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Featured Last Updated Oct 3 2025, 10:54 AM

New England Patriots vs. Buffalo Bills Week 5 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
New England Patriots vs. Buffalo Bills Week 5 Prediction: Odds, Best Bet

New England Patriots vs. Buffalo Bills Odds, NFL Week 5

Image Credit: Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

NE @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
New England Patriots 483 Patriots
+8.5 -110 +5.5 -110 + +4.5 -110 + +5.5 -112 + +5.5 -110 + +4.5 -115 + +5.5 -105 + +5.5 -110 + +5.5 -105 +4.5 -110 + +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 -5.5 -110 + -4.5 -110 + -5.5 -108 + -5.5 -110 + -4.5 -115 + -5.5 -115 + -5.5 -110 + -5.5 -115 -4.5 -113 + -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o24.5 even + N/A o24.5 -112 + o24.5 -105 + N/A o24.5 -105 + o24.5 -105 + o24.5 -110 o24.5 even + o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u24.5 -120 + N/A u24.5 -108 + u24.5 -115 + N/A u24.5 -115 + u24.5 -115 + u24.5 -110 u24.5 -124 + u49.5 -105  
New England Patriots 483 Patriots
+300 +225 + N/A +225 + +222 + +200 + +240 + N/A +230 +235 + +330  
Buffalo Bills 484 Bills
-380 -275 + N/A -270 + -278 + -280 + -310 + N/A -285 -305 + -425  
New England Patriots 483 Patriots
+8.5 -110 +0.5 -110 + +2.5 -115 + +1.5 -112 + +0.5 -115 + +1.5 -120 + +2.5 -110 + +1.5 -110 + +1.5 -115 +1.5 -113 + +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 -0.5 -110 + -2.5 -110 + -1.5 -108 + -0.5 -115 + -1.5 -110 + -2.5 -110 + -1.5 -110 + -1.5 -115 -1.5 -110 + -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o9.5 -125 + N/A o9.5 -125 + o9.5 -130 + o9.5 -125 + o9.5 -120 + o9.5 -120 + o8.5 -140 o9.5 -122 + o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u9.5 +105 + N/A u9.5 +105 + u9.5 even + u9.5 -105 + u9.5 -102 + u9.5 even + u8.5 +105 u9.5 even + u49.5 -105  
New England Patriots 483 Patriots
+300 +160 + N/A +160 + +155 + +150 + +172 + N/A +160 +165 + +330  
Buffalo Bills 484 Bills
-380 -190 + N/A -198 + -190 + -200 + -215 + N/A -210 -210 + -425  
New England Patriots 483 Patriots
+8.5 -110 +3.5 -110 + N/A +4.5 -120 + +3.5 -110 + N/A +3.5 -100 + N/A N/A +3.5 even + +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 -3.5 -110 + N/A -4.5 even + -3.5 -110 + N/A -3.5 -120 + N/A N/A -3.5 -124 + -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o23.5 -110 + N/A o24.5 -102 + o23.5 even N/A o23.5 -120 + o23.5 -125 + N/A o24.5 +104 + o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u23.5 -110 + N/A u24.5 -118 + u23.5 -120 N/A u23.5 -100 + u23.5 -105 + N/A u24.5 -129 + u49.5 -105  
New England Patriots 483 Patriots
+300 +160 + N/A +200 + N/A N/A +200 + N/A N/A +200 + +330  
Buffalo Bills 484 Bills
-380 -190 + N/A -238 + N/A N/A -245 + N/A N/A -250 + -425  
New England Patriots 483 Patriots
+8.5 -110 N/A N/A +3.5 -115 + N/A +3.5 -110 + +3.5 -120 + N/A N/A +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 N/A N/A -3.5 -105 + N/A -3.5 -110 + -3.5 -110 + N/A N/A -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o14.5 -105 + N/A o15.5 -112 + o15.5 -115 + N/A o15.5 -112 + o15.5 -115 + N/A N/A o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u14.5 -115 + N/A u15.5 -108 + u15.5 -105 + N/A u15.5 -108 + u15.5 -115 + N/A N/A u49.5 -105  
New England Patriots 483 Patriots
+300 +185 + N/A +195 + +190 + N/A +210 + N/A N/A N/A +330  
Buffalo Bills 484 Bills
-380 -230 + N/A -245 + -240 + N/A -265 + N/A N/A N/A -425  
New England Patriots 483 Patriots
+8.5 -110 N/A N/A +2.5 -108 + +2.5 -110 + N/A +2.5 -106 + +2.5 -110 + N/A N/A +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 N/A N/A -2.5 -112 + -2.5 -110 + N/A -2.5 -116 + -2.5 -120 + N/A N/A -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o9.5 -115 + N/A o10.5 +120 + o9.5 -140 + N/A o9.5 -148 + o9.5 -150 + N/A N/A o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u9.5 -105 + N/A u10.5 -142 + u9.5 +120 + N/A u9.5 +122 + u9.5 +115 + N/A N/A u49.5 -105  
New England Patriots 483 Patriots
+300 +170 + N/A +170 + +170 + N/A +176 + N/A N/A N/A +330  
Buffalo Bills 484 Bills
-380 -200 + N/A -205 + -200 + N/A -220 + N/A N/A N/A -425  
New England Patriots 483 Patriots
+8.5 -110 +0.5 -110 + N/A +2.5 -112 + +2.5 -105 + N/A +1.5 -110 + +2.5 even + N/A N/A +8.5 -115  
Buffalo Bills 484 Bills
-8.5 -110 -0.5 -110 + N/A -2.5 -108 + -2.5 -115 + N/A -1.5 -110 + -2.5 -130 + N/A N/A -8.5 -105  
New England Patriots 483 Patriots
o46.5 -110 o14 -110 + N/A o13.5 -112 + o13.5 -110 + N/A o13.5 -106 + o13.5 -110 + N/A N/A o49.5 -115  
Buffalo Bills 484 Bills
u46.5 -110 u14 -110 + N/A u13.5 -108 + u13.5 -110 + N/A u13.5 -116 + u13.5 -120 + N/A N/A u49.5 -105  
New England Patriots 483 Patriots
+300 +135 + N/A +150 + +160 + N/A +146 + N/A N/A N/A +330  
Buffalo Bills 484 Bills
-380 -160 + N/A -180 + -190 + N/A -180 + N/A N/A N/A -425  

The Patriots will take on the Bills in this week's NFL action. Kickoff is set for 8:20 p.m. EDT at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on NBC. Here's everything you need to know about Patriots vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -8.5 point favorite over Patriots. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/3/25

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New England Patriots vs. Buffalo Bills Best Bet

I love talking about the deep ball, so let's discuss one more matchup.

The Patriots have been one of the most vulnerable teams to deep shots through four weeks, and while Josh Allen hasn't aired it out all that much, he's been an efficient 6-of-13 on deep balls this season.

New England's secondary is in a bit of disarray, but the run defense looks like it could be legit with an eighth-place ranking in DVOA to this point. We know the Bills are going to run the ball — and they've done that quite well with the most rushing yards and touchdowns per game to this point — but they've also played a very weak schedule in this specific aspect of the game, and on their own end haven't been able to stop the run at all.

The Patriots might not be the flashiest team, but they're capable of hanging around with the Bills. This will be a battle of both front sevens, and in a game like that, they're much closer to the top half of the league than in any other scenario.

I expect some good, hard-nosed AFC East football and a surprisingly watchable game.

New England Patriots vs. Buffalo Bills Best Bet: Patriots +8.5

(Pick via Kenny Ducey)


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What Time is the New England Patriots vs. Buffalo Bills Game?

The New England Patriots and Buffalo Bills Game play at 4:25 PM ET on Sunday, October 5th.

Where is the New England Patriots vs. Buffalo Bills Game Being Played?

This game is going to be played at Highmark Stadium in Orchard Park, N.Y.

How Can I Watch the New England Patriots vs. Buffalo Bills?

You can watch New England Patriots vs. Buffalo Bills on NBC.

Can The Patriots Beat The Bills?

The Patriots are 8.5 point underdogs, but anything can happen in the NFL.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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