Week 1 NFL Gridiron Betting Angles

Play ON ATS Trend

Matchup: Kansas City at Arizona (CBS, 4:25 p.m. ET)

The Cardinals are 5-0 ATS since 2020 as a 4+ point underdog.  They have won all five games outright!


Matchup: New Orleans at Atlanta (FOX, 1:00 p.m. ET)

The Falcons are 0-6 ATS since November 2019 as home dogs when the total is under 51.

OU Trend

Matchup: Philadelphia at Detroit (FOX, 1:00 p.m. ET)

The Lions are 11-0 OU since 2011 in season openers. 

Choice Trend

Matchup: Indianapolis at Houston (CBS, 1:00 p.m. ET)

The Colts are 6-0 ATS since October 2020 as a road favorite of less than 14 points.

Where to place a bet this NFL Season?

  • Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
  • Check out the North Carolina Sportsbooks just before they launch legal online sports betting.