Sign Up Subscribe
Featured Last Updated Nov 25 2025, 3:03 PM

NFL: Houston Texans vs. Indianapolis Colts: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Houston Texans vs. Indianapolis Colts: Prediction, Odds, Preview

Featured Image Credit: Troy Taormina-Imagn Images

HOU @ IND Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Houston Texans 461 Texans
-1.5 -110 +2.5 -105 + +2.5 even + +2.5 -102 + +2.5 -104 + +3.5 -120 + +2.5 +105 + +1.5 +105 + +2.5 +102 + +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 -2.5 -115 + -2.5 -120 + -2.5 -118 + -2.5 -117 + -3.5 -100 + -2.5 -125 + -1.5 -125 + -2.5 -125 + -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o21.5 -115 + o22.5 -110 + o22.5 -105 + o22.5 -110 + o23.5 +110 + o22.5 -115 + o22.5 -110 + o22.5 -125 + o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u21.5 -105 + u22.5 -110 + u22.5 -115 + u22.5 -110 + u23.5 -125 + u22.5 -105 + u22.5 -110 + u22.5 +102 + u44.5 -105  
Houston Texans 461 Texans
-122 +140 + +145 + +140 + +148 + +158 + N/A +145 + +148 + +180  
Indianapolis Colts 462 Colts
+102 -170 + -180 + -170 + -182 + -198 + N/A -175 + -186 + -225  
Houston Texans 461 Texans
-1.5 -110 +0.5 -130 + +0.5 -130 + +0.5 -135 + N/A +1.5 -122 + +0.5 -120 + +1.5 -130 + +1.5 -127 + +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 -0.5 +110 + -0.5 even + -0.5 +114 + N/A -1.5 -100 + -0.5 even + -1.5 +110 + -1.5 +102 + -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o7.5 even + o7.5 even + o7.5 +102 + N/A o9.5 -106 + o7.5 -110 + o8.5 -105 + o9.5 -109 + o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u7.5 -120 + u7.5 -130 + u7.5 -120 + N/A u9.5 -116 + u7.5 -110 + u8.5 -125 + u9.5 -114 + u44.5 -105  
Houston Texans 461 Texans
-122 +125 + +130 + +124 + N/A +146 + N/A +130 + +140 + +180  
Indianapolis Colts 462 Colts
+102 -150 + -165 + -148 + N/A -184 + N/A -170 + -177 + -225  
Houston Texans 461 Texans
-1.5 -110 N/A N/A +1.5 -120 + N/A +1.5 -114 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 N/A N/A -1.5 -110 + N/A -1.5 -104 + N/A N/A N/A -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o13 -110 + N/A o13.5 even + N/A o13.5 -110 + N/A N/A N/A o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u13 -110 + N/A u13.5 -130 + N/A u13.5 -110 + N/A N/A N/A u44.5 -105  
Houston Texans 461 Texans
-122 +145 + N/A +130 + N/A +132 + N/A N/A N/A +180  
Indianapolis Colts 462 Colts
+102 -170 + N/A -166 + N/A -162 + N/A N/A N/A -225  
Houston Texans 461 Texans
-1.5 -110 N/A N/A +0.5 -135 + N/A +1.5 -174 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 N/A N/A -0.5 +105 + N/A -1.5 +142 + N/A N/A N/A -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o9.5 -115 + N/A o9.5 -120 + N/A o8.5 -116 + N/A N/A N/A o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u9.5 -105 + N/A u9.5 -110 + N/A u8.5 -106 + N/A N/A N/A u44.5 -105  
Houston Texans 461 Texans
-122 +115 + N/A +114 + N/A -102 + N/A N/A N/A +180  
Indianapolis Colts 462 Colts
+102 -135 + N/A -145 + N/A -120 + N/A N/A N/A -225  
Houston Texans 461 Texans
-1.5 -110 +0.5 -120 + N/A +0.5 -110 + N/A +1.5 -136 + N/A N/A N/A +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 -0.5 even + N/A -0.5 -120 + N/A -1.5 +112 + N/A N/A N/A -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o13 -110 + N/A o13.5 even + N/A o12.5 -108 + N/A N/A N/A o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u13 -110 + N/A u13.5 -130 + N/A u12.5 -112 + N/A N/A N/A u44.5 -105  
Houston Texans 461 Texans
-122 +115 + N/A +124 + N/A +116 + N/A N/A N/A +180  
Indianapolis Colts 462 Colts
+102 -135 + N/A -160 + N/A -142 + N/A N/A N/A -225  
Houston Texans 461 Texans
-1.5 -110 +2.5 -110 + N/A N/A N/A +1.5 -120 + N/A N/A +1.5 -120 + +4.5 -115  
Indianapolis Colts 462 Colts
+1.5 -110 -2.5 -110 + N/A N/A N/A -1.5 -100 + N/A N/A -1.5 -105 + -4.5 -105  
Houston Texans 461 Texans
o44.5 -110 o22.5 -110 + N/A N/A N/A o21.5 -100 + N/A N/A o21.5 -105 + o44.5 -115  
Indianapolis Colts 462 Colts
u44.5 -110 u22.5 -110 + N/A N/A N/A u21.5 -120 + N/A N/A u21.5 -120 + u44.5 -105  
Houston Texans 461 Texans
-122 +125 + N/A N/A N/A +116 + N/A N/A +115 + +180  
Indianapolis Colts 462 Colts
+102 -150 + N/A N/A N/A -138 + N/A N/A -141 + -225  

The Texans will take on the Colts in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Lucas Oil Stadium in Indianapolis, Ind. The game will be broadcast live on CBS. Here's everything you need to know about Texans vs. Colts odds, the latest NFL spreads, NFL over/unders and more.

The Colts opened as a -4.5 point favorite over Texans. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 11/26/25

bet365
Bet $5, Get $150 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $150
Deposit Required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers Only. T&Cs, time limits, and exclusions apply. 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $150 in Bonus Bets at bet365. Minimum odds -500 of greater.

Houston Texans vs. Indianapolis Colts Prediction

C.J. Stroud is expected to be back to complement this top-tier Texans defense. The Texans are amongst the Rams, Bengals, and Seahawks when it comes to the best defenses in the NFL, and they have arguably the best pass defense. The Texans have allowed the 2nd-lowest EPA/play and are 1st in dropback EPA allowed (-0.127).

There is a difference in the schedules these two teams have faced as well. PFF has the Colts schedule ranked 27th, whereas the Texans strength of schedule is ranked 13th. The Texans should keep this one close in Stroud's return.

Houston Texans vs. Indianapolis Colts Prediction: Houston Texans +4.5 (-105)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

Google Preferred Source

What Time is the Houston Texans vs. Indianapolis Colts Game?

The Houston Texans vs. Indianapolis Colts game is at 1:00 PM ET on Sunday, November 30th.

Where is the Houston Texans vs. Indianapolis Colts Game Being Played?

This game will be played at Lucas Oil Stadium in Indianapolis, Ind.

How Can I Watch Houston Texans vs. Indianapolis Colts?

You can watch Houston Texans vs. Indianapolis Colts on CBS.

Can the Texans Beat the Colts?

Of course! The Texans are a 4.5 point underdog, anything can happen in the NFL!

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•