Last Updated Oct 02, 2022, 1:12 PM

Tennessee Titans vs. Indianapolis Colts Picks, Predictions, Odds

Week 4 of the NFL season continues Sunday afternoon as the Tennessee Titans and Indianapolis Colts square off in an AFC South showdown at Lucas Oil Stadium in Indianapolis, Indiana on Sunday. Coverage begins at 1 p.m. ET on FOX.

TENNESSEE TITANS vs. INDIANAPOLIS COLTS BETTING PREDICTION

The Titans and Colts meet for the first of two regular-season encounters on Sunday. These AFC South Division rivals meet twice every season, and last season it was all Tennessee. The Titans won 34-31 in overtime at Indianapolis on Halloween, and the Titans scratched out a 25-16 in the Music City on Sept. 26, 2021. In fact, Tennessee has won and covered three straight in this series after years of Indianapolis domination both straight-up and against the number.

The Titans finally got off the schneid last week, edging the Las Vegas Raiders at Nissan Stadium in Nashville for a 24-22 win and its first victory of the season. It was a breakout offensive performance compared to the first two losses, too, as Tennessee had scored a total of just 27 points in the first two outings.

The Colts also broke through for their first win, surprising the Kansas City Chiefs at this very same venue, 20-17. The point total actually tied a season high, as Indianapolis also scored 20 in Week 1 in a tie at Houston. The Colts managed to hold the Chiefs to just 58 rushing yards on 23 totes last weekend, and Indy found a way to win despite the fact it allowed five sacks.

Score Prediction: Titans 24, Colts 21
Best Bet: Titans +4 (-115)
Best Bet: OVER 42.5 (-110)

TENNESSEE TITANS vs. INDIANAPOLIS COLTS BETTING ODDS

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TENNESSEE TITANS vs. INDIANAPOLIS COLTS BETTING RESOURCES

Date: Sunday, Oct. 2, 2022
Matchup: AFC South
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
Time-TV: FOX, 1:00 p.m. ET

TENNESSEE TITANS BETTING ANALYSIS

The Titans picked up the win and cover last week after starting out 0-2 SU/ATS. The OVER is also 2-0 in the previous two outings after an UNDER result to kick off the 2022 campaign.

Tennessee has posted a 1-4 ATS mark across the past five games overall, while going 0-4 ATS in the past four games on the road. They're also a dismal 7-21-1 ATS in the past 29 road games against teams with a losing home record, for whatever reason. In addition, Tennessee has struggled in Week 4, going 6-13 ATS across the past 19 seasons.

As far as the totals are concerned, the OVER has been dominant for Tennessee over the long term, going 18-6 in the past 24 road games, while cashing in nine of the past 13 games inside the AFC South Division. The OVER is also 8-1-1 in Tennessee's past 10 games in the month of October, while cashing at a 10-1 clip in the past 11 on a fieldturf surface.

The Colts have cashed the UNDER in 10 of the past 11 divisional games. (Getty Images)

INDIANAPOLIS COLTS BETTING ANALYSIS

The Colts have not been a friend to bettors, but as poor as the results have been in real life, it is just 1-1-1 SU, and very much in the hunt to make some noise in the AFC South despite a slow start. Indianapolis is 0-3 ATS, and the UNDER has hit in each of the past two outings.

Indianapolis is just 1-5 ATS in the past six games inside the AFC South Division, while going 1-4 ATS in the past five games overall, and 2-5 ATS in the past seven chances in Week 4.

On totals, it's all about the UNDER lately, going 8-0 in the past eight games overall, while cashing at a ridiculous 10-1 clip against AFC South foes. The UNDER is 4-1 in the past five home games for the Colts, too.

TENNESSEE TITANS vs. INDIANAPOLIS COLTS BETTING TRENDS

  • Titans are 1-4 ATS in the past five games overall
  • Titans are 0-4 ATS in the past four road games
  • Colts are 1-4 ATS in the past five games overall
  • Colts are 1-5 ATS in the past six vs. AFC South
  • OVER is 18-6 in the past 24 road games for the Titans
  • OVER is 9-4 in the past 13 vs. AFC South for the Titans
  • OVER is 8-1-1 in the past 10 in October for the Titans
  • UNDER is 8-0 in the past eight for the Colts
  • UNDER is 4-1 in the past five home games for the Colts
  • UNDER is 10-1 in the past 11 vs. AFC South for the Colts
  • Favorite is 14-5 ATS in the past 19 meetings
  • Road team is 6-1 ATS in the past seven meetings
  • Titans are 4-1 ATS in the past five meetings
  • Titans are 4-1 ATS in the past five trips to Indianapolis
  • OVER is 4-1 in the past five meetings
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