N/A u21.5 -105 + u22.5 -111 + N/A u22.5 -105 + u22.5 -105 + u22.5 -105 u22.5 -103 + u44.5 -105  
Los Angeles Rams 451 Rams
-205 -135 + -140 + -135 + -136 + -140 + -130 + N/A -140 -132 + -166  
Jacksonville Jaguars 452 Jaguars
+170 +115 + +115 + +114 + +110 + +110 + +108 + N/A +115 +107 + +140  
Los Angeles Rams 451 Rams
-4.5 -110 -0.5 +125 + -0.5 +130 + -0.5 +136 + N/A -0.5 +130 + -1.5 +140 + -0.5 +130 + -0.5 +125 -1.5 +135 + -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 +0.5 -150 + +0.5 -165 + +0.5 -162 + N/A +0.5 -170 + +1.5 -172 + +0.5 -155 + +0.5 -170 +1.5 -175 + +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o7.5 even + N/A o7.5 +102 + N/A o7.5 even + o7.5 -102 + o7.5 even + o8.5 +105 o7.5 -103 + o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u7.5 -120 + N/A u7.5 -122 + N/A u7.5 -130 + u7.5 -120 + u7.5 -120 + u8.5 -140 u7.5 -121 + u44.5 -105  
Los Angeles Rams 451 Rams
-205 -135 + -120 + -118 + N/A -120 + -120 + N/A -125 -127 + -166  
Jacksonville Jaguars 452 Jaguars
+170 +115 + -102 + -102 + N/A -110 + -102 + N/A -105 +102 + +140  
Los Angeles Rams 451 Rams
-4.5 -110 -0.5 -110 + N/A -2.5 -110 + N/A N/A -1.5 -105 + N/A N/A -1.5 -103 + -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 +0.5 -110 + N/A +2.5 -110 + N/A N/A +1.5 -115 + N/A N/A +1.5 -122 + +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o22 -110 + N/A o22.5 -120 + N/A N/A o21.5 -110 + o22.5 -120 + N/A o21.5 -115 + o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u22 -110 + N/A u22.5 even + N/A N/A u21.5 -110 + u22.5 -110 + N/A u21.5 -108 + u44.5 -105  
Los Angeles Rams 451 Rams
-205 -130 + N/A -162 + N/A N/A -144 + N/A N/A -148 + -166  
Jacksonville Jaguars 452 Jaguars
+170 +110 + N/A +136 + N/A N/A +122 + N/A N/A +118 + +140  
Los Angeles Rams 451 Rams
-4.5 -110 N/A N/A -0.5 -105 + N/A N/A -1.5 +112 + -0.5 -105 + N/A N/A -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 N/A N/A +0.5 -115 + N/A N/A +1.5 -136 + +0.5 -125 + N/A N/A +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o13 -115 + N/A o13.5 +105 + N/A N/A o13.5 -110 + o13.5 -105 + N/A N/A o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u13 -105 + N/A u13.5 -125 + N/A N/A u13.5 -110 + u13.5 -125 + N/A N/A u44.5 -105  
Los Angeles Rams 451 Rams
-205 -140 + N/A -142 + N/A N/A -132 + N/A N/A N/A -166  
Jacksonville Jaguars 452 Jaguars
+170 +120 + N/A +120 + N/A N/A +108 + N/A N/A N/A +140  
Los Angeles Rams 451 Rams
-4.5 -110 N/A N/A -0.5 +102 + N/A N/A -1.5 +118 + -0.5 +105 + N/A N/A -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 N/A N/A +0.5 -122 + N/A N/A +1.5 -144 + +0.5 -135 + N/A N/A +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o9.5 -110 + N/A o9.5 -118 + N/A N/A o9.5 -110 + o9.5 -120 + N/A N/A o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u9.5 -110 + N/A u9.5 -102 + N/A N/A u9.5 -110 + u9.5 -110 + N/A N/A u44.5 -105  
Los Angeles Rams 451 Rams
-205 -130 + N/A -148 + N/A N/A -144 + N/A N/A N/A -166  
Jacksonville Jaguars 452 Jaguars
+170 +110 + N/A +124 + N/A N/A +118 + N/A N/A N/A +140  
Los Angeles Rams 451 Rams
-4.5 -110 -0.5 +115 + N/A -0.5 -108 + N/A N/A -1.5 +122 + N/A N/A N/A -3 -115  
Jacksonville Jaguars 452 Jaguars
+4.5 -110 +0.5 -135 + N/A +0.5 -112 + N/A N/A +1.5 -148 + N/A N/A N/A +3 -105  
Los Angeles Rams 451 Rams
o47.5 -110 o13 -110 + N/A o13.5 +105 + N/A N/A o12.5 -116 + o12.5 -130 + N/A N/A o44.5 -115  
Jacksonville Jaguars 452 Jaguars
u47.5 -110 u13 -110 + N/A u13.5 -125 + N/A N/A u12.5 -106 + u12.5 even + N/A N/A u44.5 -105  
Los Angeles Rams 451 Rams
-205 -120 + N/A -142 + N/A N/A -128 + N/A N/A N/A -166  
Jacksonville Jaguars 452 Jaguars
+170 even + N/A +120 + N/A N/A +104 + N/A N/A N/A +140  

The Rams will take on the Jaguars in this week's NFL action. Kickoff is set for 9:30 a.m. EDT at Wembley Stadium in London, England. The game will be broadcast live on NFL Network. Here's everything you need to know about Rams vs. Jaguars odds, the latest NFL spreads, NFL over/unders and more.

The Rams opened as a -3 point favorite over Jaguars. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/17/25

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Los Angeles Rams vs. Jacksonville Jaguars Best Bet

The Rams sure look like one of the best teams in the NFL, getting an excellent season from Matthew Stafford thus far despite the veteran sitting out most of camp with an injury. He grades out as the fifth-best passer according to Pro Football Focus, and with that, his offense has averaged eight yards per pass and ranks third with 6.1 yards per play on average.

This is a team that loves to throw the ball and has run wild on plenty of defenses in spite of a volatile run game. Well, the Jaguars have done a pretty good job of stopping the run, but their pass rush has been ineffective and the secondary continues to look like minced meat, serving up 295 yards to Sam Darnold last week on just 16-of-27 passing.

Even without Puka Nacua, I expect this excellent offense to survive, and on the opposite end, you'll never catch me dead believing in a Trevor Lawrence-led offense, particularly against a defense this strong.

Rams vs. Jaguars Best Bet: Rams -3

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Los Angeles Rams vs. Jacksonville Jaguars Game?

The Los Angeles Rams vs. Jacksonville Jaguars is at 9:30 AM ET on Sunday, October 19th.

Where is the Los Angeles Rams vs. Jacksonville Jaguars Game Being Played?

This game will be played at Wembley Stadium in London, England.

How Can I Watch Rams vs. Jaguars?

You can watch Rams vs. Jaguars on NFL Network.

Can the Jaguars Beat the Rams?

Yes, the theme of the 2025-26 NFL season to date has been there is not a dominant team out there. With the point spread under a field goal, the Vegas oddsmakers are expecting a close one in London.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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