Last Updated Oct 09, 2022, 4:44 PM

Philadelphia Eagles vs. Arizona Cardinals Picks, Predictions, Odds

Week 5 of the NFL season will resume on Sunday mid-afternoon with a compelling NFC showdown between the Philadelphia Eagles and Arizona Cardinals. Coverage begins from State Farm Stadium in Glendale at 4:25 p.m. ET on FOX.


The Eagles stand as the lone undefeated team in the NFL heading into Week 5, as Philly’s offense racked up 28.8 PPG on 436 YPG across consecutive wins over Detroit, Minnesota, Washington, and Jacksonville to open the year; and while it’s fair to point out Philly hasn’t really played anybody yet, they can only beat the teams placed on their schedule, and they’ve certainly done that, highlighted by three of those victories coming by comfortable margins of 8+ PTS.

The Cardinals, on the other hand, have been incredibly inconsistent since drafting Kyler Murray with the first-overall pick of the 2019 draft, however, opening the season with matchups against the Chiefs, Raiders, Rams, and Panthers isn’t exactly a walk in the park either, so it’s tough to put much weight in Arizona’s defense surrendering 25.8 PPG on 343 YPG across their first four contests, especially after holding Carolina to just 16 PTS on 220 YDS in Week 4.

The Cardinals are a very dangerous squad, but their offense is currently riding a rollercoaster that I’m just not willing to climb aboard. I’ll back Philly here, as the Cardinals looked terrible in their first two home matchups of the year, as Murray and co. scored 21 PTS or less in both of Arizona’s home losses to the Chiefs and Rams (16.5 PPG), which doesn’t bode well heading into Sunday’s matchup against a red-hot Eagles’ offense that’s scored 24+ PTS in four straight contests (28.8 PPG).

Score Prediction: Eagles 28, Cardinals 20
Best Bet: Eagles -5.5 (-105)


More Odds | Super Bowl Odds | Expert Picks


Date: Sunday, Oct. 9, 2022
Matchup: NFC East vs. NFC West
Venue: SoFi Stadium
Location: Inglewood, California
Time-TV: FOX, 4:25 p.m. ET


The Eagles’ defense was relatively pedestrian in DC Jonathan Gannon’s first campaign with the team, as Philly’s defense finished last season ranked 19th in scoring 10th in total yardage (23.1 PPG, 330 YPG), which was good enough to keep them afloat in most contests, but not enough compete with top tier NFC squads like Tampa Bay and Los Angeles.

However, Philly’s defense has been phenomenal to start this season, as the Eagles surrendered just 17.8 PPG and forced 10 turnovers in four straight victories to open the year, which is the type of dominance capable of propelling this squad into Super Bowl contention, but we’ll see if they continue to churn out similar numbers in tougher matchups down the line.

The Eagles are 2-6 SU in their last eight matchups against Arizona. (Getty Images)


After barreling out to an impressive 10-2 start last season, the Cardinals completely fell apart down the homestretch, as Arizona wrapped up the regular season with a frustrating 1-4 SU skid, which included head-scratching losses to the Lions, Colts, and Seahawks. However, Arizona still managed to secure the top NFC Wild Card spot with a record of 11-6, but the Cardinals’ struggles only got worse in the playoffs, as the Rams stomped them by a score of 34-11 on Wild Card Weekend.

So, compared to last year’s miserable closing skid, the Cardinals have looked great to open this season, however, they still got manhandled by 8+ PTS in a pair of tough home matchups against Kansas City and L. A., and we’ll probably see a similar result against this red-hot Eagles squad in Week 5.


  • The Eagles are 8-2 SU in their last 10 games.
  • The Cardinals are 3-7 ATS in their last 10 games.
  • The Eagles are 1-6-1 ATS in their last eight games against Arizona.
  • The total has gone UNDER in six of Arizona's last nine games.
  • The Eagles are 2-6 SU in their last eight games against Arizona.
  • The Cardinals are 3-7 SU in their last 10 games.
  • The Eagles are 4-1 SU in their last five road games.
  • The total has gone UNDER in five of the last seven matchups between the Eagles and Cardinals.
  • The Eagles are 0-5 ATS in their last five road games against Arizona.
  • The Cardinals are 0-7 ATS in their last seven home games.
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