New York Giants vs. Tennessee Titans Picks, Predictions, Odds

Week 1 of the NFL season will resume on Sunday afternoon with a non-conference matchup between the New York Giants and Tennessee Titans. Coverage begins at 4:25 p.m. ET on FOX.

Updated on 04/20/2024
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Tennessee won the AFC South with a record of 12-5 last season, which beat out the second-placed Colts by a three-game margin, and narrowly topped the Chiefs for the top seed in the conference, despite All-Pro RB Derrick Henry missing nine contests with a foot injury. On the flip side, the Giants finished dead-last in the NFC East with a record of 4-13 last season, marking New York’s fifth straight season with six or less wins. However, I’d go easy on the Giants to start the year, as they posted a modest 4-7 record in contests Daniel Jones participated in, compared to an ugly 0-6 mark in his absence; which, if Jones stayed healthy, would’ve put New York on track for its best campaign since 2016.

The Titans earned the top spot in the AFC despite averaging just 24.2 PPG last season, which ranked 14th in the league in scoring and trailed fringe playoff squads like Minnesota (25 PPG) and Philadelphia (25.5 PPG). However, the Titans’ defense significantly stepped up its game, as Tennessee surrendered just 20.6 PPG to its opponents throughout the year, which ranked sixth in the league in that department.

I’ll take the under here, as Tennessee’s passing game is expected to take a step back following the departure of top wideout A.J. Brown; but the Titans should still find some success on the ground against a New York defensive front ranked 22nd in yards allowed per rush attempt last season (4.5). So, we’ll probably see Tennessee win this one by overpowering the G-Men with its defense and rushing attack.

Score Prediction: Titans 24, Giants 16
Best Bet: Under 43.5 (-110)


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Date: Sunday, Sept. 11, 2022
Matchup: NFC East vs. AFC South
Venue: Nissan Stadium
Location: Nashville, Tennessee
Time-TV: FOX, 4:25 p.m. ET


The Giants finished last in the NFC East with a record of 4-13 last season, tying the Jets (4-13) for the third-worst mark in the league, with the only squads trailing in the standings being the Lions (3-13-1) and Jaguars (3-14).

Health issues were partly to blame for the Giants’ struggles, especially on the offensive side, highlighted by New York’s modest 4-7 record through the first 12 weeks of the season. However, Jones suffered a season-ending neck injury that completely derailed their campaign, leading to an ugly 0-6 skid down the homestretch.

Giants’ RB Saquon Barkley participated in 13 contests last season, which is tied for his career high since suiting up for all 16 games during his impressive Rookie of the Year campaign back in 2018. However, Barkley dealt with a lingering injury for most of last year; and the Giants’ 31st ranked offense didn’t exactly breed run-heavy scenarios often (15.2 PPG). So, I’d cut him some slack for inconsistent production (45.6 RYPG, 12.5 CAR).

The total has gone UNDER in five straight Titans' home games. (Getty Images)


The Titans cruised to an AFC South title with a record of 12-5 last year, which paced the Colts (9-8), Texans (4-13), and Jaguars (3-14) by a distant margin; and tied the Chiefs for the top spot in the conference. However, Tennessee’s 27-3 victory over Kansas City back in Week 7 ultimately served as the differentiating factor between the top two squads in the AFC.

Tennessee certainly hit a few roadblocks, as Titans’ All-Pro RB Derrick Henry missed nearly half of last year due to a foot injury, who’s absolutely crucial to the Titans’ identity on the offense.

However, their defense really stepped up last season, as the Titans finished the season ranked 6th in points allowed and 11th in total defense last season (20.7 PPG, 331 YPG), while their offense ranked just 14th in scoring and 17th in total yardage (24.2 PPG, 343 YPG); which is somewhat atypical for an AFC contender these days, but this is an incredibly tough Tennessee squad that’s no stranger to winning football games.


  • NY Giants are 0-6 ATS in their last six games.
  • Tennessee are 3-6 ATS in their last nine games.
  • The total has gone UNDER in nine of the Giants' last 11 games.
  • The total has gone UNDER in five of Tennessee's last six games.
  • NY Giants are 1-6 ATS in their last seven games against Tennessee.
  • The total has gone UNDER in five straight Titans' home games.
  • NY Giants are 0-5 ATS in their last five road games.
  • The Titans are 1-5 ATS in their last six games played in Week 1.

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