Sign Up Subscribe
Featured

NFL: Philadelphia Eagles vs. Buffalo Bills: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Philadelphia Eagles vs. Buffalo Bills: Prediction, Odds, Preview

Featured Image Credit: Brian Fluharty-Imagn Images

PHI @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 +2.5 even +2.5 -102 +1.5 -110 +2.5 +108 +2.5 -110 +2.5 -110 +3.5 -125 +1.5 -110 +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 -2.5 -120 -2.5 -118 -1.5 -110 -2.5 -127 -2.5 -110 -2.5 -110 -3.5 even -1.5 -115 -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o21.5 -115 o21.5 -118 o22.5 -108 o22.5 -108 o23.5 +110 o22.5 -110 o20.5 -125 o22.5 -122 o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u21.5 -105 u21.5 -110 u22.5 -112 u22.5 -113 u23.5 -130 u22.5 -110 u20.5 -115 u22.5 -103 u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +145 +140 +124 +140 +130 N/A +150 +123 +142  
Buffalo Bills 428 Bills
-122 -170 -165 -148 -170 -160 N/A -220 -155 -170  
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 +0.5 -130 +0.5 -135 +0.5 -130 N/A +1.5 -150 +0.5 -135 +1.5 -115 +1.5 -162 +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 -0.5 +110 -0.5 +105 -0.5 +110 N/A -1.5 +124 -0.5 +115 -1.5 -115 -1.5 +128 -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o7.5 -110 o7.5 -120 o8.5 -110 N/A o7.5 -108 o7.5 -110 o8.5 +125 o9.5 -109 o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u7.5 -110 u7.5 -105 u8.5 -110 N/A u7.5 -110 u7.5 -110 u8.5 -190 u9.5 -114 u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +125 +120 +124 N/A +118 N/A +170 +107 +142  
Buffalo Bills 428 Bills
-122 -150 -155 -148 N/A -140 N/A -250 -134 -170  
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 +1.5 -110 N/A +2.5 -115 N/A +1.5 -115 N/A +1.5 -115 +1.5 -120 +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 -1.5 -110 N/A -2.5 -115 N/A -1.5 -105 N/A -1.5 -115 -1.5 -105 -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o22.5 -110 N/A o22.5 -115 N/A o21.5 -105 o22.5 -120 o22.5 -125 o21.5 -114 o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u22.5 -110 N/A u22.5 -105 N/A u21.5 -115 u22.5 -110 u22.5 -115 u21.5 -109 u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +115 N/A +135 N/A +122 N/A +115 +115 +142  
Buffalo Bills 428 Bills
-122 -135 N/A -175 N/A -144 N/A -160 -143 -170  
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A +1.5 -120 N/A +1.5 -126 +0.5 -120 +1.5 -125 N/A +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A -1.5 -110 N/A -1.5 +102 -0.5 -110 -1.5 even N/A -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o13.5 -105 N/A o13.5 -105 N/A o9.5 -116 o13.5 even o12.5 -165 N/A o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u13.5 -115 N/A u13.5 -125 N/A u9.5 -116 u13.5 -130 u12.5 +110 N/A u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +130 N/A +124 N/A +122 N/A +110 N/A +142  
Buffalo Bills 428 Bills
-122 -155 N/A -160 N/A -150 N/A -170 N/A -170  
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A +0.5 -154 N/A +1.5 -152 +0.5 -140 +1.5 -125 N/A +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A -0.5 +120 N/A -1.5 +126 -0.5 +110 -1.5 -105 N/A -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o9.5 -115 N/A o9.5 -125 N/A o2.5 -118 o9.5 -115 o8.5 -145 N/A o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u9.5 -105 N/A u9.5 -105 N/A u2.5 -112 u9.5 -115 u8.5 even N/A u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +120 N/A even N/A +114 N/A +140 N/A +142  
Buffalo Bills 428 Bills
-122 -140 N/A -130 N/A -140 N/A -200 N/A -170  
Final
Philadelphia Eagles 427 Eagles
+1.5 -110 +0.5 -130 N/A +0.5 -135 N/A +1.5 -146 N/A -0.5 +120 N/A +3.5 -118  
Buffalo Bills 428 Bills
-1.5 -110 -0.5 +110 N/A -0.5 +105 N/A -1.5 +122 N/A +0.5 -160 N/A -3.5 -102  
Final
Philadelphia Eagles 427 Eagles
o46.5 -110 o13 -110 N/A o12.5 -130 N/A o12.5 -128 o13.5 even o12.5 -145 N/A o45.5 -105  
Buffalo Bills 428 Bills
u46.5 -110 u13 -110 N/A u12.5 even N/A u12.5 +104 u13.5 -130 u12.5 even N/A u45.5 -115  
Final
Philadelphia Eagles 427 Eagles
+102 +105 N/A even N/A +106 N/A -115 N/A +142  
Buffalo Bills 428 Bills
-122 -125 N/A -130 N/A -132 N/A -120 N/A -170  

The Eagles will take on the Bills in this week's NFL action. Kickoff is set for 4:25 p.m. EST at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on FOX. Here's everything you need to know about Eagles vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -2.5 point favorite over Eagles. The total is set at over/under 45 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 2/7/26

bet365
Bet $5, Get $200 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $200
Deposit Required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers Only. T&Cs, time limits, and exclusions apply. 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, MO, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $200 in Bonus Bets at bet365. Minimum odds -500 of greater.

Philadelphia Eagles vs. Buffalo Bills Prediction

The Bills have a clear offensive advantage in this matchup. They rank 4th in dropback EPA/play and 2nd in rush EPA/play. James Cook has proven that he can be explosive on any given play, as he leads the league in rushes over 10 yards (tied with De'Von Achane with 36).

These two teams have equal pass defenses, but the Bills' rush offense is poised to control this game. The Bills have an advantage on 3rd down, ranking 3rd in 3rd-down EPA/play.

The Bills should take care of the Eagles in Week 17.

Philadelphia Eagles vs. Buffalo Bills Prediction: Buffalo Bills Moneyline (-134)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

Google Preferred Source

What Time is the Philadelphia Eagles vs. Buffalo Bills Game?

The Philadelphia Eagles vs. Buffalo Bills game is at 4:25 PM ET on Sunday, December 28th.

Where is the Philadelphia Eagles vs. Buffalo Bills Game Being Played?

This game will be played at Orchard Park, N.Y.

How Can I Watch Philadelphia Eagles vs. Buffalo Bills?

You can watch Philadelphia Eagles vs. Buffalo Bills on FOX.

Can the Bills Beat the Eagles?

Of course! The Buffalo Bills are slight favorites, so the oddsmakers think Buffalo will win but anything can happen in the NFL.

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•