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Last Updated Aug 30, 2021, 9:45 AM

2021 NFL Schedule Release, Betting Odds

Week 1 NFL Betting Line Movements

Buccaneers open season vs. Cowboys

The 2021 NFL Regular Season was released on Thursday May 12 and the opening weekend is currently scheduled to begin in Week 1 on Thursday Sept. 9, 2021 and run through Week 18 which finishes on Sunday, Jan. 9, 2022.

A total of 272 games are scheduled to be played among the 32 teams before the NFL Playoffs begin. The NFL postseason will end on Sunday February, 13, 2022 with Super Bowl LVI at SoFI Stadium from Los Angeles, California.

2021 NFL Week 1 Betting Odds

Bettors looking for early NFL Betting Markets should look no further than the Westgate SuperBook .

All of the NFL Week 1 Betting Odds for the regular season are listed below from Westgate SuperBook.

NFL Week 1 Schedule & Betting Odds
Thursday, September, 9, 2021
Time (ET) Away Home
8:20 p.m. ET Dallas Tampa Bay (-6.5, 52)
Sunday, September 12, 2021
Time (ET) Away Home
1:00 p.m. ET Pittsburgh Buffalo (-6, 49.5)
1:00 p.m. ET N.Y. Jets Carolina (-4.5, 43)
1:00 p.m. ET Jacksonville (-3, 45.5) Houston
1:00 p.m. ET Arizona Tennessee (-2.5, 51)
1:00 p.m. ET L.A. Chargers (-1.5, 44.5) Washington
1:00 p.m. ET Philadelphia Atlanta (-3.5, 47)
1:00 p.m. ET Seattle Indianapolis (-3, 52)
1:00 p.m. ET Minnesota (-3, 48) Cincinnati
1:00 p.m. ET San Francisco (-7, 45.5) Detroit
4:25 p.m. ET Cleveland Kansas City (-6.5, 53)
4:25 p.m. ET Miami New England (-2.5, 44.5)
4:25 p.m. ET Denver (-1, 42) N.Y. Giants
4:25 p.m. ET Green Bay New Orleans (-3, 50.5)
8:25 p.m. ET Chicago L.A. Rams (-7, 44.5)
Monday, September 13, 2021
Time (ET) Away Home
8:00 p.m. ET Baltimore (-3.5, 51) Las Vegas

*Odds subject to change

Schedule Breakdown

Brady and Bucs raise banner

Last season closed out at Raymond James Stadium with Tom Brady and the Tampa Bay Buccaneers routing the Kansas City Chiefs to capture its second Super Bowl title in franchise history.

Brady leads Tampa Bay in the season opener on Thursday September 9 against the Dallas Cowboys at home. The last time Brady opened the season on Thursday Night Football, the Patriots were blown out by the Chiefs, 42-27 as eight-point favorites in 2017.

Tom Brady and the Buccaneers open up their title defense in Week 1 against the Dallas Cowboys. (AP)

Division Showdowns

Only one game in Week 1 involves a pair of divisional rivals, which takes place in Houston between the Jaguars and Texans.

Jacksonville opened as a 3-point road favorite in the much-anticipated debut of top pick Trevor Lawrence. Houston is still undecided at the quarterback position with Deshaun Watson's status in the air currently.

Old Faces in New Places

Matthew Stafford will make his first start as a member of the Los Angeles Rams on the Sunday Night Football stage when the Chicago Bears invade SoFi Stadium.

The Rams defeated the Bears on Monday Night Football last season, 24-10, as L.A. is a seven-point favorite here, marking their second straight appearance in the Sunday Night Football opener of the season.

Meanwhile, Jared Goff starts his tenure as quarterback of the Detroit Lions against the San Francisco 49ers at Ford Field as 7.5-point home underdogs.

The schedule makers didn't post a Jets-Panthers matchup by accident in Week 1 as Sam Darnold will square off against his former team in Charlotte. Carolina is a five-point favorite in Darnold's first outing against the team that drafted him in 2018.

Lights On in Sin City

Only one Monday Night Football game takes place in Week 1 this season as opposed to the traditional doubleheader with the Las Vegas Raiders hosting the Baltimore Ravens at Allegiant Stadium.

The Raiders missed the playoffs in their first season in Las Vegas, but the Silver and Black dominated New Orleans as a home underdog in their first primetime game in 2020. This time around, the Ravens are 3.5-point favorites against the Raiders.

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