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Last Updated Jan 14 2026, 1:20 PM

NFL Divisional Round: Buffalo Bills vs. Denver Broncos Prediction, Odds, Preview

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read

Featured Image Credit: Tina MacIntyre via Imagn Images

BUF @ DEN Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Buffalo Bills 391 Bills
-1.5 +102 +0.5 -130 + +0.5 -120 + +0.5 -122 + -1.5 +118 + +1.5 -135 + +0.5 -120 + -0.5 +110 + +1.5 -143 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 -0.5 +110 + -0.5 even + -0.5 +102 + +1.5 -141 + -1.5 +115 + -0.5 even + +0.5 -130 + -1.5 +116 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o22.5 -115 + o22.5 -118 + o22.5 -112 + o22.5 -115 + o23.5 +110 + o22.5 -120 + o22.5 -120 + o22.5 -132 + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u22.5 -105 + u22.5 -102 + u22.5 -108 + u22.5 -106 + u23.5 -130 + u22.5 even + u22.5 even + u22.5 -103 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -105 + -105 + -108 + -104 + -104 + N/A -105 + -108 + even  
Denver Broncos 392 Broncos
-108 -115 + -115 + -112 + -117 + -118 + N/A -115 + -115 + -120  
Buffalo Bills 391 Bills
-1.5 +102 +0.5 -165 + +0.5 -165 + +0.5 -166 + N/A +1.5 -170 + +0.5 -160 + +1.5 -170 + +1.5 -180 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 -0.5 +140 + -0.5 +130 + -0.5 +140 + N/A -1.5 +140 + -0.5 +135 + -1.5 +140 + -1.5 +143 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o9.5 -110 + o9.5 -105 + o8.5 -110 + N/A o8.5 -112 + o8.5 -110 + o8.5 -115 + o9.5 -113 + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u9.5 -110 + u9.5 -120 + u8.5 -110 + N/A u8.5 -108 + u8.5 -110 + u8.5 -115 + u9.5 -110 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -105 + -102 + -105 + N/A -100 + N/A -110 + -108 + even  
Denver Broncos 392 Broncos
-108 -115 + -120 + -115 + N/A -122 + N/A -120 + -115 + -120  
Buffalo Bills 391 Bills
-1.5 +102 +0.5 -120 + N/A +1.5 -140 + N/A +1.5 -145 + N/A N/A +1.5 -143 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 -0.5 even + N/A -1.5 +110 + N/A -1.5 +125 + N/A N/A -1.5 +116 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o22.5 -115 + N/A o23.5 -105 + N/A o22.5 -105 + o23.5 -105 + N/A o22.5 -115 + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u22.5 -105 + N/A u23.5 -115 + N/A u22.5 -115 + u23.5 -125 + N/A u22.5 -108 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -105 + N/A -110 + N/A -108 + N/A N/A -108 + even  
Denver Broncos 392 Broncos
-108 -115 + N/A -120 + N/A -108 + N/A N/A -115 + -120  
Buffalo Bills 391 Bills
-1.5 +102 N/A N/A +0.5 -145 + N/A +1.5 -160 + +0.5 -140 + N/A +1.5 -162 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 N/A N/A -0.5 +114 + N/A -1.5 +130 + -0.5 +110 + N/A -1.5 +130 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o13.5 even + N/A o13.5 even + N/A o13.5 -122 + o13.5 even + N/A o13.5 -110 + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u13.5 -120 + N/A u13.5 -130 + N/A u13.5 -100 + u13.5 -130 + N/A u13.5 -113 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -105 + N/A -115 + N/A -108 + N/A N/A -110 + even  
Denver Broncos 392 Broncos
-108 -115 + N/A -115 + N/A -112 + N/A N/A -113 + -120  
Buffalo Bills 391 Bills
-1.5 +102 N/A N/A +0.5 -160 + N/A -1.5 +152 + +0.5 -165 + N/A +1.5 -180 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 N/A N/A -0.5 +124 + N/A +1.5 -188 + -0.5 +125 + N/A -1.5 +143 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o9.5 -115 + N/A o9.5 -130 + N/A o8.5 -110 + o9.5 -120 + N/A o9.5 -109 + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u9.5 -105 + N/A u9.5 even + N/A u8.5 -110 + u9.5 -110 + N/A u9.5 -114 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -110 + N/A -110 + N/A -110 + N/A N/A -108 + even  
Denver Broncos 392 Broncos
-108 -110 + N/A -120 + N/A -110 + N/A N/A -115 + -120  
Buffalo Bills 391 Bills
-1.5 +102 +0.5 -140 + N/A +0.5 -140 + N/A -1.5 +136 + +0.5 -140 + N/A +1.5 -165 + +1.5 -112  
Denver Broncos 392 Broncos
+1.5 -122 -0.5 +120 + N/A -0.5 +110 + N/A +1.5 -166 + -0.5 +110 + N/A -1.5 +133 + -1.5 -108  
Buffalo Bills 391 Bills
o46.5 -110 o13.5 +105 + N/A o13.5 -110 + N/A o12.5 -124 + o13.5 -105 + N/A o13.5 even + o45.5 -112  
Denver Broncos 392 Broncos
u46.5 -110 u13.5 -125 + N/A u13.5 -120 + N/A u12.5 +102 + u13.5 -125 + N/A u13.5 -124 + u45.5 -108  
Buffalo Bills 391 Bills
-112 -110 + N/A -115 + N/A -110 + N/A N/A -109 + even  
Denver Broncos 392 Broncos
-108 -110 + N/A -115 + N/A -110 + N/A N/A -114 + -120  

The Bills will take on the Broncos in this week's NFL action. Kickoff is set for 4:30 p.m. EST at Empower Field at Mile High in Denver, Colo. The game will be broadcast live on CBS. Here's everything you need to know about Bills vs. Broncos odds, the latest NFL spreads, NFL over/unders and more.

The Broncos opened as a -1 point favorite over Bills. The total is set at over/under 46.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Buffalo Bills vs. Denver Broncos Prediction

Been waiting all year to fade the Broncos in the playoffs and the time has come. I don’t trust the Broncos. I think they are one of the most overrated 1-seeds in my lifetime. Their defense is great but the offense is league average at best.

Denver failed to eclipse 20 points in any of its final three games. Their final 2 games were against the Chiefs' and Chargers' backups and they still struggled to score. Morevoer, the Jaguars held them to 20 on their home field. The defense is great – but their one weakness is a strength of Buffalo’s - Denver ranks only 27th in DVOA against passes to slot receivers, which bodes great for Khalil Shakir.

If you want to go next level – Josh Allen has done quite well versus man coverage – that’s primarily the way Denver likes to play with a corner as dynamic as Patrick Surtain II.

If you turn your back to Josh Allen, he’s going to run, and that could help neutralize the Broncos' pass rush. The Broncos have not committed to the run the way they probably should, especially in this matchup. 63% pass rate in neutral situations. That’s not how you want to play Buffalo. Allen is in hero ball mode and I think he goes out and gets a win – continuing his road to the Super Bowl.

Buffalo Bills vs. Denver Broncos Prediction: Bills -1.5 (-104)

(Pick from Brandon Kravitz)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the Buffalo Bills vs. Denver Broncos Game?

The Buffalo Bills vs. Denver Broncos game is at 8:00 PM ET on Saturday, January 17th.

Where is the Buffalo Bills vs. Denver Broncos Game Being Played?

This game will be played at Empower Field at Mile High in Denver, Colorado.

How Can I Watch Denver vs. Buffalo?

You can watch the Buffalo Bills vs. Denver Broncos on CBS.

Can the Broncos Beat the Bills?

Yes, some sportsbooks have this priced a pick 'em. This is a rare instance where the 1-seed is an underdog in a divisional matchup.

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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