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Featured Last Updated Oct 27 2025, 4:52 PM

NFL: Indianapolis Colts vs. Pittsburgh Steelers Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Indianapolis Colts vs. Pittsburgh Steelers Prediction, Odds, Best Bet

Featured Image Credit: Gary A. Vasquez-Imagn Images

IND @ PIT Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indianapolis Colts 457 Colts
+3.5 -110 -2 -110 + N/A -1.5 -110 + -2.5 -105 + N/A -2.5 -120 + N/A -2.5 -105 N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +2 -110 + N/A +1.5 -110 + +2.5 -117 + N/A +2.5 -100 + N/A +2.5 -115 N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 o25 -110 + N/A o25.5 -112 + o24.5 -117 + N/A o24.5 -100 + N/A o24.5 -110 N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u25 -110 + N/A u25.5 -108 + u24.5 -105 + N/A u24.5 -120 + N/A u24.5 -110 N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 -150 + N/A -148 + -164 + N/A -172 + N/A -150 N/A -170  
Pittsburgh Steelers 458 Steelers
-175 +125 + N/A +124 + +135 + N/A +140 + N/A +125 N/A +142  
Indianapolis Colts 457 Colts
+3.5 -110 -0.5 +110 + N/A -0.5 +120 + N/A N/A -1.5 +104 + N/A -0.5 +110 N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +0.5 -130 + N/A +0.5 -142 + N/A N/A +1.5 -126 + N/A +0.5 -150 N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 o9.5 -130 + N/A o9.5 -135 + N/A N/A o9.5 -124 + N/A o8.5 -150 N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u9.5 +110 + N/A u9.5 +114 + N/A N/A u9.5 +102 + N/A u8.5 +110 N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 -155 + N/A -135 + N/A N/A -176 + N/A -145 N/A -170  
Pittsburgh Steelers 458 Steelers
-175 +130 + N/A +114 + N/A N/A +142 + N/A +110 N/A +142  
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A N/A N/A N/A -1.5 +115 + N/A N/A N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A N/A N/A N/A +1.5 -135 + N/A N/A N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 N/A N/A N/A N/A N/A o23.5 -120 + N/A N/A N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 N/A N/A N/A N/A N/A u23.5 -100 + N/A N/A N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 N/A N/A N/A N/A N/A -124 + N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 N/A N/A N/A N/A N/A +106 + N/A N/A N/A +142  
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A N/A N/A N/A -1.5 +110 + N/A N/A N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A N/A N/A N/A +1.5 -134 + N/A N/A N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 N/A N/A N/A N/A N/A o14.5 -110 + N/A N/A N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 N/A N/A N/A N/A N/A u14.5 -110 + N/A N/A N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 N/A N/A N/A N/A N/A -140 + N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 N/A N/A N/A N/A N/A +114 + N/A N/A N/A +142  
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A N/A N/A N/A +1.5 -182 + N/A N/A N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A N/A N/A N/A -1.5 +148 + N/A N/A N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 N/A N/A N/A N/A N/A o9.5 -134 + N/A N/A N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 N/A N/A N/A N/A N/A u9.5 +110 + N/A N/A N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 N/A N/A N/A N/A N/A -110 + N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 N/A N/A N/A N/A N/A -110 + N/A N/A N/A +142  
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A N/A N/A N/A -1.5 +122 + N/A N/A N/A -3 -115  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A N/A N/A N/A +1.5 -148 + N/A N/A N/A +3 -105  
Indianapolis Colts 457 Colts
o44.5 -105 N/A N/A N/A N/A N/A o13.5 -110 + N/A N/A N/A o49.5 -115  
Pittsburgh Steelers 458 Steelers
u44.5 -115 N/A N/A N/A N/A N/A u13.5 -110 + N/A N/A N/A u49.5 -105  
Indianapolis Colts 457 Colts
+145 N/A N/A N/A N/A N/A -130 + N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 N/A N/A N/A N/A N/A +106 + N/A N/A N/A +142  

The Colts will take on the Steelers in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Acrisure Stadium in Pittsburgh, Pa. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Steelers odds, the latest NFL spreads, NFL over/unders and more.

The Colts opened as a -3 point favorite over Steelers. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/27/25

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Indianapolis Colts vs. Pittsburgh Steelers Best Bet

The Colts are currently running the National Football League. Daniel Jones is this years' Sam Darnold, and the Colts are demolishing just about every team they face. They have one of the strongest offenses in football, and Jonathan Taylor is having a renaissance. The Colts are 4th in 3rd-down success rate, 1st in 4th-down success rate, and top 10 in red-zone conversion rate.

This Colts offense is going to have their way with a Steelers defense that has struggled immensely this season.

Indianapolis Colts vs. Pittsburgh Steelers Best Bet: Indianapolis Colts -3 (-110)

(Pick from Dylan Wilkerson)


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What Time is the Indianapolis Colts vs. Pittsburgh Steelers Game?

The Indianapolis Colts vs. Pittsburgh Steelers game is at 1:00 PM ET on Sunday, October 26th.

Where is the Indianapolis Colts vs. Pittsburgh Steelers Game Being Played?

This game will be played at Acrisure Stadium in Pittsburgh, PA.

How Can I Watch Indianapolis Colts vs. Pittsburgh Steelers?

You can watch Indianapolis Colts vs. Pittsburgh Steelers on FOX.

Can the Colts Beat the Steelers?

Of course! The Colts are actually a favorite so sportsbooks think the Colts will win.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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