Sign Up Subscribe
Featured Last Updated Oct 8 2026, 1:28 PM

49ers vs. Seahawks Predictions: 49ers Luck Turns South

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
49ers vs. Seahawks Predictions: 49ers Luck Turns South

The San Francisco 49ers will take on the Seattle Seahawks in this week's NFL action. Kickoff is set for 4:25 PM EST at LUmen Field in Seattle, WA. The game will be broadcast live on FOX. Here's everything you need to know about 49ers vs. Seahawks odds, the latest college football spreads, college football over/unders and more.

SF @ SEA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 469 49ers
+3.5 -110 +2.5 -105 + +2.5 -108 + +1.5 -112 + +2.5 -109 + +2.5 -110 + +2.5 -115 + +1.5 even + +1.5 -110 + +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 -2.5 -115 + -2.5 -110 + -1.5 -108 + -2.5 -110 + -2.5 -110 + -2.5 -115 + -1.5 -120 + -1.5 -112 + -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o22.5 -125 + o23.5 even + o22.5 -125 + o22.5 -127 + o23.5 +105 + o22.5 -130 + o22.5 -135 + o22.5 -130 + o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u22.5 +105 + u23.5 -130 + u22.5 +105 + u22.5 +106 + u23.5 -125 + u22.5 even + u22.5 even + u22.5 +104 + u45.5 -105  
San Francisco 49ers 469 49ers
+170 +125 + +135 + +124 + +126 + +130 + N/A +130 + +116 + +136  
Seattle Seahawks 470 Seahawks
-205 -150 + -160 + -148 + -152 + -160 + N/A -155 + -141 + -162  
San Francisco 49ers 469 49ers
+3.5 -110 +0.5 -135 + +0.5 -145 + +0.5 -142 + N/A +1.5 -146 + +0.5 -140 + +0.5 -140 + +1.5 -152 + +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 -0.5 +115 + -0.5 +110 + -0.5 +120 + N/A -1.5 +120 + -0.5 +110 + -0.5 +115 + -1.5 +123 + -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o9.5 -105 + o9.5 -110 + o9.5 -108 + N/A o9.5 -108 + o8.5 -115 + o9.5 -115 + o9.5 -105 + o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u9.5 -115 + u9.5 -115 + u9.5 -112 + N/A u9.5 -112 + u8.5 -115 + u9.5 -115 + u9.5 -120 + u45.5 -105  
San Francisco 49ers 469 49ers
+170 +120 + +120 + +114 + N/A +118 + N/A +120 + +108 + +136  
Seattle Seahawks 470 Seahawks
-205 -140 + -150 + -135 + N/A -144 + N/A -160 + -132 + -162  
San Francisco 49ers 469 49ers
+3.5 -110 +1.5 -115 + N/A +1.5 -125 + N/A +1.5 -120 + +0.5 -110 + N/A +1.5 -120 + +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 -1.5 -105 + N/A -1.5 -105 + N/A -1.5 -100 + -0.5 -120 + N/A -1.5 -104 + -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o22.5 -120 + N/A o22.5 -115 + N/A o22.5 -115 + o22.5 -120 + N/A o22.5 -122 + o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u22.5 even + N/A u22.5 -105 + N/A u22.5 -105 + u22.5 -110 + N/A u22.5 even + u45.5 -105  
San Francisco 49ers 469 49ers
+170 +120 + N/A +110 + N/A +120 + N/A N/A +114 + +136  
Seattle Seahawks 470 Seahawks
-205 -140 + N/A -140 + N/A -142 + N/A N/A -141 + -162  
San Francisco 49ers 469 49ers
+3.5 -110 N/A N/A +0.5 -125 + N/A +1.5 -124 + +0.5 -120 + N/A N/A +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 N/A N/A -0.5 -105 + N/A -1.5 +102 + -0.5 -110 + N/A N/A -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o13.5 -115 + N/A o13.5 -110 + N/A o13.5 -110 + o13.5 -115 + N/A N/A o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u13.5 -115 + N/A u13.5 -120 + N/A u13.5 -110 + u13.5 -115 + N/A N/A u45.5 -105  
San Francisco 49ers 469 49ers
+170 +120 + N/A +110 + N/A +122 + N/A N/A N/A +136  
Seattle Seahawks 470 Seahawks
-205 -150 + N/A -140 + N/A -150 + N/A N/A N/A -162  
San Francisco 49ers 469 49ers
+3.5 -110 N/A N/A +0.5 -145 + N/A +1.5 -152 + +0.5 -150 + N/A N/A +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 N/A N/A -0.5 +114 + N/A -1.5 +124 + -0.5 +115 + N/A N/A -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o9.5 -120 + N/A o9.5 -120 + N/A o9.5 -110 + o9.5 -115 + N/A N/A o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u9.5 -110 + N/A u9.5 -110 + N/A u9.5 -110 + u9.5 -115 + N/A N/A u45.5 -105  
San Francisco 49ers 469 49ers
+170 +105 + N/A even + N/A +114 + N/A N/A N/A +136  
Seattle Seahawks 470 Seahawks
-205 -135 + N/A -130 + N/A -140 + N/A N/A N/A -162  
San Francisco 49ers 469 49ers
+3.5 -110 +1.5 -150 + N/A +0.5 -125 + N/A +1.5 -146 + +0.5 -130 + N/A N/A +3 -110  
Seattle Seahawks 470 Seahawks
-3.5 -110 -1.5 +120 + N/A -0.5 -105 + N/A -1.5 +120 + -0.5 even + N/A N/A -3 -110  
San Francisco 49ers 469 49ers
o48.5 -110 o13.5 even + N/A o13.5 -105 + N/A o13.5 +102 + o13.5 -110 + N/A N/A o45.5 -115  
Seattle Seahawks 470 Seahawks
u48.5 -110 u13.5 -130 + N/A u13.5 -125 + N/A u13.5 -124 + u13.5 -120 + N/A N/A u45.5 -105  
San Francisco 49ers 469 49ers
+170 even + N/A +105 + N/A +108 + N/A N/A N/A +136  
Seattle Seahawks 470 Seahawks
-205 -130 + N/A -135 + N/A -132 + N/A N/A N/A -162  

The Seattle Seahawks opened as a -3 point favorite to San Francisco. The total is set at over/under 45.5 total points scored by both teams combined.

Google Preferred Source

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the Polymarket promo code!

Updated on 10/8/26

bet365
Bet $10, Get $200 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $200
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Must be 21+ and physically present where bet365 operates. Please gamble responsibly. New customers only. Place qualifying bets of $10 or more to get $200 in Bonus Bets. Deposit required. Bonus bets are non-withdrawable and expire 7 days after receipt. Bonus bet wager excluded from returns. Time limits, min. Odds, and T&Cs apply. This code is used for marketing and tracking purposes only. Void where prohibited. Not eligible in IL, IN, TN, & WV.

49ers vs. Seahawks Prediction

This is more of a play against the 49ers than a play on the Seahawks. The 49ers won in Week 1 in Australia, which introduced some variables we don't see every week. In Week 2, they dominated a bad Dolphins team. In Week 3, they won a close game against Arizona. Last week, they beat the Broncos to end a 3-week home stretch.

Now they will be tested by playing a divisional team in their first game away from home since Week 1. Brock Purdy has been impressive, but he will face a tall task facing a Seahawks defense that ranks 4th in EPA allowed.

Updated on 10/8/26

Polymarket
Deposit $10, Get a $25 Trading Bonus!
Bonus Code
INSIDER
Claim $25
18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading is risky. 100% loss can occur. See polymarket.com/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated exchange and clearing organization.

49ers vs. Seahawks Prediction: Seattle Seahawks -3 (-110)

(Pick from Dylan Wilkerson)

Looking for more college football predictions? Check out our free NFL picks and our premium subscription for the best picks!

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•