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Featured Last Updated Sep 25 2025, 1:08 PM

NFL: Browns vs. Lions, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Browns vs. Lions, Prediction, Odds, Best Bet

Featured Image Credit: Junfu Han via Imagn Images

CLE @ DET Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Cleveland Browns 261 Browns
+10.5 -112 +6.5 -110 + +5.5 -105 + +6.5 -118 + +5.5 even + +6.5 -120 + +6.5 -110 + +5.5 -105 +5.5 -107 + +6.5 -115 +10 -115  
Detroit Lions 262 Lions
-10.5 -108 -6.5 -110 + -5.5 -115 + -6.5 -102 + -5.5 -121 + -6.5 -110 + -6.5 -110 + -5.5 -115 -5.5 -117 + -6.5 -105 -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o22.5 -110 + N/A o22.5 -112 + o22.5 -109 N/A o22.5 -120 + o22.5 -110 o21.5 -110 + o22.5 -110 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u22.5 -110 + N/A u22.5 -108 + u22.5 -113 N/A u22.5 -100 + u22.5 -110 u21.5 -113 + u22.5 -110 u44.5 -115  
Cleveland Browns 261 Browns
+380 +270 + N/A +250 + +245 + +230 + +260 + +250 +255 + N/A +400  
Detroit Lions 262 Lions
-500 -340 + N/A -305 + -325 + -330 + -340 + -325 -335 + N/A -535  
Cleveland Browns 261 Browns
+10.5 -112 +2.5 +110 + +2.5 +110 + +2.5 +114 + N/A N/A +2.5 -106 + +1.5 +105 +2.5 -106 + +2.5 -105 +10 -115  
Detroit Lions 262 Lions
-10.5 -108 -2.5 -130 + -2.5 -140 + -2.5 -135 + N/A N/A -2.5 -116 + -1.5 -140 -2.5 -118 + -2.5 -115 -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o7.5 +110 + N/A o7.5 +102 + N/A N/A o7.5 -102 + o8.5 even o7.5 +102 + o7.5 even o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u7.5 -130 + N/A u7.5 -122 + N/A N/A u7.5 -120 + u8.5 -135 u7.5 -125 + u7.5 -120 u44.5 -115  
Cleveland Browns 261 Browns
+380 +230 + N/A +235 + +195 + N/A +186 + +220 +200 + N/A +400  
Detroit Lions 262 Lions
-500 -280 + N/A -285 + -240 + N/A -235 + -300 -265 + N/A -535  
Cleveland Browns 261 Browns
+10.5 -112 +4.5 -110 + N/A +4.5 -110 + +4.5 -115 + N/A +4.5 -120 + N/A +4.5 -107 + N/A +10 -115  
Detroit Lions 262 Lions
-10.5 -108 -4.5 -110 + N/A -4.5 -110 + -4.5 -105 + N/A -4.5 -100 + N/A -4.5 -117 + N/A -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o21.5 -110 + N/A o21.5 -112 + o21.5 -115 + N/A o21.5 -100 + N/A o21.5 -113 + o21.5 -115 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u21.5 -110 + N/A u21.5 -108 + u21.5 -105 + N/A u21.5 -120 + N/A u21.5 -110 + u21.5 -115 u44.5 -115  
Cleveland Browns 261 Browns
+380 +205 + N/A +230 + N/A N/A +210 + N/A +220 + N/A +400  
Detroit Lions 262 Lions
-500 -250 + N/A -285 + N/A N/A -260 + N/A -278 + N/A -535  
Cleveland Browns 261 Browns
+10.5 -112 N/A N/A +3.5 -130 + N/A N/A +3.5 -110 + N/A N/A +3.5 -115 +10 -115  
Detroit Lions 262 Lions
-10.5 -108 N/A N/A -3.5 +110 + N/A N/A -3.5 -110 + N/A N/A -3.5 -115 -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o13 -110 + N/A o13.5 -108 + N/A N/A o13.5 -116 + N/A N/A o13.5 -105 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u13 -110 + N/A u13.5 -112 + N/A N/A u13.5 -104 + N/A N/A u13.5 -125 u44.5 -115  
Cleveland Browns 261 Browns
+380 +220 + N/A +170 + N/A N/A +210 + N/A N/A N/A +400  
Detroit Lions 262 Lions
-500 -270 + N/A -205 + N/A N/A -265 + N/A N/A N/A -535  
Cleveland Browns 261 Browns
+10.5 -112 N/A N/A +2.5 even + N/A N/A +1.5 -110 + N/A N/A +2.5 -110 +10 -115  
Detroit Lions 262 Lions
-10.5 -108 N/A N/A -2.5 -120 + N/A N/A -1.5 -110 + N/A N/A -2.5 -120 -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o9.5 -110 + N/A o9.5 -110 + N/A N/A o8.5 -112 + N/A N/A o9.5 -115 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u9.5 -110 + N/A u9.5 -110 + N/A N/A u8.5 -108 + N/A N/A u9.5 -115 u44.5 -115  
Cleveland Browns 261 Browns
+380 +190 + N/A +180 + N/A N/A +176 + N/A N/A N/A +400  
Detroit Lions 262 Lions
-500 -230 + N/A -225 + N/A N/A -220 + N/A N/A N/A -535  
Cleveland Browns 261 Browns
+10.5 -112 +2.5 -110 + N/A +2.5 even + N/A N/A +2.5 -110 + N/A N/A N/A +10 -115  
Detroit Lions 262 Lions
-10.5 -108 -2.5 -110 + N/A -2.5 -120 + N/A N/A -2.5 -110 + N/A N/A N/A -10 -105  
Cleveland Browns 261 Browns
o45.5 -110 o12.5 -115 + N/A o12.5 -112 + N/A N/A o11.5 -110 + N/A N/A o12.5 -120 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u12.5 -105 + N/A u12.5 -108 + N/A N/A u11.5 -110 + N/A N/A u12.5 -110 u44.5 -115  
Cleveland Browns 261 Browns
+380 +165 + N/A +180 + N/A N/A +164 + N/A N/A N/A +400  
Detroit Lions 262 Lions
-500 -200 + N/A -218 + N/A N/A -205 + N/A N/A N/A -535  

The Browns will take on the Lions in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Ford Field in Detroit, Mich. The game will be broadcast live on FOX. Here's everything you need to know about Browns vs. Lions odds, the latest NFL spreads, NFL over/unders and more.

The Lions opened as a -9.5 point favorite over Browns. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Cleveland Browns vs. Detroit Lions Best Bet

Well, the Lions are back — and they may have never been missing in the first place.

This offense just ran wild on an elite run defense with David Montgomery and Jahmyr Gibbs scoring four times, and the line protected Jared Goff brilliantly in the face of heavy pressure.

Now comes the easy part, moving past the Browns — at least it should be.

The Browns stifled Green Bay's rushing attack and pressured Jordan Love 22 times, but I think the Lions have the Packers beat both on the line and in the backfield.

Montogmery and Gibbs are currently both inside PFF's top 12 rushers, and Josh Jacobs is averaging just a hair over three yards per carry with little support behind him on the depth chart.

We have to respect this Lions line after a brilliant performance against the Ravens, and we can't read too far into one win for Cleveland, which once again featured absolutely nothing on offense out of this weak, weak group.

Browns vs. Lions Best Bet: Lean Lions -9.5

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Cleveland Browns vs. Detroit Lions Game?

The Cleveland Browns vs. Detroit Lions at 1:00 PM ET on Sunday, September 28th.

Where is the Cleveland Browns vs. Detroit Lions Being Played?

This game will be played at Ford Field in Detroit, Michigan.

How Can I Watch Browns vs. Lions?

You can watch Browns vs. Lions on FOX.

Can the Browns Beat the Lions?

Yes, the Browns are coming off the biggest upset of the 2025 NFL season after beating the Green Bay Packers, 13-10.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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