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Featured Last Updated Jan 13 2026, 12:06 PM

NFL Divisional Round: San Francisco 49ers vs. Seattle Seahawks Prediction, Odds, Preview

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
NFL Divisional Round: San Francisco 49ers vs. Seattle Seahawks Prediction, Odds, Preview

Featured Image Credit: Sergio Estrada via Imagn Images

SF @ SEA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 389 49ers
+7 -110 +4 -110 + +4.5 -115 + +4.5 -120 + +4.5 -117 + +4.5 -120 + +3.5 even + +5.5 -125 + +4.5 -117 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 -4 -110 + -4.5 -105 + -4.5 even + -4.5 -104 + -4.5 -100 + -3.5 -120 + -5.5 +105 + -4.5 -107 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o23 even + o22.5 -110 + o22.5 -118 + o22.5 -117 + o23.5 +120 + o22.5 -115 + o22.5 -110 + o23.5 even + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u23 -120 + u22.5 -110 + u22.5 -102 + u22.5 -104 + u23.5 -140 + u22.5 -105 + u22.5 -110 + u23.5 -124 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +205 + +220 + +200 + +215 + +215 + N/A +210 + +215 + +280  
Seattle Seahawks 390 Seahawks
-340 -250 + -275 + -238 + -265 + -270 + N/A -260 + -278 + -355  
San Francisco 49ers 389 49ers
+7 -110 +2.5 -110 + +2.5 -120 + +2.5 -108 + N/A +1.5 -116 + +0.5 -110 + +1.5 -110 + +1.5 -114 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 -2.5 -110 + -2.5 -105 + -2.5 -112 + N/A -1.5 -106 + -0.5 -110 + -1.5 -110 + -1.5 -109 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o9.5 -105 + o9.5 even + o8.5 -112 + N/A o8.5 -116 + o8.5 -110 + o8.5 -115 + o9.5 -112 + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u9.5 -115 + u9.5 -130 + u8.5 -108 + N/A u8.5 -106 + u8.5 -110 + u8.5 -115 + u9.5 -112 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +175 + +150 + +185 + N/A +164 + N/A +160 + +160 + +280  
Seattle Seahawks 390 Seahawks
-340 -210 + -190 + -218 + N/A -205 + N/A -210 + -205 + -355  
San Francisco 49ers 389 49ers
+7 -110 +3.5 -110 + N/A +3.5 -105 + N/A +3.5 -115 + N/A N/A +3.5 -112 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 -3.5 -110 + N/A -3.5 -125 + N/A -3.5 -105 + N/A N/A -3.5 -112 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o21.5 -110 + N/A o22.5 -110 + N/A o20.5 -120 + N/A N/A o21.5 -113 + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u21.5 -110 + N/A u22.5 -110 + N/A u20.5 -100 + N/A N/A u21.5 -110 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +195 + N/A +195 + N/A +186 + N/A N/A +185 + +280  
Seattle Seahawks 390 Seahawks
-340 -240 + N/A -260 + N/A -220 + N/A N/A -235 + -355  
San Francisco 49ers 389 49ers
+7 -110 N/A N/A +2.5 -105 + N/A +2.5 +110 + N/A N/A +3.5 -132 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 N/A N/A -2.5 -125 + N/A -2.5 -134 + N/A N/A -3.5 +107 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o13.5 even + N/A o13.5 -110 + N/A o13.5 -110 + N/A N/A o13.5 -120 + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u13.5 -120 + N/A u13.5 -120 + N/A u13.5 -110 + N/A N/A u13.5 -105 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +160 + N/A +150 + N/A +180 + N/A N/A +185 + +280  
Seattle Seahawks 390 Seahawks
-340 -190 + N/A -188 + N/A -230 + N/A N/A -235 + -355  
San Francisco 49ers 389 49ers
+7 -110 N/A N/A +2.5 -115 + N/A +1.5 -114 + N/A N/A +1.5 -118 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 N/A N/A -2.5 -115 + N/A -1.5 -106 + N/A N/A -1.5 -106 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o9.5 -120 + N/A o9.5 -120 + N/A o9.5 -106 + N/A N/A o9.5 -110 + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u9.5 even + N/A u9.5 -110 + N/A u9.5 -116 + N/A N/A u9.5 -113 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +175 + N/A +160 + N/A +158 + N/A N/A +155 + +280  
Seattle Seahawks 390 Seahawks
-340 -210 + N/A -215 + N/A -196 + N/A N/A -195 + -355  
San Francisco 49ers 389 49ers
+7 -110 +2.5 -105 + N/A +2.5 -110 + N/A +1.5 -112 + N/A N/A +2.5 -114 + +7.5 -115  
Seattle Seahawks 390 Seahawks
-7 -110 -2.5 -115 + N/A -2.5 -120 + N/A -1.5 -108 + N/A N/A -2.5 -109 + -7.5 -105  
San Francisco 49ers 389 49ers
o46.5 -110 o12.5 -120 + N/A o12.5 -125 + N/A o12.5 -110 + N/A N/A o12.5 -117 + o44.5 -115  
Seattle Seahawks 390 Seahawks
u46.5 -110 u12.5 even + N/A u12.5 -105 + N/A u12.5 -114 + N/A N/A u12.5 -107 + u44.5 -105  
San Francisco 49ers 389 49ers
+270 +165 + N/A +154 + N/A +146 + N/A N/A +155 + +280  
Seattle Seahawks 390 Seahawks
-340 -200 + N/A -200 + N/A -176 + N/A N/A -195 + -355  

The 49ers will take on the Seahawks in this week's NFL action. Kickoff is set for 8:00 p.m. EST at Lumen Field in Seattle, WA, Wash. The game will be broadcast live on FOX. Here's everything you need to know about 49ers vs. Seahawks odds, the latest NFL spreads, NFL over/unders and more.

The Seahawks opened as a -7.5 point favorite over 49ers. The total is set at over/under 45.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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San Francisco 49ers vs. Seattle Seahawks Prediction

I usually lean toward overs in the Divisional Round, especially when San Francisco is involved. But this matchup requires looking beneath the surface.

These teams played just two weeks ago, and Seattle won 13-3. That wasn’t a fluke.

San Francisco posted a 36% success rate, just 173 total yards and only three points — the lowest output of Kyle Shanahan’s tenure dating back to his 2017 debut.

The Niners finished with nine first downs and were completely shut down on late downs (2-for-11) and in the red zone (0-for-1), areas where they’re typically elite.

This is exactly why Seattle went out and hired Mike Macdonald. His defenses are built to handle Shanahan and McVay-style offenses.

Seattle currently ranks No. 1 in defensive DVOA, top two against both the run and the pass, and top seven versus the middle of the field, motion, play action and under-center looks — all core Shanahan strengths.

That performance wasn’t an outlier for San Francisco’s offense against real defenses. Since Brock Purdy returned, the 49ers have played four games against defenses ranked 20th or worse in DVOA and four against better units.

Against the weaker defenses, San Francisco posted a 54% success rate and averaged nearly 70 points per game. Against top defenses, that drops to a 40% success rate with just 30.3 points per game, topping out at 42.

Now layer in the injury concerns: George Kittle is out, Trent Williams is questionable, and the supporting cast continues to take hits. This is not an offense at full strength.

Seattle’s offense isn’t exactly humming either. Since the Week 11 game against the Rams, the Seahawks have fallen from No. 1 in pass DVOA to No. 25. They’ve quietly been one of the league’s best under teams, especially early — 13–4 to the under in first half.

This total mirrors San Francisco’s opener against Philadelphia, which opened higher and closed at 44. Expect similar market movement here. At 45.5, the value is on the under.

San Francisco 49ers vs. Seattle Seahawks Prediction: Under 45.5

(Pick from Brandon Anderson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the San Francisco 49ers vs. Seattle Seahawks Game?

The San Francisco 49ers vs. Seattle Seahawks game is at 8:00 PM ET on Saturday, January 17th.

Where is the San Francisco 49ers vs. Seattle Seahawks Game Being Played?

This game will be played at Lumen Field in Seattle, WA.

How Can I Watch Seattle vs. San Francisco?

You can watch Seattle Seahawks vs. San Francisco 49ers on FOX.

Can the 49ers Beat the Seahawks?

Yes, these teams split the season series, but it'll take be a tough task for San Fran as they are not near full strength for this one.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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