Sign Up Subscribe
Featured

NFL: Browns vs. Lions, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Browns vs. Lions, Prediction, Odds, Best Bet

Featured Image Credit: Junfu Han via Imagn Images

CLE @ DET Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Cleveland Browns 261 Browns
+10.5 -112 +6.5 -115 +5.5 -102 +5.5 -105 +6.5 -117 +6.5 -110 +6.5 -110 +7.5 -125 +5.5 -107 +10 -110  
Detroit Lions 262 Lions
-10.5 -108 -6.5 -105 -5.5 -118 -5.5 -115 -6.5 -105 -6.5 -110 -6.5 -110 -7.5 +105 -5.5 -117 -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o23 -110 N/A o22.5 -110 o22.5 -113 o22.5 -120 o22.5 -120 o22.5 -125 o22.5 -124 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u23 -110 N/A u22.5 -110 u22.5 -106 u22.5 -100 u22.5 even u22.5 +105 u22.5 -103 u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +255 N/A +250 +255 +270 N/A +330 +245 +410  
Detroit Lions 262 Lions
-500 -330 N/A -310 -335 -370 N/A -425 -315 -535  
Final
Cleveland Browns 261 Browns
+10.5 -112 +2.5 +110 +2.5 +110 +2.5 +114 N/A +2.5 -102 +2.5 even +3.5 -120 +2.5 -107 +10 -110  
Detroit Lions 262 Lions
-10.5 -108 -2.5 -130 -2.5 -140 -2.5 -135 N/A -2.5 -120 -2.5 -130 -3.5 -110 -2.5 -117 -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o7.5 -110 N/A o7.5 +102 N/A o7.5 -110 o7.5 -110 o8.5 -135 o7.5 -108 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u7.5 -110 N/A u7.5 -122 N/A u7.5 -110 u7.5 -120 u8.5 even u7.5 -115 u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +205 N/A +230 +195 +194 N/A +300 +188 +410  
Detroit Lions 262 Lions
-500 -250 N/A -278 -240 -250 N/A -425 -245 -535  
Final
Cleveland Browns 261 Browns
+10.5 -112 +4.5 -105 N/A +4.5 -105 +4.5 -115 +4.5 -110 N/A N/A +5.5 -114 +10 -110  
Detroit Lions 262 Lions
-10.5 -108 -4.5 -115 N/A -4.5 -115 -4.5 -105 -4.5 -110 N/A N/A -5.5 -109 -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o20.5 -110 N/A o21.5 -105 o21.5 -115 o21.5 -100 o21.5 -110 N/A o22.5 -104 o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u20.5 -110 N/A u21.5 -115 u21.5 -105 u21.5 -120 u21.5 -120 N/A u22.5 -121 u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +230 N/A +235 N/A +235 N/A N/A +215 +410  
Detroit Lions 262 Lions
-500 -280 N/A -290 N/A -280 N/A N/A -278 -535  
Final
Cleveland Browns 261 Browns
+10.5 -112 N/A N/A +2.5 +110 N/A +3.5 -106 +3.5 -115 N/A N/A +10 -110  
Detroit Lions 262 Lions
-10.5 -108 N/A N/A -2.5 -130 N/A -3.5 -116 -3.5 -115 N/A N/A -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o13.5 -110 N/A o13.5 -108 N/A o9.5 -110 o13.5 -105 N/A N/A o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u13.5 -110 N/A u13.5 -112 N/A u9.5 -120 u13.5 -125 N/A N/A u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +205 N/A +180 N/A +225 N/A N/A N/A +410  
Detroit Lions 262 Lions
-500 -250 N/A -225 N/A -290 N/A N/A N/A -535  
Final
Cleveland Browns 261 Browns
+10.5 -112 N/A N/A +2.5 even N/A +2.5 -108 +2.5 -105 N/A N/A +10 -110  
Detroit Lions 262 Lions
-10.5 -108 N/A N/A -2.5 -120 N/A -2.5 -116 -2.5 -125 N/A N/A -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o7.5 -110 N/A o9.5 -110 N/A o3.5 +245 o9.5 -110 N/A N/A o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u7.5 -110 N/A u9.5 -110 N/A u3.5 -360 u9.5 -120 N/A N/A u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +205 N/A +190 N/A +184 N/A N/A N/A +410  
Detroit Lions 262 Lions
-500 -250 N/A -230 N/A -225 N/A N/A N/A -535  
Final
Cleveland Browns 261 Browns
+10.5 -112 +3 -115 N/A +2.5 +102 N/A +2.5 -106 +3.5 -130 N/A N/A +10 -110  
Detroit Lions 262 Lions
-10.5 -108 -3 -105 N/A -2.5 -125 N/A -2.5 -116 -3.5 even N/A N/A -10 -110  
Final
Cleveland Browns 261 Browns
o45.5 -110 o11.5 -110 N/A o12.5 -110 N/A o11.5 -112 o12.5 -120 N/A N/A o44.5 -105  
Detroit Lions 262 Lions
u45.5 -110 u11.5 -110 N/A u12.5 -110 N/A u11.5 -108 u12.5 -110 N/A N/A u44.5 -115  
Final
Cleveland Browns 261 Browns
+380 +180 N/A +185 N/A +176 N/A N/A N/A +410  
Detroit Lions 262 Lions
-500 -220 N/A -225 N/A -215 N/A N/A N/A -535  

The Browns will take on the Lions in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Ford Field in Detroit, Mich. The game will be broadcast live on FOX. Here's everything you need to know about Browns vs. Lions odds, the latest NFL spreads, NFL over/unders and more.

The Lions opened as a -9.5 point favorite over Browns. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 1/27/26

bet365
Bet $5, Get $200 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $200
Deposit Required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers Only. T&Cs, time limits, and exclusions apply. 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, MO, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $200 in Bonus Bets at bet365. Minimum odds -500 of greater.

Cleveland Browns vs. Detroit Lions Best Bet

Well, the Lions are back — and they may have never been missing in the first place.

This offense just ran wild on an elite run defense with David Montgomery and Jahmyr Gibbs scoring four times, and the line protected Jared Goff brilliantly in the face of heavy pressure.

Now comes the easy part, moving past the Browns — at least it should be.

The Browns stifled Green Bay's rushing attack and pressured Jordan Love 22 times, but I think the Lions have the Packers beat both on the line and in the backfield.

Montogmery and Gibbs are currently both inside PFF's top 12 rushers, and Josh Jacobs is averaging just a hair over three yards per carry with little support behind him on the depth chart.

We have to respect this Lions line after a brilliant performance against the Ravens, and we can't read too far into one win for Cleveland, which once again featured absolutely nothing on offense out of this weak, weak group.

Browns vs. Lions Best Bet: Lean Lions -9.5

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Cleveland Browns vs. Detroit Lions Game?

The Cleveland Browns vs. Detroit Lions at 1:00 PM ET on Sunday, September 28th.

Where is the Cleveland Browns vs. Detroit Lions Being Played?

This game will be played at Ford Field in Detroit, Michigan.

How Can I Watch Browns vs. Lions?

You can watch Browns vs. Lions on FOX.

Can the Browns Beat the Lions?

Yes, the Browns are coming off the biggest upset of the 2025 NFL season after beating the Green Bay Packers, 13-10.

Featured News

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
•