Tennessee Titans vs. Buffalo Bills Picks, Predictions, Odds

Week 2 of the NFL season will resume on Monday night with a heavyweight AFC bout between the Tennessee Titans and Buffalo Bills. Coverage begins from Highmark Stadium in Orchard Park at 7:15 p.m. ET on ESPN.


The Titans earned the top seed in the AFC with a record of 12-5 last year, and last week, they stormed out of the gate looking like a squad with similar intentions, as Tennessee jumped out to a commanding 13-0 lead in their Week 1 matchup against the Giants. However, Tennessee’s offense fell asleep at the wheel after that, as the Titans scored just seven points on 155 total yards in the second half against the G-Men, ultimately leading to an ugly 21-20 home loss.

The Bills, on the other hand, had a much tougher task to open the year, as Buffalo hit the road as narrow favorites over the Rams in Week 1, and made things look very easy against the reigning Super Bowl Champs, as the Bills erupted for 31 PTS on 413 total yards in a 21-point bloodbath to kick off the season last Thursday (W, 31-10).

Buffalo and Tennessee’s respective Week 1 matchups both stayed well under this number primarily due to excellent defense, as the Bills held L. A. to just 10 PTS on 243 total yards, while the Titans held N. Y. to 21 PTS on 395 total yards; and I expect to see that trend continue between two of the league’s top scoring defenses from last season, with the Bills averaging 18.3 PPG and the Titans averaging 20.7 PPG.

Score Prediction: Bills 26, Titans 17
Best Bet: Under 47.5 (-110)


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Date: Monday, Sept. 19, 2022
Matchup: AFC South vs. AFC East
Venue: Highmark Stadium
Location: Orchard Park, New York
Time-TV: ESPN, 7:15 p.m. ET


The Titans cruised to an AFC South title with a record of 12-5 last season, which paced the Colts (9-8), Texans (4-13), and Jaguars (3-14) by a distant margin; and tied the Chiefs for the top spot in the conference. However, Tennessee’s 27-3 victory over Kansas City in Week 7 ultimately served as the differentiating factor between the top two squads in the AFC last year.

Tennessee certainly hit a few roadblocks throughout the year, as Titans’ All-Pro RB Derrick Henry missed nearly half of the season due to a foot injury, who’s crucial to the Titans’ identity on the offensive side of the ball.

However, their defense stepped up enormously last season, as the Titans finished the year ranked 6th in points allowed and 11th in total yardage (20.7 PPG, 331 YPG), compared to their offense ranking 14th in scoring and 17th in total yardage (24.2 PPG, 343 YPG); which treads a thin line, as shown by their 21-20 loss to the Giants this past Sunday.

The Bills are 14-3 SU in their last 17 home games. (Getty Images)


Buffalo was pretty inconsistent to start last season, as the Bills posted a lackluster 7-6 record through the first 14 weeks of the year, however, Josh Allen and co. eventually caught fire and they cruised to an AFC East title with a 4-0 run to close out the regular season. For most of last season, Buffalo rode the coattail of its defense, as the Bills finished the year ranked first in both scoring and yardage allowed (18.3 DPPG, 289 YPG); but their offense flipped the script down the stretch and also wound up finishing third in scoring and fifth in total yardage (29.8 OPPG, 389 YPG), which nearly sprouted a Super Bowl caliber formula heading into the postseason.

The Bills also lit up the scoreboard in the playoffs, as the Buffalo’s offense tallied 41.5 OPPG on 452 YPG across a pair of postseason matchups against the Patriots and Chiefs. However, the Bills campaign came to an abrupt halt in the Divisional Round, as the Chiefs won the overtime coin toss and cashed in for six on the ensuing drive, stripping Buffalo’s red-hot offense of an opportunity to match in OT. So, the Bills sat on heartbreak all offseason, anxiously awaiting a chance to solidify themselves as a legitimate title threat, and a blowout road win over the defending champs in Week 1 ultimately did that, as Buffalo enters Week 2 favored by roughly 10 points over the Titans.


  • The Titans are 3-6 ATS in their last nine games.
  • The Bills are 4-1-1 ATS in their last six games.
  • The total has gone UNDER in five of Tennessee's last six games.
  • The total has gone OVER in five of Buffalo's last seven games.
  • The Titans are 6-3 ATS in their last nine games against Buffalo.
  • The Bills are 14-3 SU in their last 17 home games.
  • The Titans are 10-4 SU in their last 14 games against Buffalo.
  • The Bills are 8-4 SU in their last 12 home games against Tennessee.
  • The total has gone OVER in 12 of Tennessee's last 15 road games.

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