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Featured Last Updated Dec 22 2025, 12:02 PM

NFL: Philadelphia Eagles vs. Buffalo Bills: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Philadelphia Eagles vs. Buffalo Bills: Prediction, Odds, Preview

Featured Image Credit: Brian Fluharty-Imagn Images

PHI @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A +0.5 -115 + +1.5 -130 + +1.5 -120 + N/A +1.5 -120 + N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A -0.5 -105 + -1.5 +108 + -1.5 -100 + N/A -1.5 even + N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A o21.5 -115 + o21.5 -127 + o22.5 -110 + N/A o22.5 -110 + N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A u21.5 -105 + u21.5 +105 + u22.5 -110 + N/A u22.5 -110 + N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A +102 + +107 + +110 + N/A +105 + N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A -122 + -129 + -136 + N/A -125 + N/A -135  
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A +0.5 -162 + N/A +1.5 -166 + N/A +1.5 -170 + N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A -0.5 +136 + N/A -1.5 +140 + N/A -1.5 +140 + N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A o7.5 even + N/A o7.5 -104 + N/A o8.5 -105 + N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A u7.5 -120 + N/A u7.5 -118 + N/A u8.5 -125 + N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A even + N/A +102 + N/A -105 + N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A -120 + N/A -124 + N/A -125 + N/A -135  
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A N/A N/A +1.5 -135 + N/A N/A N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A N/A N/A -1.5 +115 + N/A N/A N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A N/A N/A o21.5 -100 + N/A N/A N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A N/A N/A u21.5 -120 + N/A N/A N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A N/A N/A +104 + N/A N/A N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A N/A N/A -124 + N/A N/A N/A -135  
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A N/A N/A +1.5 -142 + N/A N/A N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A N/A N/A -1.5 +114 + N/A N/A N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A N/A N/A o13.5 -110 + N/A N/A N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A N/A N/A u13.5 -110 + N/A N/A N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A N/A N/A +104 + N/A N/A N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A N/A N/A -128 + N/A N/A N/A -135  
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A N/A N/A +1.5 -172 + N/A N/A N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A N/A N/A -1.5 +138 + N/A N/A N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A N/A N/A o7.5 -106 + N/A N/A N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A N/A N/A u7.5 -116 + N/A N/A N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A N/A N/A -100 + N/A N/A N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A N/A N/A -122 + N/A N/A N/A -135  
Philadelphia Eagles 427 Eagles
+1.5 -110 N/A N/A N/A N/A +1.5 -162 + N/A N/A N/A +2.5 -112  
Buffalo Bills 428 Bills
-1.5 -110 N/A N/A N/A N/A -1.5 +132 + N/A N/A N/A -2.5 -108  
Philadelphia Eagles 427 Eagles
o46.5 -110 N/A N/A N/A N/A o12.5 -110 + N/A N/A N/A o43.5 -115  
Buffalo Bills 428 Bills
u46.5 -110 N/A N/A N/A N/A u12.5 -110 + N/A N/A N/A u43.5 -105  
Philadelphia Eagles 427 Eagles
+102 N/A N/A N/A N/A -104 + N/A N/A N/A +114  
Buffalo Bills 428 Bills
-122 N/A N/A N/A N/A -118 + N/A N/A N/A -135  

The Eagles will take on the Bills in this week's NFL action. Kickoff is set for 4:25 p.m. EST at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on FOX. Here's everything you need to know about Eagles vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -2.5 point favorite over Eagles. The total is set at over/under 45 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 12/22/25

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Philadelphia Eagles vs. Buffalo Bills Prediction

The Bills have a clear offensive advantage in this matchup. They rank 4th in dropback EPA/play and 2nd in rush EPA/play. James Cook has proven that he can be explosive on any given play, as he leads the league in rushes over 10 yards (tied with De'Von Achane with 36).

These two teams have equal pass defenses, but the Bills' rush offense is poised to control this game. The Bills have an advantage on 3rd down, ranking 3rd in 3rd-down EPA/play.

The Bills should take care of the Eagles in Week 17.

Philadelphia Eagles vs. Buffalo Bills Prediction: Buffalo Bills Moneyline (-134)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the Philadelphia Eagles vs. Buffalo Bills Game?

The Philadelphia Eagles vs. Buffalo Bills game is at 4:25 PM ET on Sunday, December 28th.

Where is the Philadelphia Eagles vs. Buffalo Bills Game Being Played?

This game will be played at Orchard Park, N.Y.

How Can I Watch Philadelphia Eagles vs. Buffalo Bills?

You can watch Philadelphia Eagles vs. Buffalo Bills on FOX.

Can the Bills Beat the Eagles?

Of course! The Buffalo Bills are slight favorites, so the oddsmakers think Buffalo will win but anything can happen in the NFL.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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