CBB: Santa Clara vs. Xavier: Prediction, Odds, Best Bet

Derek Mountain Sports Betting Expert

7 minute read

_{Image Credit: Kyle Terada via Imagn Images}

The Santa Clara Broncos (2-0) and Xavier Musketeers (2-0) will face off in College Basketball tonight. Tipoff is set for 8:30 p.m. EST from Cintas Center in Cincinnati, Ohio. The game will broadcast live on Fox Sports 1.

The Xavier Musketeers are favored by -3.5 on the spread, with the over/under set at 155.5 total points. The Musketeers are -192 favorites to win outright on the moneyline, while the Broncos are +160 to pull off the upset.

Be sure to check out the latest NCAAB odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 11/10/25

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Santa Clara Broncos vs. Xavier Musketeers Best Bet

I'll take plus money with Santa Clara ML. Even on the road, I view this game as a pick' em, so I'm rolling with the ML.

From a pure talent standpoint, I'd take Santa Clara. Plus, it's still early in the season, and I value teams that have experience playing together. Santa Clara has four starters who were with the program last year — and Xavier has none.

I think Xavier will be among the worst high-major teams in the country — and the Broncos, while they are a WCC team, operate like a high-major program. They have plenty of talent and a proven style that leads to winning.

Santa Clara vs. Xavier Best Bet: Santa Clara ML

(Pick from Sean Paul)

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Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain