Last Updated Nov 13, 2022, 8:07 PM

Los Angeles Chargers vs. San Francisco 49ers Picks, Predictions, Odds

The tenth weekend of regular season NFL action will conclude on Sunday night with a West Coast showdown between the Los Angeles Chargers and San Francisco 49ers. Coverage begins from Levi’s Stadium in Santa Clara at 8:20 p.m. ET on NBC.

LOS ANGELES CHARGERS vs. SAN FRANCISCO 49ERS BETTING PREDICTION

The Chargers have become notorious for their inconsistency over the last few seasons, but San Francisco tends to fall under that same umbrella, as the Niners followed up last year’s impressive playoff run with an underwhelming 4-4 start to the season, which includes head-scratching losses to the Bears, Broncos, and Falcons.

The Chargers never make anything look easy, and they’re still dealing with an array of health issues. But putting those things aside, L. A. enters Sunday night’s matchup riding a solid 4-1 stretch, which includes wins over the Broncos and Falcons, both teams that San Francisco already lost to this season.

This matchup has ugly written all over it, and L. A. certainly knows how to win ugly football games. I very rarely trust Brandon Staley’s squad with my money these days, but as heavy underdogs against a .500 Niners team quarterbacked by Jimmy Garoppolo, it’s tough to resist taking a flier on the Bolts ML here.

Score Prediction: Chargers 23, 49ers 20
Best Bet: Chargers ML (+250)

LOS ANGELES CHARGERS vs. SAN FRANCISCO 49ERS BETTING ODDS

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LOS ANGELES CHARGERS vs. SAN FRANCISCO 49ERS BETTING RESOURCES

Date: Sunday, November 13, 2022
Matchup: AFC West vs. NFC West
Venue: Levi's Stadium
Location: Santa Clara, California
Time-TV: NBC, 8:20 p.m. ET

LOS ANGELES CHARGERS BETTING ANALYSIS

Typically, I avoid the Chargers like the plague. However, they are usually offered at a much different price point, as Sunday night’s matchup marks just the third time L. A. has been tagged as an underdog of 3.5+ PTS since the beginning of last season, and the two times that they were doubted on that level prior to this contest both came in road matchups against Kansas City.

It’s not exactly an ideal spot for the Chargers, as San Francisco’s defense appears to get better every week, and Justin Herbert has seen his fair share of struggles in the absence of his top two receivers Keenan Allen and Mike Williams.

However, the Chargers keep squeaking out victories, and somehow, they’ve now strung together wins in four of their last five games. And while the oddsmakers seem to think L. A.’s run will come to an abrupt halt on Sunday night, I’d rather take a flier on the Bolts as heavy underdogs to escape with another victory here. They don’t get offered at this price point often.

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The Chargers are 4-1 ATS in their last five matchups against San Francisco. (Getty)

LOS ANGELES CHARGERS BETTING ANALYSIS

The Niners stumbled out to a slow start with Trey Lance under center, as San Francisco scored just 10 points on 331 total yards in a wild slip-and-slide game against Chicago in Week 1 (L, 19-10), which was followed by another weak performance out of the gate against Seattle in Week 2, as 21 of the Niners’ 27 points came after Garoppolo’s entry in the first half.

The Niners defense absolutely dominated in their first five weeks of the season, as San Francisco allowed just 12.2 PPG on 249 YPG across an impressive 3-2 start. However, they’ve appeared a bit vulnerable since that stretch, highlighted by the Niners entering Sunday having surrendered 28+ PTS in two of their last three contests (28.7 PPG), making it very difficult for Garoppolo and co. to keep up.

LOS ANGELES CHARGERS vs. SAN FRANCISCO 49ERS BETTING TRENDS

  • The total has gone OVER in 10 of the Chargers' last 14 games.
  • The Chargers are 4-1 SU in their last five games.
  • The Niners are 14-6 ATS in their last 20 games.
  • The total has gone UNDER in 12 of San Francisco's last 16 games.
  • The Niners are 13-7 SU in their last 20 games.
  • The total has gone OVER in eight of San Francisco's last 11 games against the Chargers.
  • The Niners are 6-1 ATS in their last seven home games.
  • The Chargers are 4-1 ATS in their last five games against San Francisco.
  • The Chargers are 5-0 SU in their last five games against San Francisco.
  • The Chargers are 4-1 ATS in their last five road games.
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