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Featured Last Updated Sep 5 2025, 1:51 PM

NFL: Cardinals vs. Saints, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Cardinals vs. Saints, Prediction, Odds, Best Bet

Featured Image Credit: Patrick Breen/USA Today Network via Imagn Images

ARI @ NO Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Arizona Cardinals 467 Cardinals
-3.5 -115 -3.5 -110 + -3.5 -115 + -3.5 -110 + -3.5 -110 + -3.5 -115 + -3.5 -110 + -4.5 +110 -3.5 -106 + -3.5 -106 -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 +3.5 -110 + +3.5 -105 + +3.5 -110 + +3.5 -110 + +3.5 -115 + +3.5 -110 + +4.5 -140 +3.5 -118 + +3.5 -118 +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 N/A N/A N/A N/A N/A N/A o8.5 -120 N/A N/A o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 N/A N/A N/A N/A N/A N/A u8.5 -110 N/A N/A u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -214 + -220 + -205 + -210 + -220 + -215 + -225 -215 + -215 -298  
New Orleans Saints 468 Saints
+160 +175 + +180 + +170 + +175 + +160 + +172 + +185 +170 + +170 +240  
Arizona Cardinals 467 Cardinals
-3.5 -115 -0.5 +105 + -0.5 -110 + -0.5 +105 + -0.5 even + -0.5 even + -1.5 +106 + -0.5 -110 -1.5 +104 + -1.5 +104 -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 +0.5 -125 + +0.5 -118 + +0.5 -125 + +0.5 -130 + +0.5 -130 + +1.5 -128 + +0.5 -120 +1.5 -129 + +1.5 -129 +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 o7.5 +110 + N/A o7.5 +102 + o7.5 even + o7.5 -110 + o7.5 +112 + o8.5 +115 o7.5 +102 + o7.5 +102 o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 u7.5 -131 + N/A u7.5 -122 + u7.5 -130 + u7.5 -120 + u7.5 -136 + u8.5 -150 u7.5 -127 + u7.5 -127 u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -173 + -190 + -166 + -170 + -160 + -176 + -190 -180 + -180 -298  
New Orleans Saints 468 Saints
+160 +145 + +150 + +140 + +140 + +125 + +142 + +145 +143 + +143 +240  
Arizona Cardinals 467 Cardinals
-3.5 -115 -3.5 -105 + N/A -3.5 -102 + -2.5 -125 + N/A -2.5 -125 + N/A -3.5 +102 + -3.5 +102 -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 +3.5 -115 + N/A +3.5 -118 + +2.5 +105 + N/A +2.5 +105 + N/A +3.5 -125 + +3.5 -125 +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 o21.5 +105 + N/A o21.5 -108 + o21.5 -115 + N/A o20.5 -110 + N/A o20.5 -113 + o20.5 -113 o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 u21.5 -125 + N/A u21.5 -112 + u21.5 -105 + N/A u20.5 -110 + N/A u20.5 -110 + u20.5 -110 u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -209 + N/A -205 + N/A N/A -190 + N/A -200 + -200 -298  
New Orleans Saints 468 Saints
+160 +170 + N/A +170 + N/A N/A +160 + N/A +160 + +160 +240  
Arizona Cardinals 467 Cardinals
-3.5 -115 N/A N/A -2.5 -118 + -2.5 -115 + N/A -2.5 -116 + N/A N/A N/A -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 N/A N/A +2.5 -102 + +2.5 -105 + N/A +2.5 -106 + N/A N/A N/A +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 o13.5 +110 + N/A o12.5 -135 + o13.5 even + N/A o13.5 -102 + N/A N/A N/A o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 u13.5 -131 + N/A u12.5 +114 + u13.5 -120 + N/A u13.5 -120 + N/A N/A N/A u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -193 + N/A -192 + -190 + N/A -188 + N/A N/A N/A -298  
New Orleans Saints 468 Saints
+160 +160 + N/A +160 + +158 + N/A +152 + N/A N/A N/A +240  
Arizona Cardinals 467 Cardinals
-3.5 -115 N/A N/A -0.5 -108 + -1.5 +105 + N/A -1.5 +104 + N/A N/A N/A -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 N/A N/A +0.5 -112 + +1.5 -125 + N/A +1.5 -128 + N/A N/A N/A +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 o8.5 -110 + N/A o9.5 -108 + o8.5 -110 + N/A o7.5 -110 + N/A N/A N/A o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 u8.5 -110 + N/A u9.5 -112 + u8.5 -110 + N/A u7.5 -112 + N/A N/A N/A u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -183 + N/A -180 + -175 + N/A -172 + N/A N/A N/A -298  
New Orleans Saints 468 Saints
+160 +150 + N/A +150 + +148 + N/A +140 + N/A N/A N/A +240  
Arizona Cardinals 467 Cardinals
-3.5 -115 -0.5 -120 + N/A -1.5 -110 + -1.5 even + N/A -1.5 +102 + N/A N/A N/A -6.5 -110  
New Orleans Saints 468 Saints
+3.5 -105 +0.5 even + N/A +1.5 -110 + +1.5 -120 + N/A +1.5 -124 + N/A N/A N/A +6.5 -110  
Arizona Cardinals 467 Cardinals
o43.5 -115 o12.5 -105 + N/A o12.5 -115 + o11.5 -110 + N/A o11.5 -110 + N/A N/A N/A o43.5 -108  
New Orleans Saints 468 Saints
u43.5 -105 u12.5 -115 + N/A u12.5 -105 + u11.5 -110 + N/A u11.5 -110 + N/A N/A N/A u43.5 -112  
Arizona Cardinals 467 Cardinals
-192 -173 + N/A -170 + -165 + N/A -162 + N/A N/A N/A -298  
New Orleans Saints 468 Saints
+160 +145 + N/A +142 + +140 + N/A +132 + N/A N/A N/A +240  

The Cardinals will take on the Saints in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Caesars Superdome in New Orleans, La. The game will be broadcast live on CBS. Here's everything you need to know about Cardinals vs. Saints odds, the latest NFL spreads, NFL over/unders and more.

The Cardinals opened as a -6.5 point favorite over Saints. The total is set at over/under 43 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Arizona Cardinals vs. New Orleans Saints Best Bet

James Conner's line looks a little low to start the season, with the Cardinals big favorites against what looks like the league's worst team in the Saints. Not only should the Saints struggle on offense this season, but the defense looks equally as bad, with little to no improvement in the offseason. They spent no draft capital in the 1st or 2nd round on defense, and the only major addition was safety Justin Reid in free agency.

Conner always seems to be undervalued, even though he still produces at an elite level. Of full-time RBs last season, he was 2nd in missed tackles forced per attempt, was 11th in yards after contact, and averaged 68.5 rushing yards per game. I wonder why his prop is at 68.5... The books do silly things like take season averages into account more than they should, but for this game, we are looking back at the games in which Arizona won. He averaged 87.4 rushing yards in games Arizona won last season, and as heavy favorites, I'm looking for him to easily blow past this line.

Cardinals vs. Saints Best Bet: James Conner Over 68.5 Rushing Yards

(Pick from Brit Devine)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Arizona Cardinals vs. New Orleans Saints Game?

The Arizona Cardinals will take on the New Orleans Saints at 1:00 ET on Sunday, September 7th.

Where is the Arizona Cardinals vs. New Orleans Saints Game Being Played?

This game is going to be played at the Caesars Superdome in New Orleans, Lousiana.

How Can I Watch Cardinals vs. Saints?

You can watch Cardinals vs. Saints on CBS.

Can the Saints Beat the Cardinals?

It will certainly be a tough task as the Saints have the second-lowest implied win total heading into the 2025-26 season. However, just last year we saw the New England Patriots overtake the Cincinnati Bengals in their opener as seven-point underdogs.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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