Last Updated Sep 09, 2021, 5:00 PM

Cardinals vs. Titans Predictions, Odds, Picks

Sept. 12, 2021
Kevin Rogers
VI Betting Expert

Arizona Cardinals vs. Tennessee Titans Predictions

Score Prediction - Cardinals 27, Titans 24

The expectations remain high on Ryan Tannehill, Derrick Henry, and the rest of the Titans after a pair of playoff appearances the last two seasons.

Arizona is stuck in a tough division along with Los Angeles, San Francisco, and Seattle, all teams that have been to at least one Super Bowl since 2014.

The Cardinals boast a strong combination of Kyler Murray and DeAndre Hopkins offensively as this is a good opportunity for them to pull off a road upset in Week 1.

Arizona Cardinals vs. Tennessee Titans Best Bets

  • Arizona +3

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Arizona Cardinals vs. Tennessee Titans Game Odds

  • Arizona +135
  • Tennessee -155
  • Arizona +3 (-110)
  • Tennessee -3 (-110)
  • Over 51.5 (-110)
  • Under 51.5 (-110)

Odds per BetMGM - Subject to Change

Arizona Cardinals vs. Tennessee Titans Betting Resources

  • Venue: Nissan Stadium
  • Location: Nashville, Tennessee
  • TV-Time: CBS - 1:00 p.m. ET

Arizona Cardinals vs. Tennessee Titans Betting Analysis

The Cardinals were in the playoff hunt until a Week 17 to the Rams as Arizona finished 8-8 in head coach Kliff Kingsbury's second year as head coach.

2020 was a roller coaster season in the desert as Arizona put together a pair of two-game winning streak and a three-game hot stretch, but the Cards also lost consecutive contests twice and dropped three straight from Week 11 through Week 13.

The Cardinals cashed the Under in 11 of 16 games last season, including in each of the first six contests. Arizona has covered in its last two opening day contests and are 7-3-2 ATS in past 12 games as a road underdog.

The Titans are coming off an AFC South title at 11-5 last season before getting bounced by the Ravens in the Wild Card round. Tennessee started last season at 5-0, but failed to cover in its first three wins in the favorite role.

Mike Vrabel's team was the opposite of Arizona from a totals perspective by hitting the Over in 12 of 16 regular season games, including in six of eight contests at Nissan Stadium.

The Tennessee Titans have seen road teams win eight of their last nine season opening games. (AP)

Arizona Cardinals vs. Tennessee Titans Betting Trends

  • Arizona has covered the spread in four straight season opening games when playing as the underdog.
  • Arizona has gone UNDER the point total in eight straight road games.
  • Tennessee has seen the road team win eight of its last nine season opening games.

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