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Last Updated Sep 24, 2022, 7:20 PM

San Francisco 49ers vs. Denver Broncos Same Game Parlay Picks and Predictions

NFL betting expert Michael Crosson gives his same game parlay selection for Sunday night's primetime matchup between the San Francisco 49ers and Denver Broncos. Odds provided by DraftKings.

49ers vs. Broncos SGP Picks

  • Denver Broncos ML (+100)
  • Courtland Sutton (DEN) Over 4.5 Receptions (+105)
  • Brandon Aiyuk (SF) Over 49.5 Receiving Yards (-110)

Payout: +683

The Niners posted a rough start with QB Trey Lance under center, as San Francisco scored just 10 points on 331 total yards in a wild slip-and-slide game against Chicago in Week 1 (L, 19-10), which was followed by another relatively slow start against Seattle in Week 2, as they scored 21-of-27 points following Jimmy Garoppolo’s entry around the 2:30 mark in the first quarter.

The Broncos are also having an underwhelming start with a new signal-caller at the helm, considering Denver scored just 16 PPG on 392 YPG in their first two contests with Wilson, which was still good enough for a 1-1 split against the Texans and Seahawks, but doesn’t necessarily bode well heading into matchups against tougher opponents like the Niners.

I’ll back Denver here, as the Broncos have turned 783 total yards into just 32 points through the first two weeks of the season, however, I expect them to start cashing in more of those opportunities as Wilson continues to settle in with his new team, and I’m not sure if Garoppolo and co. will be able to match.

The Broncos’ receiving core has been surprisingly quiet to open the season, as Courtland Sutton appears to be first in the pecking order after seeing a team-high 18 targets through the first two weeks of the season, which is the same amount of combined targets Jerry Jeudy (10 TGT) and Albert Okwuegbunam (8 TGT) have seen thus far, who are next in line, aside from RB Javonte Williams (16 TGT).

I’ll back Sutton to have another solid night here, as Wilson heavily leaned on Sutton once things started looking gloomy for the Broncos last week, as he hauled in 7-of-11 targets for 122 yards in a 16-9 victory over Houston; and if Denver’s passing attack intends on flipping the script in the near future, I think it'll primarily come through the Wilson-Sutton connection.

Brandon Aiyuk flew under the radar in the Niners’ season-opener against Chicago, as the third year wideout hauled in two-of-three targets for 40 receiving yards in a 19-10 loss to the Bears in Week 1. Towards the end of Week 2, however, Garoppolo finally started to look his way more, as Aiyuk reeled in five-of-eight targets for 63 receiving yards in a 27-7 win over Seattle this past Sunday.

I’ll back Aiyuk to keep it going here, as he caught four or more passes in six of the Niners’ final eight contests last year, which includes a pair 65+ yard performances in the playoffs, and Aiyuk's usage will probably continue to increase with Garoppolo at the helm moving forward.

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