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Featured Last Updated Dec 8 2025, 2:06 PM

NFL: New England Patriots vs. Buffalo Bills: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: New England Patriots vs. Buffalo Bills: Prediction, Odds, Preview

Featured Image Credit: Joseph Maiorana-Imagn Images

BUF @ NE Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A -1.5 +114 + -1.5 +115 + N/A -0.5 +105 + -1.5 +118 + -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A +1.5 -137 + +1.5 -135 + N/A +0.5 -125 + +1.5 -148 + +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A o24.5 -105 + o24.5 -100 + N/A o24.5 even + o24.5 -103 + o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A u24.5 -115 + u24.5 -120 + N/A u24.5 -120 + u24.5 -121 + u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A -114 + -118 + N/A -110 + -114 + -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A -106 + -104 + N/A -110 + -109 + -105  
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A N/A -1.5 +120 + N/A N/A -1.5 +117 -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A N/A +1.5 -140 + N/A N/A +1.5 -148 +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A N/A o23.5 -115 + N/A N/A o23.5 -113 o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A N/A u23.5 -105 + N/A N/A u23.5 -110 u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A N/A -116 + N/A N/A -115 + -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A N/A -100 + N/A N/A -108 + -105  
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A N/A -1.5 +142 + N/A -0.5 +140 + +1.5 -190 + -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A N/A +1.5 -174 + N/A +0.5 -170 + -1.5 +150 + +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A N/A o9.5 -134 + N/A o8.5 -150 + o9.5 -130 + o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A N/A u9.5 +110 + N/A u8.5 +110 + u9.5 +105 + u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A N/A -115 + N/A -115 + -114 + -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A N/A -105 + N/A -115 + -109 + -105  
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A N/A -1.5 +126 + N/A N/A N/A -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A N/A +1.5 -152 + N/A N/A N/A +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A N/A o14.5 -112 + N/A N/A N/A o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A N/A u14.5 -108 + N/A N/A N/A u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A N/A -114 + N/A N/A N/A -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A N/A -105 + N/A N/A N/A -105  
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A N/A -1.5 +142 + N/A N/A N/A -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A N/A +1.5 -174 + N/A N/A N/A +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A N/A o9.5 -124 + N/A N/A N/A o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A N/A u9.5 +102 + N/A N/A N/A u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A N/A -115 + N/A N/A N/A -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A N/A -105 + N/A N/A N/A -105  
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A N/A N/A -1.5 +134 + N/A N/A N/A -1.5 even  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A N/A N/A +1.5 -162 + N/A N/A N/A +1.5 -120  
Buffalo Bills 463 Bills
o46.5 -110 N/A N/A N/A N/A o13.5 -116 + N/A N/A N/A o50.5 -110  
New England Patriots 464 Patriots
u46.5 -110 N/A N/A N/A N/A u13.5 -106 + N/A N/A N/A u50.5 -110  
Buffalo Bills 463 Bills
-198 N/A N/A N/A N/A -115 + N/A N/A N/A -115  
New England Patriots 464 Patriots
+164 N/A N/A N/A N/A -105 + N/A N/A N/A -105  

The Bills will take on the Patriots in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Gillette Stadium in Foxborough, Mass. The game will be broadcast live on CBS. Here's everything you need to know about Bills vs. Patriots odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -1 point favorite over Patriots. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 12/8/25

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New England Patriots vs. Buffalo Bills Prediction

The Patriots come in at 4th in Action Network's luck rankings, and the Bills come in at 11th. This indicates that some scoring regression may be inbound for this matchup. These are also two good defenses. The Patriots rank 9th in EPA/play allowed, while the Bills rank 16th.

Both units are strong defending against the pass, as the Bills and Patriots are both top 10 in EPA/pass attempt allowed. I expect a low-scoring affair in this AFC East matchup.

New England Patriots vs. Buffalo Bills Prediction: Buffalo Bills @ New England Patriots u50.5 (-110)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the New England Patriots vs. Buffalo Bills Game?

The New England Patriots vs. Buffalo Bills game is at 1:00 PM ET on Sunday, December 14th.

Where is the New England Patriots vs. Buffalo Bills Game Being Played?

This game will be played at Gillette Stadium in Foxborough, Mass.

How Can I Watch New England Patriots vs. Buffalo Bills?

You can watch New England Patriots vs. Buffalo Bills on CBS.

Can the Patriots Beat the Bills?

Of course! this game is close, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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