NFL Odds Week 2: Raiders vs Bills Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

NFL odds for Week 2 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The Raiders and Bills meet at Highmark Stadium in Orchard Park, New York on Sunday, September 17 at 1:00 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for the Week 2 game between the Raiders and Bills: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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Las Vegas Raiders vs Buffalo Bills Odds

  • Opening point spread: Bills -10
  • Opening moneyline: Bills -450/Raiders +350
  • Opening total: Over/Under 47
  • Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 A.M. ET SUNDAY: The Bills are down to -7.5 this morning at BetMGM, after opening -9.5 and peaking at -10 early in the week. Buffalo is taking 57% of spread bets/67% of spread money.

The total opened at 47.5, spent most of the week at 47 and went to 46.5 Saturday. The Over is getting 55% of bets/58% of money.

UPDATE 6 P.M. ET FRIDAY: Buffalo initially went from -9.5 to -10 Monday at BetMGM, but the line dropped to -8 by late Thursday morning. The number quickly adjusted to Bills -8.5, where it remains now.

Interestingly, the Raiders are drawing 61% of early spread tickets/56% of early spread money. Las Vegas is also getting moneyline play, at 80% of tickets/75% of money, while moving from +350 to +310.

BetMGM's total opened 47.5, briefly touched 46.5 Tuesday and has been at 47 since then. Ticket count is 2/1 and money 5/1 on the Under.

UPDATE 10 P.M. ET SUNDAY: Las Vegas (1-0 SU and ATS) is on the road again in Week 2, but that suited the Raiders just fine in Week 1. The Silver-and-Black went to Denver as a 3-point pup and got a late touchdown to exit with a 17-16 victory.

Buffalo still has Week 1 work to do, opening on Monday night against Aaron Rodgers and the New York Jets. Still, The SuperBook opened the Bills as 10-point favorites against the Raiders in the NFL Week 2 odds market.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 2 Report containing spreads, lines, and trends for every NFL matchup.

Raiders vs Bills Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Buffalo is better than Las Vegas in every way — offense, defense, special teams, coaching, the works. Coming off last year's nightmare season, the Bills opened Week 1 by blowing a freebie against the Rodgers-less Jets.

The Raiders won a squeaker over the Broncos with a big game from WR Jakobi Meyers but will be without him and pass rusher Chandler Jones.

There's some value on this line after Josh Allen's Monday disaster, and the Bills typically win big when things go well. Don't overthink this — just lay points and be grateful to be under the -10 it was Sunday.

This is also a great teaser leg as long as it stays at -8.5 or below, getting Buffalo below the key number.

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Pick: Bills -8.5 (-105)

For more NFL Week 2 picks, check out Action Network's NFL Week 2: How to Bet Every Game & Every Team.

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  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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