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Featured Last Updated Oct 17 2025, 9:43 AM

NFL: Atlanta Falcons vs. San Francisco 49ers: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Atlanta Falcons vs. San Francisco 49ers: Prediction, Odds, Best Bet

Featured Image Credit: Brett Davis-Imagn Images

ATL @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Atlanta Falcons 473 Falcons
+6.5 -110 +0.5 -125 + +0.5 -125 + +0.5 -130 + -1.5 +110 + +0.5 -125 + -1.5 +120 + +0.5 -125 + -0.5 +115 +1.5 -143 + +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 -0.5 +105 + -0.5 +105 + -0.5 +110 + +1.5 -139 + -0.5 -105 + +1.5 -140 + -0.5 +105 + +0.5 -140 -1.5 +115 + -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o23.5 -105 + N/A o23.5 -102 + o23.5 -107 + N/A o23.5 -115 + o23.5 -105 + o22.5 -135 o23.5 -110 + o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u23.5 -115 + N/A u23.5 -118 + u23.5 -112 + N/A u23.5 -105 + u23.5 -115 + u22.5 +110 u23.5 -113 + u47.5 -120  
Atlanta Falcons 473 Falcons
+225 -105 + -105 + -108 + -108 + even + -110 + N/A -105 -106 + +114  
San Francisco 49ers 474 49ers
-278 -115 + -115 + -112 + -114 + -130 + -110 + N/A -115 -117 + -135  
Atlanta Falcons 473 Falcons
+6.5 -110 +0.5 -155 + +0.5 -185 + +0.5 -170 + N/A +0.5 -160 + -1.5 +144 + +0.5 -170 + +1.5 -185 -2.5 +143 + +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 -0.5 +130 + -0.5 +140 + -0.5 +142 + N/A -0.5 +125 + +1.5 -170 + -0.5 +140 + -1.5 +135 +2.5 -180 + -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o7.5 -110 + N/A o7.5 -108 + N/A o9.5 -110 + o8.5 -112 + o8.5 -110 + o8.5 -120 o8.5 -114 + o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u7.5 -110 + N/A u7.5 -112 + N/A u9.5 -120 + u8.5 -108 + u8.5 -110 + u8.5 -110 u8.5 -109 + u47.5 -120  
Atlanta Falcons 473 Falcons
+225 -110 + -110 + -110 + N/A even + -115 + N/A -110 -120 + +114  
San Francisco 49ers 474 49ers
-278 -110 + -110 + -110 + N/A -130 + -104 + N/A -120 -105 + -135  
Atlanta Falcons 473 Falcons
+6.5 -110 +0.5 -115 + N/A +1.5 -122 + N/A N/A +1.5 -125 + N/A N/A +1.5 -132 + +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 -0.5 -105 + N/A -1.5 +102 + N/A N/A -1.5 +105 + N/A N/A -1.5 +106 + -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o23.5 -110 + N/A o23.5 -102 + N/A N/A o23.5 -100 + o23.5 -115 + N/A o23.5 -107 + o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u23.5 -110 + N/A u23.5 -118 + N/A N/A u23.5 -120 + u23.5 -115 + N/A u23.5 -117 + u47.5 -120  
Atlanta Falcons 473 Falcons
+225 -105 + N/A +110 + N/A N/A +114 + N/A N/A +104 + +114  
San Francisco 49ers 474 49ers
-278 -115 + N/A -130 + N/A N/A -130 + N/A N/A -129 + -135  
Atlanta Falcons 473 Falcons
+6.5 -110 N/A N/A +0.5 -135 + N/A N/A +1.5 -148 + +0.5 -140 + N/A N/A +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 N/A N/A -0.5 +114 + N/A N/A -1.5 +122 + -0.5 +110 + N/A N/A -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o13.5 -110 + N/A o14.5 +102 + N/A N/A o13.5 -128 + o13.5 -130 + N/A N/A o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u13.5 -110 + N/A u14.5 -122 + N/A N/A u13.5 -124 + u13.5 even + N/A N/A u47.5 -120  
Atlanta Falcons 473 Falcons
+225 even + N/A -110 + N/A N/A -104 + N/A N/A N/A +114  
San Francisco 49ers 474 49ers
-278 -120 + N/A -110 + N/A N/A -118 + N/A N/A N/A -135  
Atlanta Falcons 473 Falcons
+6.5 -110 N/A N/A +0.5 -142 + N/A N/A +1.5 -152 + +0.5 -140 + N/A N/A +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 N/A N/A -0.5 +120 + N/A N/A -1.5 +122 + -0.5 +110 + N/A N/A -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o10 -105 + N/A o9.5 -122 + N/A N/A o9.5 -126 + o9.5 -130 + N/A N/A o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u10 -115 + N/A u9.5 even + N/A N/A u9.5 +104 + u9.5 even + N/A N/A u47.5 -120  
Atlanta Falcons 473 Falcons
+225 -105 + N/A +105 + N/A N/A +116 + N/A N/A N/A +114  
San Francisco 49ers 474 49ers
-278 -115 + N/A -125 + N/A N/A -140 + N/A N/A N/A -135  
Atlanta Falcons 473 Falcons
+6.5 -110 +0.5 -140 + N/A +0.5 -122 + N/A N/A +1.5 -166 + +1.5 -150 + N/A N/A +1.5 -105  
San Francisco 49ers 474 49ers
-6.5 -110 -0.5 +120 + N/A -0.5 +102 + N/A N/A -1.5 +136 + -1.5 +115 + N/A N/A -1.5 -115  
Atlanta Falcons 473 Falcons
o47.5 -105 o13.5 -110 + N/A o13.5 +102 + N/A N/A o13.5 +102 + o13.5 -110 + N/A N/A o47.5 even  
San Francisco 49ers 474 49ers
u47.5 -115 u13.5 -110 + N/A u13.5 -122 + N/A N/A u13.5 -128 + u13.5 -120 + N/A N/A u47.5 -120  
Atlanta Falcons 473 Falcons
+225 -110 + N/A +110 + N/A N/A -104 + N/A N/A N/A +114  
San Francisco 49ers 474 49ers
-278 -110 + N/A -130 + N/A N/A -114 + N/A N/A N/A -135  

The Falcons will take on the 49ers in this week's NFL action. Kickoff is set for 8:20 p.m. EDT at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on NBC. Here's everything you need to know about Falcons vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -1.5 point favorite over Falcons. The total is set at over/under 47 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Check out my full list of NFL Week 7 best bets.

Updated on 10/18/25

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Atlanta Falcons vs. San Francisco 49ers Best Bet

Brock Purdy or Mac Jones? I am not sure it matters. It finally looks like the Atlanta Falcons' defense has figured it out coming out of the bye. They showed us what the young defense is capable of on Monday Night Football against Buffalo. The Falcons are a bit more battle-tested than the 49ers, as they have the 5th-ranked strength of schedule compared to the 49ers ranking 21st.

The Falcons' offensive line has done a wonderful job at protecting Michael Penix Jr., and I expect the Falcons to keep this game close, at a minimum.

Atlanta Falcons vs. San Francisco 49ers Best Bet: Atlanta Falcons +2.5 (-112)

(Pick from Dylan Wilkerson)


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What Time is the Atlanta Falcons vs. San Francisco 49ers Game?

The Atlanta Falcons vs. San Francisco 49ers game is at 8:20 PM ET on Sunday, October 19th.

Where is the Atlanta Falcons vs. San Francisco 49ers Game Being Played?

This game will be played at Levi's Stadium in Santa Clara, Calif.

How Can I Watch Atlanta Falcons vs. San Francisco 49ers?

You can watch Atlanta Falcons vs. San Francisco 49ers on NBC.

Can the Falcons Beat the 49ers?

Of course! The Falcons are only a 1.5 point underdog so anyone can win.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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