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Featured Last Updated Sep 17 2025, 10:38 AM

Thursday Night Football: Dolphins vs. Bills, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Thursday Night Football: Dolphins vs. Bills, Prediction, Odds, Best Bet

Image Credit: Robert Deutsch/USA Today Network via Imagn Images

MIA @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Miami Dolphins 301 Dolphins
+8.5 -110 +7.5 -120 + +7.5 -120 + +7.5 -115 + +7 -110 + N/A +7.5 -125 + +7.5 -125 +6.5 +106 + +6.5 +106 +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 -7.5 even + -7.5 even + -7.5 -105 + -7 -110 + N/A -7.5 +105 + -7.5 +105 -6.5 -130 + -6.5 -130 -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o25.5 -120 + N/A o25.5 -115 + o25.5 -115 + N/A o25.5 -120 + o24.5 -115 o25.5 -118 + o25.5 -118 o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u25.5 even + N/A u25.5 -105 + u25.5 -105 + N/A u25.5 -100 + u24.5 -105 u25.5 -106 + u25.5 -106 u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +325 + N/A +340 + +320 + N/A +310 + +310 +325 + +325 +575  
Buffalo Bills 302 Bills
-380 -425 + N/A -440 + -420 + N/A -430 + -400 -455 + -455 -850  
Miami Dolphins 301 Dolphins
+8.5 -110 +3.5 -125 + +3.5 -130 + +3.5 -130 + +3.5 -130 + N/A +3.5 -134 + +3.5 -125 +3.5 -134 + +3.5 -134 +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 -3.5 +105 + -3.5 even + -3.5 +110 + -3.5 even + N/A -3.5 +110 + -3.5 -105 -3.5 +108 + -3.5 +108 -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o9.5 -125 + N/A o9.5 -135 + o9.5 -135 + N/A o9.5 -134 + o8.5 -150 o10.5 +128 + o10.5 +128 o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u9.5 +105 + N/A u9.5 +114 + u9.5 +105 + N/A u9.5 +110 + u8.5 +115 u10.5 -159 + u10.5 -159 u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +230 + N/A +210 + +225 + N/A +210 + +200 +215 + +215 +575  
Buffalo Bills 302 Bills
-380 -280 + N/A -258 + -280 + N/A -265 + -275 -278 + -278 -850  
Miami Dolphins 301 Dolphins
+8.5 -110 +5.5 -105 + N/A +5.5 -102 + +5.5 -105 + N/A +5.5 -110 + N/A +5.5 -104 + +5.5 -104 +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 -5.5 -115 + N/A -5.5 -118 + -5.5 -115 + N/A -5.5 -110 + N/A -5.5 -120 + -5.5 -120 -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o23.5 -120 + N/A o23.5 -110 + o23.5 -105 + N/A o23.5 -120 + N/A o23.5 -122 + o23.5 -122 o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u23.5 even + N/A u23.5 -110 + u23.5 -115 + N/A u23.5 -100 + N/A u23.5 -103 + u23.5 -103 u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +260 + N/A +260 + N/A N/A +250 + N/A +270 + +270 +575  
Buffalo Bills 302 Bills
-380 -320 + N/A -325 + N/A N/A -320 + N/A -360 + -360 -850  
Miami Dolphins 301 Dolphins
+8.5 -110 N/A N/A +4.5 -115 + +3.5 +105 + N/A +3.5 +104 + N/A N/A N/A +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 N/A N/A -4.5 -105 + -3.5 -125 + N/A -3.5 -128 + N/A N/A N/A -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o15.5 -110 + N/A o15.5 -118 + o15.5 -120 + N/A o15.5 -122 + N/A N/A N/A o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u15.5 -110 + N/A u15.5 -102 + u15.5 even + N/A u15.5 -100 + N/A N/A N/A u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +240 + N/A +270 + +240 + N/A +245 + N/A N/A N/A +575  
Buffalo Bills 302 Bills
-380 -310 + N/A -340 + -310 + N/A -320 + N/A N/A N/A -850  
Miami Dolphins 301 Dolphins
+8.5 -110 N/A N/A +3.5 -122 + +3.5 -130 + N/A +3.5 -132 + N/A N/A N/A +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 N/A N/A -3.5 +102 + -3.5 +110 + N/A -3.5 +108 + N/A N/A N/A -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o10 even + N/A o10.5 +120 + o10.5 +110 + N/A o10.5 +112 + N/A N/A N/A o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u10 -120 + N/A u10.5 -142 + u10.5 -130 + N/A u10.5 -136 + N/A N/A N/A u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +195 + N/A +215 + +210 + N/A +210 + N/A N/A N/A +575  
Buffalo Bills 302 Bills
-380 -240 + N/A -265 + -260 + N/A -265 + N/A N/A N/A -850  
Miami Dolphins 301 Dolphins
+8.5 -110 +1.5 -110 + N/A +2.5 +102 + +2.5 even + N/A +2.5 -104 + N/A N/A N/A +12.5 -108  
Buffalo Bills 302 Bills
-8.5 -110 -1.5 -110 + N/A -2.5 -125 + -2.5 -120 + N/A -2.5 -118 + N/A N/A N/A -12.5 -112  
Miami Dolphins 301 Dolphins
o48.5 -110 o12 -110 + N/A o13.5 +105 + o13.5 -105 + N/A o13.5 -106 + N/A N/A N/A o49.5 -112  
Buffalo Bills 302 Bills
u48.5 -110 u12 -110 + N/A u13.5 -125 + u13.5 -115 + N/A u13.5 -116 + N/A N/A N/A u49.5 -108  
Miami Dolphins 301 Dolphins
+300 +160 + N/A +180 + +175 + N/A +172 + N/A N/A N/A +575  
Buffalo Bills 302 Bills
-380 -185 + N/A -218 + -215 + N/A -215 + N/A N/A N/A -850  

The Dolphins will take on the Bills in this week's NFL action. Kickoff is set for 8:15 p.m. EDT at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on Amazon Prime Video. Here's everything you need to know about Dolphins vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -12.5 point favorite over Dolphins. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Miami Dolphins vs. Buffalo Bills Best Bet

To open the week three slate, we have two teams heading in opposite directions.

The 2-0 Buffalo Bills will host the lifeless 0-2 Dolphins. Miami head coach Mike McDaniel seems to be sitting firmly on the hot seat as another lackluster performance may push owner Stephen Ross to fire him going into the mini-bye.

The Bills will look to replicate their week two performance with another convincing win over a division opponent on the short week.

For this matchup, I'm keying in on Bills' running back James Cook who is coming off a strong 132-yard performance on 21 carries.

This is still a committee where Cook will receive less than 50% of the snap share. On a short week, look for the Bills to attack through the air early against a putrid Miami secondary and lean on the run late in a positive game script.

Off a 21-carry performance, the Bills should look to limit Cook's workload on TNF with more Ray Davis in the mix.

Dolphins vs. Bills Best Bet: James Cook Under 15.5 rushing attempts

(Pick from Derek Mountain)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Miami Dolphins vs. Buffalo Bills Game?

The Miami Dolphins will take on the Buffalo Bills at 8:15 ET on Thursday, September 18th.

Where is the Miami Dolphins vs. Buffalo Bills Game Being Played?

This game is going to be played at Highmark Stadium in Orchard Park, New York.

How Can I Watch Miami vs. Buffalo?

You can watch Dolphins vs. Bills on Amazon Prime.

Can the Dolphins beat the Bills?

To date, the 12.5-point spread is tied for the largest of the 2025 regular season. In the NFL, anything is possible, but it'll take a miraculous effort for Miami to beat the Buffalo Bills this Thursday night.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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