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Saints vs Rams Prediction, Picks, Odds | Thursday Night Football Week 16

Michael Crosson
Michael Crosson Sports Betting Expert
5 minute read

Here's everything you need to know about the Saints vs. Rams Picks, Predictions, and Odds for Thursday Night Football Week 16.

Week 16 of the NFL regular season kicks things off with Thursday Night Football between the New Orleans Saints and Los Angeles Rams. Coverage begins from SoFi Stadium in Inglewood, California at 8:15 p.m. ET on Amazon Prime Video. For more on all things NFL, check out our Superbowl odds.

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Saints vs Rams Prediction, Picks & Betting Odds for Thursday Night Football Week 16

Matchup Spread Total Moneyline

After finishing third in the NFC West with a record of 5-12 last year, the Rams weren’t expected to make much noise in terms of playoff contention this season – and as anticipated, they were quiet in the early goings. The Rams posted losses in six of nine contests to open the season to fall to a record of 3-6 entering their bye week, and the future didn’t look very bright with QB Matt Stafford sidelined due to a thumb injury and his overall health status unknown for the foreseeable future.

However, Stafford returned to action immediately following LA’s Week 10 bye, and to the surprise of many, the Rams have played near-perfect football since that point. The Rams enter this week following wins in four of their last five games, while scoring 28-plus points in four of those contests – and their only loss during that span came in an overtime shootout against a top shelf contender in Baltimore.

That said, the Saints are still well within striking distance of locking down a playoff spot, as they enter this contest tied with Tampa Bay atop the NFC South standings with a record of 7-7 coming off back-to-back blowout victories over the Panthers and Giants.

Not too long ago, however, the vast majority was deeply concerned about this New Orleans team, considering the Saints entered their latest two-game stretch (vs. two terrible teams) riding a three-game skid consisting of losses to the Vikings, Falcons, and Lions – while scoring 19 points or less in two of those contests, and surrendering 24-plus points on defense in all three.

The fact of the matter is, the Saints run up the score against bad defensive units and they struggle to score against the good ones – which has led to generally misleading scoring averages on both sides of the ball. New Orleans ranks 12th in points scored and 6th in points allowed. However, those numbers are heavily skewed by averaging 30.4 PPG in matchups against the Panthers, Giants, Patriots, Lions and Colts, as opposed to averaging just 17.4 PPG in their other nine contests.

Moving the ball up and down the field isn’t easy against LA, though. The Rams have held their opponent to 20 points or less in five of their last six games. While on the flip side, the Rams have also scored 28-plus points in four straight. 

Believe it or not, LA has emerged as one of the “teams that nobody wants to play” down the stretch. While contrarily, the most impressive win on the Saints’ resume came against Indianapolis back in Week 8, with six of their seven wins coming against teams below .500. I’m laying the points with the Rams on Thursday night.

Score Prediction: Rams 27, Saints 17
Best Bet: Rams -4 (-110)

NO @ LAR Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
New Orleans Saints 451 Saints
+4 -110 +3 -110 +2.5 -100 +3 -115 +3 even +3.5 -122 +2.5 +102 +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -3 -110 -2.5 -120 -3 -105 -3 -120 -3.5 +102 -2.5 -130 -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o21.5 -115 o22.5 -110 N/A o22 -110 o22.5 -115 o21.5 -113 o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u21.5 -105 u22.5 -110 N/A u22 -110 u22.5 -105 u21.5 -110 u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +150 +136 +140 +148 +154 +138 +176  
Los Angeles Rams 452 Rams
-196 -180 -166 -165 -175 -185 -175 -210  
Final
New Orleans Saints 451 Saints
+4 -110 +1.5 -105 +2.5 -110 N/A +2.5 -105 N/A +1.5 -114 +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -1.5 -115 -2.5 -110 N/A -2.5 -115 N/A -1.5 -109 -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o22.5 -115 o22.5 -105 N/A o22.5 -120 N/A o23.5 -104 o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u22.5 -105 u22.5 -115 N/A u22.5 even N/A u23.5 -121 u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +130 +136 N/A N/A N/A +120 +176  
Los Angeles Rams 452 Rams
-196 -155 -160 N/A N/A N/A -148 -210  
Final
New Orleans Saints 451 Saints
+4 -110 +0.5 -125 +1.5 -142 +0.5 -130 +0.5 -125 +0.5 -118 +1.5 -132 +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -0.5 +105 -1.5 +116 -0.5 even -0.5 +105 -0.5 -102 -1.5 +106 -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o7.5 -115 o7.5 -114 N/A o7.5 +110 o9.5 -112 o7.5 -109 o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u7.5 -105 u7.5 -108 N/A u7.5 -130 u9.5 -108 u7.5 -114 u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +135 +132 +125 +135 +136 +128 +176  
Los Angeles Rams 452 Rams
-196 -160 -164 -160 -160 -162 -159 -210  
Final
New Orleans Saints 451 Saints
+4 -110 +0.5 -105 +1.5 -112 N/A N/A +0.5 -135 N/A +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -0.5 -115 -1.5 -108 N/A N/A -0.5 +105 N/A -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o13.5 -110 o10.5 -102 N/A N/A o9.5 +105 N/A o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u13.5 -110 u10.5 -132 N/A N/A u9.5 -135 N/A u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +130 +128 N/A N/A +124 N/A +176  
Los Angeles Rams 452 Rams
-196 -155 -158 N/A N/A -148 N/A -210  
Final
New Orleans Saints 451 Saints
+4 -110 +0.5 -130 +1.5 -140 N/A N/A +0.5 -125 N/A +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -0.5 +110 -1.5 +116 N/A N/A -0.5 +105 N/A -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o9.5 -115 o10.5 +118 N/A N/A o9.5 -115 N/A o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u9.5 -105 u10.5 -156 N/A N/A u9.5 -105 N/A u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +125 +118 N/A N/A +124 N/A +176  
Los Angeles Rams 452 Rams
-196 -150 -144 N/A N/A -148 N/A -210  
Final
New Orleans Saints 451 Saints
+4 -110 +0.5 -110 +1.5 -132 N/A N/A +0.5 -115 N/A +4.5 -114  
Los Angeles Rams 452 Rams
-4 -110 -0.5 -110 -1.5 +108 N/A N/A -0.5 -105 N/A -4.5 -106  
Final
New Orleans Saints 451 Saints
o44.5 -110 o13.5 -110 o13.5 +104 N/A N/A o13.5 -112 N/A o45.5 -104  
Los Angeles Rams 452 Rams
u44.5 -110 u13.5 -110 u13.5 -126 N/A N/A u13.5 -108 N/A u45.5 -118  
Final
New Orleans Saints 451 Saints
+164 +120 +116 N/A N/A +114 N/A +176  
Los Angeles Rams 452 Rams
-196 -140 -142 N/A N/A -135 N/A -210  

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Saints vs Rams Betting Resources

Date: Thursday, December 21, 2023
Matchup: NFC South vs. NFC West
Venue: SoFi Stadium
Location: Inglewood, California
Time-TV: Amazon Prime Video, 8:15 p.m. ET

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 16 Report containing spreads, lines, and trends for every NFL matchup.

Use our BetMGM bonus code before making your Saints vs. Rams picks to get bonus bets!

New Orleans Saints Betting Analysis

New Orleans owns a record of 7-7 entering this week as the Saints still control their own destiny regarding playoff contention currently tied with Tampa Bay atop the NFC South standings – and they still have another date set with the Bucs in Week 17, which could potentially determine the No. 4 seed in the NFC.

However, even if they don’t win the division, there’s still a chance that the Saints could sneak into the playoffs via wild card, considering they also find themselves in a four-way tie for the final two NFC wild card spots with the Vikings, Rams, Seahawks, and Saints all deadlocked at 7-7 with three games left to play. A lot could happen in the next three weeks.

Los Angeles Rams Betting Analysis

According to VegasInsider’s Patrick Everson, the spread for this contest originally opened at Rams -3.5 on Sunday night, and then quickly moved to Rams -4  with LA seemingly playing its best ball of the season right now – and not to mention, New Orleans also owns a lackluster record of 3-4 on the road so far this season.

Saints vs Rams Betting Trends

  • The Saints are 4-10-1 ATS in their last 15 games.
  • The total has gone UNDER in 16 of New Orleans' last 20 games.
  • The Rams are 4-1 ATS in their last five games.
  • The Rams are 4-1 SU in their last five games.
  • The total has gone UNDER in five of the Rams' last six home games.
  • The Saints are 4-8 ATS in their last 12 games against the Rams.

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Michael Crosson

Michael Crosson

Michael Crosson began his time at VegasInsider as a freelance NBA writer back in 2019 while he continued to study Psychology and Biology at James Madison University. Following his graduation in 2021, Michael joined the team full-time, and he's been with VI ever since. Michael still writes NBA, NFL, and MLB for VI, as well as gambling industry news. He's also become a crucial part of our editorial production team. More from Michael Crosson
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