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Featured Last Updated Sep 30 2025, 3:50 PM

Thursday Night Football Same Game Parlay: 49ers vs. Rams

Nick Galaida
Nick Galaida Sports Betting Expert
9 minute read
Thursday Night Football Same Game Parlay: 49ers vs. Rams

Image Credit: Jayne Kamin-Oncea-Imagn Images

Ready for Thursday Night Football between the 49ers and Rams with an NFL Same Game Parlay that pays out +490?  Follow along as NFL betting expert, Nick Galaida, breaks down his SGP picks for Thursday, October 2.

Be sure to check out the NFL odds and stay up to date with the latest line moves with our NFL Week 5 odds report!

Updated on 9/30/25

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Week 5 of the NFL season will begin with the 49ers and Rams meeting for an early-season divisional matchup on Thursday Night Football. Kickoff is set for 8:15 p.m. ET on Prime Video.

San Francisco finally suffered their first loss of the young season in Week 4, losing at home to Jacksonville 26-21. It’s worth noting that it was the first game this season that star edge rusher Nick Bosa was not on the field for the 49ers.

The Rams trailed in the 4th quarter this past Sunday against the Colts, but Matthew Stafford threw a pair of late touchdown passes, including an 88-yard connection to Tutu Atwell, to help Los Angeles avoid a home upset en route to moving to 3-1.

The winner of Thursday’s matchup between these two teams will take control of first place in the NFC West.

SF @ LA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 301 49ers
+1.5 -110 +3.5 -110 + +8.5 -275 + +3.5 -112 + +3.5 -110 + +3.5 -115 + +3.5 -110 + +3.5 -110 + +3.5 -110 +3.5 -114 + +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 -3.5 -110 + -8.5 +200 + -3.5 -108 + -3.5 -110 + -3.5 -115 + -3.5 -110 + -3.5 -110 + -3.5 -110 -3.5 -109 + -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o23.5 even + N/A o22.5 -122 + o23.5 even + N/A o23.5 -110 + o23.5 even + o24.5 +115 o23.5 -113 + o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u23.5 -120 + N/A u22.5 +102 + u23.5 -120 + N/A u23.5 -110 + u23.5 -120 + u24.5 -140 u23.5 -114 + u46.5 -108  
San Francisco 49ers 301 49ers
+102 +165 + N/A +170 + +170 + +170 + +176 + N/A +175 +170 + +245  
Los Angeles Rams 302 Rams
-122 -200 + N/A -205 + -205 + -240 + -220 + N/A -210 -220 + -290  
San Francisco 49ers 301 49ers
+1.5 -110 +0.5 -130 + +0.5 -130 + +0.5 -120 + +0.5 -130 + +0.5 -130 + +1.5 -128 + +0.5 -125 + +1.5 -135 +1.5 -125 + +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 -0.5 +110 + -0.5 even + -0.5 even + -0.5 even + -0.5 even + -1.5 +106 + -0.5 +105 + -1.5 even -1.5 even + -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o9.5 -105 + N/A o8.5 -110 + o8.5 -115 + o8.5 -120 + o9.5 -108 + o7.5 -110 + o8.5 -115 o9.5 -129 + o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u9.5 -115 + N/A u8.5 -110 + u8.5 -115 + u8.5 -110 + u9.5 -114 + u7.5 -110 + u8.5 -115 u9.5 even + u46.5 -108  
San Francisco 49ers 301 49ers
+102 +130 + N/A +136 + +130 + +130 + +138 + N/A +135 +140 + +245  
Los Angeles Rams 302 Rams
-122 -155 + N/A -162 + -160 + -170 + -170 + N/A -175 -177 + -290  
San Francisco 49ers 301 49ers
+1.5 -110 +3 -110 + N/A +3.5 -112 + +3.5 -110 + N/A +2.5 +105 + N/A N/A +2.5 even + +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 -3 -110 + N/A -3.5 -108 + -3.5 -110 + N/A -2.5 -125 + N/A N/A -2.5 -125 + -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o21.5 -110 + N/A o23.5 -112 + o23.5 -105 + N/A o23.5 -100 + o23.5 -115 + N/A o22.5 -127 + o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u21.5 -110 + N/A u23.5 -108 + u23.5 -115 + N/A u23.5 -120 + u23.5 -115 + N/A u22.5 even + u46.5 -108  
San Francisco 49ers 301 49ers
+102 +145 + N/A +170 + N/A N/A +158 + N/A N/A +155 + +245  
Los Angeles Rams 302 Rams
-122 -170 + N/A -205 + N/A N/A -186 + N/A N/A -195 + -290  
San Francisco 49ers 301 49ers
+1.5 -110 N/A N/A +2.5 -105 + +2.5 -105 + N/A +2.5 -102 + +2.5 -110 + N/A N/A +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 N/A N/A -2.5 -115 + -2.5 -115 + N/A -2.5 -118 + -2.5 -120 + N/A N/A -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o13.5 -110 + N/A o13.5 -105 + o14.5 even + N/A o14.5 -100 + o13.5 -120 + N/A N/A o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u13.5 -110 + N/A u13.5 -115 + u14.5 -125 + N/A u14.5 -122 + u13.5 -110 + N/A N/A u46.5 -108  
San Francisco 49ers 301 49ers
+102 +165 + N/A +150 + +150 + N/A +154 + N/A N/A N/A +245  
Los Angeles Rams 302 Rams
-122 -200 + N/A -185 + -190 + N/A -192 + N/A N/A N/A -290  
San Francisco 49ers 301 49ers
+1.5 -110 N/A N/A +0.5 -105 + +1.5 -125 + N/A +1.5 -128 + +0.5 -115 + N/A N/A +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 N/A N/A -0.5 -115 + -1.5 even + N/A -1.5 +104 + -0.5 -115 + N/A N/A -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o9.5 -110 + N/A o9.5 -135 + o9.5 -125 + N/A o9.5 -130 + o9.5 -135 + N/A N/A o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u9.5 -110 + N/A u9.5 +114 + u9.5 even + N/A u9.5 +108 + u9.5 +105 + N/A N/A u46.5 -108  
San Francisco 49ers 301 49ers
+102 +145 + N/A +150 + +135 + N/A +138 + N/A N/A N/A +245  
Los Angeles Rams 302 Rams
-122 -170 + N/A -175 + -165 + N/A -170 + N/A N/A N/A -290  
San Francisco 49ers 301 49ers
+1.5 -110 +0.5 -115 + N/A +1.5 -108 + +1.5 -125 + N/A +1.5 -124 + +2.5 -110 + N/A N/A +6.5 -112  
Los Angeles Rams 302 Rams
-1.5 -110 -0.5 -105 + N/A -1.5 -112 + -1.5 even + N/A -1.5 +102 + -2.5 -120 + N/A N/A -6.5 -108  
San Francisco 49ers 301 49ers
o47.5 -110 o13 -110 + N/A o13.5 -102 + o13.5 even + N/A o12.5 -128 + o13.5 -110 + N/A N/A o46.5 -112  
Los Angeles Rams 302 Rams
u47.5 -110 u13 -110 + N/A u13.5 -118 + u13.5 -125 + N/A u12.5 +106 + u13.5 -120 + N/A N/A u46.5 -108  
San Francisco 49ers 301 49ers
+102 +125 + N/A +145 + +125 + N/A +128 + N/A N/A N/A +245  
Los Angeles Rams 302 Rams
-122 -150 + N/A -175 + -155 + N/A -158 + N/A N/A N/A -290  

As always, it is worth noting that straight wagers are a far more profitable long-term betting strategy than parlays. Still, parlays can be a fun way to get some extra action on a game to make things interesting!

Looking to get in on the action? Be sure to check out the latest bet365 promo code!

Thursday Night Football - Same Game Parlay Picks Today

  • Los Angeles Rams ML
  • Kyren Williams 10+ Rush Attempts
  • Blake Corum 50+ Rushing Yards

PAYOUT: +490

Los Angeles Rams ML (-250)

Though both of these teams are 3-1 through their first 4 games, it’s difficult not to feel as though the 49ers and Rams are trending in opposite directions. In the last two weeks, San Francisco has lost starting LG Ben Bartch and star EDGE Nick Bosa to injured reserve. WR Brandon Aiyuk and TE George Kittle were already on injured reserve from earlier in the season. Meanwhile, the Rams returned LG Steve Avila to their lineup in Week 4, giving them their optimal starting five offensive linemen for the first time since Week 1. Defensively, 10 of their 11 Week 1 starters remain healthy.

The 49ers roster began the year replete with stars, but the trade-off for that type of roster construction is that there usually isn’t much quality depth available in the event that the top guys go down with injuries. We have seen San Francisco struggle each of the last two weeks, and there isn’t much evidence to suggest that’s going to turn around on Thursday against the Rams—a legit Super Bowl contender.

Kyren Williams 10+ Rush Attempts (-320)

Williams has been losing some snaps to backup running back Blake Corum, but not enough to be concerned that he’s suddenly going to lose his role as the team's lead option on the ground. Williams has received 10+ rush attempts in every game he’s played since the beginning of 2023. That should once again be the case on Thursday against the 49ers.

Blake Corum 50+ Rushing Yards (+375)

Corum played only 10 snaps in Week 1 but played 18 snaps in Week 2 and saw a season-high 22 snaps in Week 4 in a competitive game against the Colts. The 2024 3rd-round draft pick out of Michigan appears to be carving out a slightly larger role for himself in this backfield each week. San Francisco’s run defense hasn’t been overly impressive early this fall—notably, they allowed a 48-yard run and 124 rushing yards overall to Travis Etienne Jr. this past Sunday. If Corum can break one long run, he could have a legitimate chance to get to this rushing milestone.

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