Sign Up Subscribe
Featured Last Updated Sep 12 2025, 10:58 AM

NFL: 49ers vs. Saints, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: 49ers vs. Saints, Prediction, Odds, Best Bet

Featured Image Credit: Joe Nicholson via Imagn Images

SF @ NO Odds

  • Full Game
  • 1Q
  • 1H
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 267 49ers
-7 -105 -0.5 +125 + -0.5 +110 + -0.5 +120 + -0.5 +120 + -0.5 +115 + -1.5 +132 + -0.5 +110 -1.5 +128 + -1.5 +128 -3 -115  
New Orleans Saints 268 Saints
+7 -115 +0.5 -150 + +0.5 -140 + +0.5 -142 + +0.5 -150 + +0.5 -145 + +1.5 -162 + +0.5 -145 +1.5 -159 + +1.5 -159 +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o7.5 +115 + N/A o7.5 +110 + o7.5 +110 + o8.5 +105 + o7.5 +124 + o8.5 -110 o7.5 even + o7.5 even o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u7.5 -135 + N/A u7.5 -130 + u7.5 -140 + u8.5 -135 + u7.5 -150 + u8.5 -120 u7.5 -129 + u7.5 -129 u40.5 -108  
San Francisco 49ers 267 49ers
-340 -135 + N/A -142 + -145 + -140 + -134 + -145 -137 + -137 -170  
New Orleans Saints 268 Saints
+270 +115 + N/A +120 + +115 + +110 + +110 + +110 +112 + +112 +145  
San Francisco 49ers 267 49ers
-7 -105 -1.5 -110 + N/A -2.5 -108 + -1.5 -110 + -2.5 -120 + -1.5 -105 + -2.5 even -1.5 -107 + -1.5 -107 -3 -115  
New Orleans Saints 268 Saints
+7 -115 +1.5 -110 + N/A +2.5 -112 + +1.5 -110 + +2.5 -110 + +1.5 -115 + +2.5 -120 +1.5 -115 + +1.5 -115 +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o20.5 -110 + N/A o20.5 -102 + o20.5 -105 + N/A o20.5 -100 + o20.5 -110 o20.5 -105 + o20.5 -105 o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u20.5 -110 + N/A u20.5 -118 + u20.5 -115 + N/A u20.5 -120 + u20.5 -110 u20.5 -118 + u20.5 -118 u40.5 -108  
San Francisco 49ers 267 49ers
-340 -150 + N/A -155 + -155 + -160 + -144 + -145 -148 + -148 -170  
New Orleans Saints 268 Saints
+270 +125 + N/A +130 + +130 + +125 + +118 + +120 +118 + +118 +145  
San Francisco 49ers 267 49ers
-7 -105 -1.5 -105 + N/A -1.5 -108 + -0.5 -115 + N/A -1.5 -100 + N/A -1.5 -107 + -1.5 -107 -3 -115  
New Orleans Saints 268 Saints
+7 -115 +1.5 -115 + N/A +1.5 -112 + +0.5 -105 + N/A +1.5 -120 + N/A +1.5 -117 + +1.5 -117 +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o19.5 -110 + N/A o19.5 -115 + o19.5 -115 + N/A o19.5 -120 + N/A o19.5 -120 + o19.5 -120 o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u19.5 -110 + N/A u19.5 -105 + u19.5 -105 + N/A u19.5 -100 + N/A u19.5 -105 + u19.5 -105 u40.5 -108  
San Francisco 49ers 267 49ers
-340 -135 + N/A -142 + N/A N/A -142 + N/A -148 + -148 -170  
New Orleans Saints 268 Saints
+270 +115 + N/A +120 + N/A N/A +120 + N/A +118 + +118 +145  
San Francisco 49ers 267 49ers
-7 -105 N/A N/A -0.5 -110 + -1.5 +110 + N/A -1.5 +108 + N/A N/A N/A -3 -115  
New Orleans Saints 268 Saints
+7 -115 N/A N/A +0.5 -110 + +1.5 -130 + N/A +1.5 -132 + N/A N/A N/A +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o12.5 -135 + N/A o12.5 -130 + o12.5 -130 + N/A o12.5 -132 + N/A N/A N/A o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u12.5 +115 + N/A u12.5 +110 + u12.5 +110 + N/A u12.5 +108 + N/A N/A N/A u40.5 -108  
San Francisco 49ers 267 49ers
-340 -150 + N/A -148 + -135 + N/A -140 + N/A N/A N/A -170  
New Orleans Saints 268 Saints
+270 +125 + N/A +124 + +115 + N/A +114 + N/A N/A N/A +145  
San Francisco 49ers 267 49ers
-7 -105 N/A N/A -0.5 +114 + -1.5 +125 + N/A -1.5 +126 + N/A N/A N/A -3 -115  
New Orleans Saints 268 Saints
+7 -115 N/A N/A +0.5 -135 + +1.5 -145 + N/A +1.5 -154 + N/A N/A N/A +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o7.5 +105 + N/A o7.5 even + o7.5 +105 + N/A o7.5 +104 + N/A N/A N/A o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u7.5 -125 + N/A u7.5 -120 + u7.5 -125 + N/A u7.5 -128 + N/A N/A N/A u40.5 -108  
San Francisco 49ers 267 49ers
-340 -135 + N/A -135 + -135 + N/A -138 + N/A N/A N/A -170  
New Orleans Saints 268 Saints
+270 +115 + N/A +114 + +115 + N/A +112 + N/A N/A N/A +145  
San Francisco 49ers 267 49ers
-7 -105 -0.5 +105 + N/A -0.5 +102 + -1.5 +120 + N/A -1.5 +118 + N/A N/A N/A -3 -115  
New Orleans Saints 268 Saints
+7 -115 +0.5 -125 + N/A +0.5 -122 + +1.5 -140 + N/A +1.5 -144 + N/A N/A N/A +3 -105  
San Francisco 49ers 267 49ers
o44.5 -110 o10.5 +105 + N/A o10.5 -102 + o10.5 -105 + N/A o10.5 -100 + N/A N/A N/A o40.5 -112  
New Orleans Saints 268 Saints
u44.5 -110 u10.5 -125 + N/A u10.5 -118 + u10.5 -115 + N/A u10.5 -122 + N/A N/A N/A u40.5 -108  
San Francisco 49ers 267 49ers
-340 -130 + N/A -135 + -150 + N/A -134 + N/A N/A N/A -170  
New Orleans Saints 268 Saints
+270 +110 + N/A +114 + +120 + N/A +110 + N/A N/A N/A +145  

The 49ers will take on the Saints in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Caesars Superdome in New Orleans, La. The game will be broadcast live on FOX. Here's everything you need to know about 49ers vs. Saints odds, the latest NFL spreads, NFL over/unders and more.

The 49ers opened as a -3 point favorite over Saints. The total is set at over/under 40.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/12/25

bet365
Bet $5, Get $300 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $300
New customers only, 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $300 in Bonus Bets at bet365. Registration required. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply.

San Francisco 49ers vs. New Orleans Saints Best Bet

The 49ers had the seventh-best Week 1 through the air with 0.35 expected points added per dropback, and while their newly-fortified backfield with Brian Robinson Jr. failed to make a mark, they’ll draw one of the least-talented rush defenses in the league as the Saints allowed Arizona to average 5.4 yards on 27 carries.

The Cardinals totally took the game out of the Saints’ hands with an early barrage on the ground, and while the passing game ultimately held them back, we are looking at a sturdy two-pronged attack on the Niners’ side.

I’m still not entirely sure what we get out of this defense, which lost Nick Bosa among others in the offseason, but at least in this game – against Spencer Rattler – it shouldn’t matter.

49ers vs. Saints Best Bet: 49ers -3

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the New Orleans Saints vs. San Francisco 49ers Game?

The New Orleans Saints will take on the San Francisco 49ers at 1:00 ET on Sunday, September 14th.

Where is the New Orleans Saints vs. San Francisco 49ers Game Being Played?

This game is going to be played at the Caesars Superdome in New Orleans, Louisiana.

How Can I Watch 49ers vs. Saints?

You can watch 49ers vs Saints on FOX.

Can the Saints Beat the 49ers?

The 49ers will be without star tight end George Kittle and quarterback Brock Purdy - without those two, the Saints can make this a highly-contested game.

Featured News

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
•