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Featured Last Updated Sep 12 2025, 10:12 AM

Panthers vs. Cardinals Week 2 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
9 minute read
Panthers vs. Cardinals Week 2 Prediction: Odds, Best Bet

Carolina Panthers vs. Arizona Cardinals Odds, NFL Week 2

Image Credit: Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images

CAR @ ARI Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Carolina Panthers 269 Panthers
+4.5 -110 +3.5 -105 + +3.5 -102 + +3.5 -108 + +3.5 -104 + +3.5 -115 + +4.5 -130 + +3.5 -110 +3.5 -109 + +3.5 -109 +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 -3.5 -115 + -3.5 -118 + -3.5 -112 + -3.5 -115 + -3.5 -115 + -4.5 +110 + -3.5 -110 -3.5 -114 + -3.5 -114 -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o21.5 -115 + N/A o22.5 -108 + o22.5 -101 + N/A o22.5 -120 + o22.5 -130 o22.5 -117 + o22.5 -117 o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u21.5 -105 + N/A u22.5 -112 + u22.5 -118 + N/A u22.5 -100 + u22.5 +105 u22.5 -110 + u22.5 -110 u44.5 -115  
Carolina Panthers 269 Panthers
+164 +190 + N/A +180 + +185 + +180 + +198 + +175 +180 + +180 +235  
Arizona Cardinals 270 Cardinals
-198 -230 + N/A -218 + -225 + -250 + -250 + -210 -230 + -230 -290  
Carolina Panthers 269 Panthers
+4.5 -110 +0.5 -110 + +0.5 -115 + +0.5 -108 + +0.5 even + +0.5 -120 + +1.5 -118 + +1.5 -120 +1.5 -124 + +1.5 -124 +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 -0.5 -110 + -0.5 -110 + -0.5 -112 + -0.5 -130 + -0.5 -110 + -1.5 -104 + -1.5 -110 -1.5 even + -1.5 even -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o9.5 +110 + N/A o7.5 +102 + o8.5 -115 + o8.5 -115 + o7.5 -100 + o8.5 -120 o9.5 -112 + o9.5 -112 o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u9.5 -130 + N/A u7.5 -122 + u8.5 -115 + u8.5 -115 + u7.5 -122 + u8.5 -110 u9.5 -115 + u9.5 -115 u44.5 -115  
Carolina Panthers 269 Panthers
+164 +155 + N/A +164 + +170 + +150 + +158 + +145 +143 + +143 +235  
Arizona Cardinals 270 Cardinals
-198 -185 + N/A -198 + -210 + -200 + -196 + -190 -180 + -180 -290  
Carolina Panthers 269 Panthers
+4.5 -110 +3.5 -110 + N/A +3.5 -108 + +2.5 even + N/A +3.5 -120 + N/A +3.5 -117 + +3.5 -117 +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 -3.5 -110 + N/A -3.5 -112 + -2.5 -120 + N/A -3.5 -100 + N/A -3.5 -106 + -3.5 -106 -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o21.5 -105 + N/A o21.5 -112 + o22.5 -115 + N/A o21.5 -100 + N/A o20.5 -121 + o20.5 -121 o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u21.5 -115 + N/A u21.5 -108 + u22.5 -105 + N/A u21.5 -120 + N/A u20.5 -104 + u20.5 -104 u44.5 -115  
Carolina Panthers 269 Panthers
+164 +185 + N/A +185 + N/A N/A +168 + N/A +170 + +170 +235  
Arizona Cardinals 270 Cardinals
-198 -225 + N/A -225 + N/A N/A -200 + N/A -220 + -220 -290  
Carolina Panthers 269 Panthers
+4.5 -110 N/A N/A +2.5 -110 + +2.5 +105 + N/A +2.5 +102 + N/A N/A N/A +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 N/A N/A -2.5 -110 + -2.5 -125 + N/A -2.5 -124 + N/A N/A N/A -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o13.5 +105 + N/A o13.5 +105 + o13.5 even + N/A o13.5 -110 + N/A N/A N/A o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u13.5 -125 + N/A u13.5 -125 + u13.5 -125 + N/A u13.5 -110 + N/A N/A N/A u44.5 -115  
Carolina Panthers 269 Panthers
+164 +145 + N/A +142 + +162 + N/A +164 + N/A N/A N/A +235  
Arizona Cardinals 270 Cardinals
-198 -170 + N/A -170 + -195 + N/A -210 + N/A N/A N/A -290  
Carolina Panthers 269 Panthers
+4.5 -110 N/A N/A +0.5 -105 + +1.5 -125 + N/A +1.5 -126 + N/A N/A N/A +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 N/A N/A -0.5 -115 + -1.5 +105 + N/A -1.5 +104 + N/A N/A N/A -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o9.5 -110 + N/A o9.5 -115 + o8.5 -110 + N/A o8.5 -112 + N/A N/A N/A o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u9.5 -110 + N/A u9.5 -105 + u8.5 -110 + N/A u8.5 -108 + N/A N/A N/A u44.5 -115  
Carolina Panthers 269 Panthers
+164 +155 + N/A +154 + +143 + N/A +146 + N/A N/A N/A +235  
Arizona Cardinals 270 Cardinals
-198 -185 + N/A -185 + -170 + N/A -180 + N/A N/A N/A -290  
Carolina Panthers 269 Panthers
+4.5 -110 +0.5 +110 + N/A +2.5 -110 + +1.5 -120 + N/A +1.5 -120 + N/A N/A N/A +6.5 -105  
Arizona Cardinals 270 Cardinals
-4.5 -110 -0.5 -130 + N/A -2.5 -110 + -1.5 even + N/A -1.5 -102 + N/A N/A N/A -6.5 -115  
Carolina Panthers 269 Panthers
o46.5 -110 o12.5 -110 + N/A o12.5 -112 + o12.5 -110 + N/A o12.5 -110 + N/A N/A N/A o44.5 -105  
Arizona Cardinals 270 Cardinals
u46.5 -110 u12.5 -110 + N/A u12.5 -108 + u12.5 -110 + N/A u12.5 -110 + N/A N/A N/A u44.5 -115  
Carolina Panthers 269 Panthers
+164 +150 + N/A +154 + +145 + N/A +136 + N/A N/A N/A +235  
Arizona Cardinals 270 Cardinals
-198 -180 + N/A -185 + -175 + N/A -168 + N/A N/A N/A -290  

The Panthers will take on the Cardinals in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at State Farm Stadium in Glendale, Ariz. The game will be broadcast live on CBS. Here's everything you need to know about Panthers vs. Cardinals odds, the latest NFL spreads, NFL over/unders and more.

The Cardinals opened as a -6.5 point favorite over Panthers. The total is set at over/under 44.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Carolina Panthers vs. Arizona Cardinals Best Bet

Carolina gave up 653 more rushing yards than the next-closest team in 2024. They gave up the 3rd-most yards before contact per attempt AND the 3rd-most yards after contact per attempt. The Panthers spent some cash in free agency to improve up front, adding defensive tackles Tershawn Wharton and Bobby Brown III after whiffing on Milton Williams. They also got defensive tackle Derrick Brown back from injury. They have to be better on the ground, right? Right?!

Nope. Jacksonville torched Carolina for 200 yards on 32 carries in Week 1. Travis Etienne led the way with 143 yards on 16 carries. It was his first 100-yard rushing game since Week 5 of 2023. Etienne topped out at 68 yards last season. The Panthers gave up the 4th-most yards before contact per attempt and the 3rd-most yards after contact per attempt in the opener. To make matters worse, Wharton hurt his hamstring and has already been ruled out for Week 2.

Conner didn't do much in Week 1, but the role remained strong. He posted a 63.9% snap share and handled 60% of the running back rush attempts, in line with his 2024 marks (60.4% and 54.1%, respectively). Backup Trey Benson posted 8 carries for 69 yards, though his increased workload didn't come at Conner's expense. Benson basically took the Emari Demercado/Michael Carter snaps from last season in addition to his normal backup work. Conner and Benson were the only RBs to see the field against New Orleans. Both backs should be in store for solid production this week.

Denver Broncos vs. Indianapolis Colts: James Conner o65.5 Rushing Yards (-130)

(Pick via Charlie Wright)


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What Time is the Carolina Panthers vs. Arizona Cardinals Game?

The Carolina Panthers will take on the Arizona Cardinals at 4:05 ET on Sunday, September 14th.

Where is the Carolina Panthers vs. Arizona Cardinals Game Being Played?

This game is going to be played at State Farm Stadium in Glendale, AZ.

How Can I Watch the Carolina Panthers vs. Arizona Cardinals?

You can watch The Panthers vs. The Cardinals on CBS.

Can The Panthers Beat The Cardinals?

The Panthers can certainly beat Arizona. They are just under a touchdown underdog. Anything can happen!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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