NFL Odds Week 2: 49ers vs Rams Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

NFL odds for Week 2 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The 49ers and Rams meet at SoFi Stadium in Inglewood, California on Sunday, September 17 at 4:05 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for the Week 2 game between the 49ers and Rams: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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San Francisco 49ers vs Los Angeles Rams Odds

  • Opening point spread: 49ers -6.5
  • Opening moneyline: 49ers -400/Rams +300
  • Opening total: Over/Under 42 points scored
  • Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 6:30 P.M. ET FRIDAY: After opening at Niners -6.5, BetMGM has bounced around this week. San Fran climbed to -8.5 by Monday afternoon, then receded to -7.5 Thursday afternoon.

Early spread bettors are leaning toward the Rams, at 62% of ticket/54% of money. Further, moneyline tickets are 2/1 and moneyline cash 3/1 on Los Angeles, which is currently +280.

UPDATE 11 P.M. ET SUNDAY: San Francisco (1-0 SU and ATS) closed as a 1.5-point favorite at Pittsburgh. It was never close, as the Niners bolted to a 20-0 lead en route to a 30-7 victory.

Meanwhile, Los Angeles (1-0 SU and ATS) notched one of the more surprising Week 1 results. The Rams were 4.5-point 'dogs at Seattle and trailed 13-7 at halftime. But L.A. scored the final 23 points of the game, winning 30-13.

Neither the line nor total moved tonight in The SuperBook's NFL odds Week 2 market.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 2 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs Rams Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

The Niners have dominated this division rivalry, winning eight of the last nine, and Kyle Shanahan is 10-3 ATS (77%) lifetime against Sean McVay. The 49ers are now 7-0 in regular season Brock Purdy games, with five of those wins by at least 16 points. Purdy has thrown at least two touchdowns in all seven games.

As good as the 49ers are, the Rams have the best player on both sides of the ball. If LA has any chance to hang, it has to be because Matt Stafford had a great game against these beatable corners. This number is way too low. Stafford has gone over 224.5 passing yards in 23 of 27 games with the Rams (85%), with three of the four misses his final three games last season before missing the second half to injury.

If you really believe in the Rams and think they can win this game, you have to go all-in and bet LA to win the NFC West (+1100). A win here puts them 2-0 with head-to-head wins against both competitors.

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Pick: Matt Stafford Over 224.5 Passing Yards (-115)

For more NFL Week 2 picks, check out Action Network's NFL Week 2: How to Bet Every Game & Every Team.

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  • Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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