Eastern Kentucky Colonels Odds
| Date | Opp | Close | Result | ATS/OU |
| Aug 30, 2025 | @Louisville | -
/ | | 3:00 PM ET |
| Sep 6, 2025 | Houston Christian | -
/ | | 12:00 PM ET |
| Sep 13, 2025 | @Marshall | -
/ | | 6:00 PM ET |
| Sep 20, 2025 | @West Georgia | -
/ | | 6:00 PM ET |
| Sep 27, 2025 | Nicholls State | -
/ | | 12:00 PM ET |
| Oct 11, 2025 | Austin Peay | -
/ | | 12:00 PM ET |
| Oct 18, 2025 | @North Alabama | -
/ | | 12:00 PM ET |
| Oct 25, 2025 | Tarleton State | -
/ | | 12:00 PM ET |
| Nov 1, 2025 | @Central Arkansas | -
/ | | 5:00 PM ET |
| Nov 8, 2025 | Southern Utah | -
/ | | 1:00 PM ET |
| Nov 15, 2025 | Abilene Christian | -
/ | | 1:00 PM ET |
| Nov 22, 2025 | @Utah Tech | -
/ | | 1:00 PM ET |
• 
Eastern Kentucky 0 - 0 
Louisville 0 - 0