2026 NCAA Tournament South Region Odds

Kevin Rogers Sports Betting Expert

15 minute read

NCAAB Futures Odds

In the 2025 NCAA Tournament’s South Region, Auburn and Michigan State battled for a spot in the Final Four, with Auburn coming out on top as the regional champion. After defeating Michigan State in the regional final, Auburn advanced to the Final Four, where they fell to Florida. On the other side of the bracket, Houston knocked off Duke to reach the title game. Florida then edged out Houston in the championship to secure the 2025 national title.

Looking for more basketball action? Check out our NBA odds.

Michael O'Connell and the North Carolina State Wolfpack have won three times as underdogs in the South Region. (Getty)

South Region Betting Results

Straight Up (SU)
Against the Spread (ATS)
Over-Under (OU)

Favorites-Underdogs (SU): 9-6
Favorites-Underdogs (ATS): 6-9
Over-Under: 8-7

NCAA Tournament South Region Schedule

First & Second Round Matchups

Thursday, Mar. 26
TBA
TBA

Sweet Sixteen & Elite Eight Matchups

Saturday, April 4
TBA
TBA

Monday, April 6
TBA
TBA

2026 NCAA Tournament South Region Opening Odds

The opening Odds to Win the NCAA Tournament South Region will be presented once they are available at the operator website.

Odds Provided by bet365

The Houston Cougars are listed as +120 favorites to win the South Region of the NCAA Tournament. (Getty)

2026 NCAA Tournament South Region Teams

Listed in Seed Order (Conference - Bid)

1) Houston Cougars
(Big 12, At-Large)

2) Marquette Golden Eagles
(Big East, At-Large)

3) Kentucky Wildcats
(SEC, At-Large)

4) Duke Blue Devils
(ACC, At-Large)

5) Wisconsin Badgers
(Big Ten, At-Large)

6) Texas Tech Red Raiders
(Big 12, At-Large)

7) Florida Gators
(SEC, At-Large)

8) Nebraska Cornhuskers
(Big Ten, At-Large)

9) Texas A&M Aggies
(SEC, At-Large)

10) Colorado Buffaloes
(Pac-12, At-Large)

10) Boise State Broncos
(Mountain West, At-Large)

11) North Carolina State Wolfpack
(ACC, Automatic)

12) James Madison Dukes
(Sun Belt, Automatic)

13) Vermont Catamounts
(America East, Automatic)

14) Oakland Golden Grizzlies
(Horizon, Automatic)

15) Western Kentucky Hilltoppers
(Conference USA, Automatic)

16) Longwood Lancers
(Big South, Automatic)

Key
Futures: Odds to Win NCAA Tournament
Region: Odds to Win East Region
SU: Straight Up
ATS: Against the Spread
O/U: Over-Under
PPG: Points Per Game
OPPG: Opponents Per Game

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Kevin Rogers

Kevin has been handicapping professionally since 2007 at VegasInsider before shifting to ScoresAndOdds. He focuses on MLB, NFL, college football, NBA, college basketball, and NHL and mainly uses trends, systems, and situations as his top handicapping angles. More from Kevin Rogers