NFL: New England Patriots vs. Buffalo Bills: Prediction, Odds, Preview
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BUF @ NE Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | -1 -105 | -1 -105 | -1.5 even | -1 -109 | -1.5 -108 | -1 -110 | -0.5 -115 | -1 -109 | -1.5 even | |
| | +4.5 -110 | +1 -115 | +1 -115 | +1.5 -120 | +1 -110 | +1.5 -112 | +1 -110 | +0.5 -105 | +1 -114 | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | o49.5 -110 | o49.5 -110 | o50.5 -110 | o49.5 -114 | o49.5 -110 | o49.5 -115 | o49.5 -110 | o49 -110 | o50.5 -110 | |
| | u46.5 -110 | u49.5 -110 | u49.5 -110 | u50.5 -110 | u49.5 -106 | u49.5 -110 | u49.5 -105 | u49.5 -110 | u49 -112 | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | -110 | -115 | -115 | -115 | -122 | -120 | -120 | -117 | -115 | |
| | +164 | -110 | -105 | -105 | -104 | +104 | even | even | -107 | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | -1.5 +114 | -1.5 +115 | N/A | -0.5 +105 | -1.5 +118 | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | +1.5 -137 | +1.5 -135 | N/A | +0.5 -125 | +1.5 -148 | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | o24.5 -105 | o24.5 -100 | N/A | o24.5 even | o24.5 -103 | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | u24.5 -115 | u24.5 -120 | N/A | u24.5 -120 | u24.5 -121 | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | -114 | -118 | N/A | -110 | -114 | -115 | |
| | +164 | N/A | N/A | N/A | -106 | -104 | N/A | -110 | -109 | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | N/A | -1.5 +120 | N/A | N/A | -1.5 +117 | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | N/A | +1.5 -140 | N/A | N/A | +1.5 -148 | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | N/A | o23.5 -115 | N/A | N/A | o23.5 -113 | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | N/A | u23.5 -105 | N/A | N/A | u23.5 -110 | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | N/A | -116 | N/A | N/A | -115 | -115 | |
| | +164 | N/A | N/A | N/A | N/A | -100 | N/A | N/A | -108 | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | N/A | -1.5 +142 | N/A | -0.5 +140 | +1.5 -190 | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | N/A | +1.5 -174 | N/A | +0.5 -170 | -1.5 +150 | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | N/A | o9.5 -134 | N/A | o8.5 -150 | o9.5 -130 | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | N/A | u9.5 +110 | N/A | u8.5 +110 | u9.5 +105 | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | N/A | -115 | N/A | -115 | -114 | -115 | |
| | +164 | N/A | N/A | N/A | N/A | -105 | N/A | -115 | -109 | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | N/A | -1.5 +126 | N/A | N/A | N/A | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | N/A | +1.5 -152 | N/A | N/A | N/A | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | N/A | o14.5 -112 | N/A | N/A | N/A | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | N/A | u14.5 -108 | N/A | N/A | N/A | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | N/A | -114 | N/A | N/A | N/A | -115 | |
| | +164 | N/A | N/A | N/A | N/A | -105 | N/A | N/A | N/A | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | N/A | -1.5 +142 | N/A | N/A | N/A | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | N/A | +1.5 -174 | N/A | N/A | N/A | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | N/A | o9.5 -124 | N/A | N/A | N/A | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | N/A | u9.5 +102 | N/A | N/A | N/A | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | N/A | -115 | N/A | N/A | N/A | -115 | |
| | +164 | N/A | N/A | N/A | N/A | -105 | N/A | N/A | N/A | -105 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | | | | | | | | | | ||
| | -4.5 -110 | N/A | N/A | N/A | N/A | -1.5 +134 | N/A | N/A | N/A | -1.5 even | |
| | +4.5 -110 | N/A | N/A | N/A | N/A | +1.5 -162 | N/A | N/A | N/A | +1.5 -120 | |
| Open | | | | | | | | | | ||
| | o46.5 -110 | N/A | N/A | N/A | N/A | o13.5 -116 | N/A | N/A | N/A | o50.5 -110 | |
| | u46.5 -110 | N/A | N/A | N/A | N/A | u13.5 -106 | N/A | N/A | N/A | u50.5 -110 | |
| Open | | | | | | | | | | ||
| | -198 | N/A | N/A | N/A | N/A | -115 | N/A | N/A | N/A | -115 | |
| | +164 | N/A | N/A | N/A | N/A | -105 | N/A | N/A | N/A | -105 | |
The Bills will take on the Patriots in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Gillette Stadium in Foxborough, Mass. The game will be broadcast live on CBS. Here's everything you need to know about Bills vs. Patriots odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -1 point favorite over Patriots. The total is set at over/under 49.5 total points scored by both teams combined.
Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!
Updated on 12/8/25

New England Patriots vs. Buffalo Bills Prediction
The Patriots come in at 4th in Action Network's luck rankings, and the Bills come in at 11th. This indicates that some scoring regression may be inbound for this matchup. These are also two good defenses. The Patriots rank 9th in EPA/play allowed, while the Bills rank 16th.
Both units are strong defending against the pass, as the Bills and Patriots are both top 10 in EPA/pass attempt allowed. I expect a low-scoring affair in this AFC East matchup.

New England Patriots vs. Buffalo Bills Prediction: Buffalo Bills @ New England Patriots u50.5 (-110)
(Pick from Dylan Wilkerson)
Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!
What Time is the New England Patriots vs. Buffalo Bills Game?
The New England Patriots vs. Buffalo Bills game is at 1:00 PM ET on Sunday, December 14th.
Where is the New England Patriots vs. Buffalo Bills Game Being Played?
This game will be played at Gillette Stadium in Foxborough, Mass.
How Can I Watch New England Patriots vs. Buffalo Bills?
You can watch New England Patriots vs. Buffalo Bills on CBS.
Can the Patriots Beat the Bills?
Of course! this game is close, anything can happen in the NFL!
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