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NFL: Indianapolis Colts vs. Pittsburgh Steelers Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Indianapolis Colts vs. Pittsburgh Steelers Prediction, Odds, Best Bet

Featured Image Credit: Gary A. Vasquez-Imagn Images

IND @ PIT Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Indianapolis Colts 457 Colts
+3.5 -110 -2.5 -110 -2.5 -110 -0.5 -102 -2.5 -110 -2.5 -125 -2.5 -110 -2.5 -110 -1.5 +104 -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +2.5 -110 +2.5 -110 +0.5 -118 +2.5 -110 +2.5 -105 +2.5 -110 +2.5 -110 +1.5 -129 +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o25.5 -120 N/A o25.5 -110 o26 -113 o24.5 -110 o25.5 -120 o26.5 even o25.5 -112 o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u25.5 even N/A u25.5 -110 u26 -108 u24.5 -110 u25.5 even u26.5 -120 u25.5 -112 u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -155 -160 -125 -164 -182 N/A -160 -130 -170  
Pittsburgh Steelers 458 Steelers
-175 +130 +135 +105 +130 +134 N/A +130 +104 +145  
Final
Indianapolis Colts 457 Colts
+3.5 -110 -0.5 +105 -0.5 even -0.5 even N/A -1.5 +108 -0.5 +110 -0.5 even -1.5 +145 -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +0.5 -125 +0.5 -130 +0.5 -122 N/A +1.5 -118 +0.5 -130 +0.5 -135 +1.5 -182 +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o9.5 -130 N/A o9.5 -122 N/A o9.5 -126 o9.5 -135 o8.5 -155 o9.5 -120 o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u9.5 +110 N/A u9.5 +102 N/A u9.5 +114 u9.5 +115 u8.5 +115 u9.5 -104 u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -155 -165 -175 N/A -188 N/A -165 -115 -170  
Pittsburgh Steelers 458 Steelers
-175 +130 +130 +142 N/A +138 N/A +125 -108 +145  
Final
Indianapolis Colts 457 Colts
+3.5 -110 -1 -110 N/A -2.5 -118 N/A -1.5 -140 N/A N/A -2.5 -110 -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +1 -110 N/A +2.5 -102 N/A +1.5 -135 N/A N/A +2.5 -113 +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o25.5 -110 N/A o25.5 -115 N/A o24.5 -100 o25.5 -120 N/A o24.5 -113 o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u25.5 -110 N/A u25.5 -105 N/A u24.5 -110 u25.5 -110 N/A u24.5 -110 u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -130 N/A -175 N/A -116 N/A N/A -167 -170  
Pittsburgh Steelers 458 Steelers
-175 +110 N/A +145 N/A -100 N/A N/A +135 +145  
Final
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A -0.5 +102 N/A --1.5 +106 -0.5 -110 N/A N/A -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A +0.5 -122 N/A +-1.5 +108 +0.5 -120 N/A N/A +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o15.5 -110 N/A o15.5 -122 N/A o15.5 -118 o16.5 even N/A N/A o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u15.5 -110 N/A u15.5 +102 N/A u15.5 -132 u16.5 -130 N/A N/A u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -130 N/A -125 N/A -142 N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 +110 N/A +105 N/A +114 N/A N/A N/A +145  
Final
Indianapolis Colts 457 Colts
+3.5 -110 N/A N/A -0.5 +124 N/A --1.5 +150 -0.5 +120 N/A N/A -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 N/A N/A +0.5 -148 N/A +-1.5 +140 +0.5 -160 N/A N/A +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o10 -120 N/A o10.5 +110 N/A o9.5 +120 o10.5 +105 N/A N/A o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u10 even N/A u10.5 -130 N/A u9.5 -700 u10.5 -135 N/A N/A u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -130 N/A -120 N/A -115 N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 +110 N/A -102 N/A -110 N/A N/A N/A +145  
Final
Indianapolis Colts 457 Colts
+3.5 -110 -0.5 +105 N/A -0.5 -108 N/A --1.5 +124 -1.5 -120 N/A N/A -3 -120  
Pittsburgh Steelers 458 Steelers
-3.5 -110 +0.5 -125 N/A +0.5 -112 N/A +-1.5 +122 +1.5 -110 N/A N/A +3 even  
Final
Indianapolis Colts 457 Colts
o44.5 -105 o15.5 -110 N/A o14.5 +102 N/A o13.5 -104 o14.5 even N/A N/A o51.5 -110  
Pittsburgh Steelers 458 Steelers
u44.5 -115 u15.5 -110 N/A u14.5 -122 N/A u13.5 -132 u14.5 -130 N/A N/A u51.5 -110  
Final
Indianapolis Colts 457 Colts
+145 -125 N/A -142 N/A -128 N/A N/A N/A -170  
Pittsburgh Steelers 458 Steelers
-175 +105 N/A +120 N/A +104 N/A N/A N/A +145  

The Colts will take on the Steelers in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Acrisure Stadium in Pittsburgh, Pa. The game will be broadcast live on CBS. Here's everything you need to know about Colts vs. Steelers odds, the latest NFL spreads, NFL over/unders and more.

The Colts opened as a -3 point favorite over Steelers. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 4/18/26

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Indianapolis Colts vs. Pittsburgh Steelers Best Bet

The Colts are currently running the National Football League. Daniel Jones is this years' Sam Darnold, and the Colts are demolishing just about every team they face. They have one of the strongest offenses in football, and Jonathan Taylor is having a renaissance. The Colts are 4th in 3rd-down success rate, 1st in 4th-down success rate, and top 10 in red-zone conversion rate.

This Colts offense is going to have their way with a Steelers defense that has struggled immensely this season.

Indianapolis Colts vs. Pittsburgh Steelers Best Bet: Indianapolis Colts -3 (-110)

(Pick from Dylan Wilkerson)


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What Time is the Indianapolis Colts vs. Pittsburgh Steelers Game?

The Indianapolis Colts vs. Pittsburgh Steelers game is at 1:00 PM ET on Sunday, October 26th.

Where is the Indianapolis Colts vs. Pittsburgh Steelers Game Being Played?

This game will be played at Acrisure Stadium in Pittsburgh, PA.

How Can I Watch Indianapolis Colts vs. Pittsburgh Steelers?

You can watch Indianapolis Colts vs. Pittsburgh Steelers on FOX.

Can the Colts Beat the Steelers?

Of course! The Colts are actually a favorite so sportsbooks think the Colts will win.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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