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Featured Last Updated Nov 20 2025, 1:44 PM

NFL: Kansas City Chiefs vs. Indianapolis Colts: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
NFL: Kansas City Chiefs vs. Indianapolis Colts: Prediction, Odds, Preview

Featured Image Credit: Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

IND @ KC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indianapolis Colts 253 Colts
+9.5 -110 +2.5 -110 + +1.5 -115 + +1.5 -108 + +1.5 -114 + +1.5 -120 + +0.5 -105 + +1.5 -110 +1.5 -124 + +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 -2.5 -110 + -1.5 -105 + -1.5 -112 + -1.5 -106 + -1.5 -100 + -0.5 -115 + -1.5 -110 -1.5 even + -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o24.5 -110 + o25.5 -110 + o25.5 -112 + o24.5 -118 + o25.5 -105 + o24.5 -110 + o24.5 -115 o25.5 -113 + o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u24.5 -110 + u25.5 -110 + u25.5 -108 + u24.5 -103 + u25.5 -115 + u24.5 -110 + u24.5 -105 u25.5 -110 + u50.5 -112  
Indianapolis Colts 253 Colts
+330 +130 + +115 + +124 + +117 + +110 + N/A +115 +112 + +154  
Kansas City Chiefs 254 Chiefs
-425 -155 + -140 + -148 + -141 + -134 + N/A -140 -141 + -185  
Indianapolis Colts 253 Colts
+9.5 -110 +0.5 -160 + +0.5 -175 + +0.5 -155 + N/A -1.5 +144 + -0.5 +140 + -0.5 +140 -1.5 +143 + +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 -0.5 +135 + -0.5 +135 + -0.5 +130 + N/A +1.5 -178 + +0.5 -170 + +0.5 -170 +1.5 -180 + -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o9.5 -125 + o9.5 -135 + o9.5 -130 + N/A o9.5 -136 + o9.5 -130 + o8.5 -150 o9.5 -134 + o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u9.5 +105 + u9.5 +105 + u9.5 +110 + N/A u9.5 +110 + u9.5 +110 + u8.5 +110 u9.5 +108 + u50.5 -112  
Indianapolis Colts 253 Colts
+330 even + -115 + -102 + N/A -114 + N/A -115 -114 + +154  
Kansas City Chiefs 254 Chiefs
-425 -120 + -110 + -118 + N/A -106 + N/A -115 -109 + -185  
Indianapolis Colts 253 Colts
+9.5 -110 +1 -110 + N/A +2.5 -120 + N/A +2.5 -110 + N/A N/A +2.5 -113 + +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 -1 -110 + N/A -2.5 -110 + N/A -2.5 -110 + N/A N/A -2.5 -110 + -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o24.5 -105 + N/A o24.5 +102 + N/A o23.5 -120 + o23.5 -130 + N/A o23.5 -118 + o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u24.5 -115 + N/A u24.5 -122 + N/A u23.5 -100 + u23.5 even + N/A u23.5 -105 + u50.5 -112  
Indianapolis Colts 253 Colts
+330 +110 + N/A +130 + N/A +142 + N/A N/A +145 + +154  
Kansas City Chiefs 254 Chiefs
-425 -130 + N/A -166 + N/A -166 + N/A N/A -186 + -185  
Indianapolis Colts 253 Colts
+9.5 -110 N/A N/A +1.5 -120 + N/A +1.5 -122 + +0.5 -110 + N/A N/A +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 N/A N/A -1.5 -110 + N/A -1.5 -100 + -0.5 -120 + N/A N/A -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o14 -110 + N/A o15.5 -115 + N/A o15.5 -116 + o15.5 -120 + N/A N/A o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u14 -110 + N/A u15.5 -115 + N/A u15.5 -106 + u15.5 -110 + N/A N/A u50.5 -112  
Indianapolis Colts 253 Colts
+330 +120 + N/A +124 + N/A +122 + N/A N/A N/A +154  
Kansas City Chiefs 254 Chiefs
-425 -140 + N/A -160 + N/A -148 + N/A N/A N/A -185  
Indianapolis Colts 253 Colts
+9.5 -110 N/A N/A +0.5 -120 + N/A +1.5 -116 + +0.5 -115 + N/A N/A +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 N/A N/A -0.5 -110 + N/A -1.5 -106 + -0.5 -115 + N/A N/A -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o10 -110 + N/A o9.5 -145 + N/A o9.5 -134 + o9.5 -140 + N/A N/A o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u10 -110 + N/A u9.5 +114 + N/A u9.5 +110 + u9.5 +110 + N/A N/A u50.5 -112  
Indianapolis Colts 253 Colts
+330 +110 + N/A +130 + N/A +152 + N/A N/A N/A +154  
Kansas City Chiefs 254 Chiefs
-425 -130 + N/A -166 + N/A -188 + N/A N/A N/A -185  
Indianapolis Colts 253 Colts
+9.5 -110 +0.5 -130 + N/A +0.5 -125 + N/A +1.5 -148 + N/A N/A N/A +3.5 -115  
Kansas City Chiefs 254 Chiefs
-9.5 -110 -0.5 +110 + N/A -0.5 -105 + N/A -1.5 +122 + N/A N/A N/A -3.5 -105  
Indianapolis Colts 253 Colts
o45.5 -110 o14.5 -110 + N/A o13.5 -120 + N/A o13.5 -112 + o13.5 -120 + N/A N/A o50.5 -108  
Kansas City Chiefs 254 Chiefs
u45.5 -110 u14.5 -110 + N/A u13.5 -110 + N/A u13.5 -108 + u13.5 -110 + N/A N/A u50.5 -112  
Indianapolis Colts 253 Colts
+330 even + N/A +105 + N/A +104 + N/A N/A N/A +154  
Kansas City Chiefs 254 Chiefs
-425 -120 + N/A -135 + N/A -128 + N/A N/A N/A -185  

The Colts will take on the Chiefs in this week's NFL action. Kickoff is set for 1:00 p.m. EST at GEHA Field at Arrowhead Stadium in Kansas City, Mo. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Chiefs odds, the latest NFL spreads, NFL over/unders and more.

The Chiefs opened as a -3.5 point favorite over Colts. The total is set at over/under 50.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos when Missouri sports betting goes live.

Kansas City Chiefs vs. Indianapolis Colts Prediction

The Colts enter this matchup allowing 20.6 points per game, while the Chiefs are averaging 25.4 points per game offensively. The Colts have been effective running the ball, gaining 145.3 rushing yards per game, which could help control the clock against the Chiefs' passing attack. The Colts’ defense has generated nearly 3 sacks per game and 14 turnovers on the season, creating potential for momentum shifts. Time of possession and rushing efficiency could be key factors in keeping the game close.

Kansas City Chiefs vs. Indianapolis Colts Prediction: Colts moneyline (+156)

(Pick from Dylan Wilkerson)

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What Time is the Kansas City Chiefs vs. Indianapolis Colts Game?

The Kansas City Chiefs vs. Indianapolis Colts game is at 1:00 PM ET on Sunday, November 23rd.

Where is the Kansas City Chiefs vs. Indianapolis Colts Game Being Played?

This game will be played at GEHA Field at Arrowhead Stadium in Kansas City, Mo.

How Can I Watch Kansas City Chiefs vs. Indianapolis Colts?

You can watch Kansas City Chiefs vs. Indianapolis Colts on CBS.

Can the Colts Beat the Chiefs?

Of course! The Colts are a 3.5 point underdog, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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