South Dakota State vs Iowa State Prediction, Picks, Odds | NCAA Tournament First Round Bets

The First Round of NCAA Men's Basketball Tournament kicks off on Thursday, March 21 -- and the 12th matchup on the slate set to tip off is South Dakota State vs Iowa State, which is scheduled for 7:35 p.m. ET on truTV.
The Cyclones have climbed to 16.5-point favorites on the spread for Thursday's contest after originally opening at -14.5; with the game total stationed around over/under 135 at most sportsbooks.
Here's everything you need to know about South Dakota State vs Iowa State -- our expert prediction and betting picks for this First Round NCAA Tournament matchup.
South Dakota State vs Iowa State Odds
SDKST @ IAST Odds
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+14.5 -102 | +15.5 -110 | +15.5 -115 | +15 -110 | +15.5 -115 | +15.5 -114 | +16 -113 | +15.5 -120 | +15.5 -114 | ||
![]() | -14.5 -120 | -15.5 -110 | -15.5 -105 | -15 -110 | -15.5 -105 | -15.5 -106 | -16 -107 | -15.5 -110 | -15.5 -106 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
o134.5 -110 | o135.5 -110 | o134.5 -115 | o135 -110 | o135.5 -110 | o135.5 -104 | o135 -110 | o135.5 -115 | o135.5 -104 | ||
![]() | u134.5 -110 | u135.5 -110 | u134.5 -105 | u135 -110 | u135.5 -110 | u135.5 -118 | u135 -110 | u135.5 -115 | u135.5 -118 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+1160 | +800 | +950 | +850 | +850 | +980 | +1050 | +700 | +980 | ||
![]() | -2800 | -1300 | -2000 | -1450 | -1500 | -2000 | -2500 | -2000 | -2000 | |
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+14.5 -102 | +8.5 -110 | +8.5 -115 | +9 -115 | +8.5 -115 | N/A | +9.5 -117 | +8.5 -115 | +15.5 -114 | ||
![]() | -14.5 -120 | -8.5 -110 | -8.5 -115 | -9 -115 | -8.5 -115 | N/A | -9.5 -109 | -8.5 -115 | -15.5 -106 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
o134.5 -110 | o63.5 -105 | N/A | o63 -120 | o63.5 -110 | o63.5 -106 | o64.5 -112 | o63.5 -110 | o135.5 -104 | ||
![]() | u134.5 -110 | u63.5 -115 | N/A | u63 -110 | u63.5 -120 | u63.5 -118 | u64.5 -114 | u63.5 -120 | u135.5 -118 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+1160 | N/A | +500 | +420 | +400 | N/A | +600 | N/A | +980 | ||
![]() | -2800 | N/A | -900 | -660 | -700 | N/A | -910 | N/A | -2000 | |
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+14.5 -102 | +7 -110 | N/A | N/A | N/A | +7.5 -112 | +7.5 -117 | N/A | +15.5 -114 | ||
![]() | -14.5 -120 | -7 -110 | N/A | N/A | N/A | -7.5 -112 | -7.5 -109 | N/A | -15.5 -106 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
o134.5 -110 | o72 -110 | N/A | N/A | N/A | o71.5 -112 | N/A | N/A | o135.5 -104 | ||
![]() | u134.5 -110 | u72 -110 | N/A | N/A | N/A | u71.5 -112 | N/A | N/A | u135.5 -118 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
+1160 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | +980 | ||
![]() | -2800 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | -2000 | |
South Dakota State vs Iowa State Prediction
Iowa State turned plenty of heads in the Big 12 championship by routing top-seed Houston, 69-41 as 5.5-point underdogs.
The Cyclones are the 2nd seed in the East region, but don't get much of a home-court advantage in Omaha as they face Summit League champion South Dakota State.
Iowa State owned the best defense efficiency ranking in the country, while holding Kansas State, Baylor, and Houston to 62 points or fewer in the Big 12 tournament.
The Jackrabbits will fire away as they rank 50th in the country in 3-point shooting at 36.2%, as South Dakota State is listed in its highest underdog spot of the season.
The expectations are high for Iowa State off the Big 12 tournament title as this is only the second time the Cyclones are a favorite in the Big Dance since 2021.
Pick: South Dakota State +16.5 (-110)
South Dakota State vs Iowa State Game Time & TV Channel
Date: Thursday, March 21
Matchup: Summit vs Big 12
Venue: CHI Health Center Omaha
Location: Omaha, Nebraska
Time-TV: truTV, 7:35 p.m. ET
South Dakota State vs Iowa State Betting Stats
2) Iowa State Cyclones
(Big 12, Automatic)
- Futures: +1900
- Region: +550
- SU: 27-7
- ATS: 22-10-2
- O/U: 16-18
- PPG: 75.7
- OPPG: 62.1
15) South Dakota State Jackrabbits
(Summit, Automatic)
- Futures: +40000
- Region: +15000
- SU: 22-12
- ATS: 17-14
- O/U: 15-15-1
- PPG: 77.3
- OPPG: 71.9
March Madness Betting Resources
- NCAA Tourney Picks
- NCAAB Matchups
- NCAAB Scores
- NCAAB Teams
- NCAAB Free Picks
- NCAAB Premium Picks
- NCAAB Consensus Picks
- NCAAB Parlay Picks
- March Madness History
March Madness First Round Odds
The NCAA Men's Tournament First Round will take place on Thursday March 21, 2024 and Friday March 22, 2024.
Check out the Teams, Odds, Betting Stats and much more on each of the four regions below:
College Basketball News
- COLLEGE-BASKETBALL APR 6, 2025
Free NCAAB Picks & Predictions By Vegas Insider
- COLLEGE-BASKETBALL APR 6, 2025
2025 NCAA Men’s Basketball National Championship Odds
- COLLEGE-BASKETBALL MAR 12, 2025
2025 WCC Tournament Odds: Gonzaga Favored vs. St. Mary’s In Final
- COLLEGE-BASKETBALL MAR 19, 2025
NCAAB: Xavier vs. Texas NCAA Tournament First Four Pick & Prediction
- COLLEGE-BASKETBALL APR 6, 2025
Final Four Odds: 2025 March Madness Lines, Spreads, Betting Trends
- COLLEGE-BASKETBALL APR 7, 2025
Florida vs. Houston Odds, Lines, Betting Trends & Predictions For NCAA Championship Game
Featured News
- FEATURED JUN 14, 2025
NBA Playoff Odds: NBA Finals Lines, Spreads, Betting Trends
- FEATURED JUN 14, 2025
2025 U.S. Open Odds: Burns Surprise Favorite Entering Moving Day
- FEATURED JUN 13, 2025
Illinois Sports Betting Tax: ‘Another Set of Teeth on the Buzzsaw’
- FEATURED JUN 14, 2025
2025 College World Series Odds: Arkansas Favorite, LSU Close Behind
- FEATURED JUN 13, 2025
Al Ahly vs Inter Miami Predictions, Odds and Betting Tips
- FEATURED JUN 13, 2025
Bayern Munich vs Auckland City Predictions, Odds and Betting Tips