College Football Odds Week 6: LSU vs Missouri Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

It's a battle of Tigers in Week 6 of college football in the SEC as Missouri plays host to LSU. Mizzou is undefeated, but betting odds have LSU as a 6.5-point road favorite. Coverage begins from Faurot Field in Columbia on Saturday, October 7 at 12:00 p.m. ET on ESPN.

Here's everything you need to know about the college football odds for Week 6 LSU vs Missouri: the opening lines, spreads, betting trends and more. Check back regularly for updates.

No. 23 LSU vs No. 21 Missouri Odds

LSU looks to rebound after last week's high-scoring loss at Ole Miss. (Getty)
  • Opening point spread: LSU -6.5
  • Opening moneyline: LSU -250/Missouri +205
  • Opening total: Over/Under 62.5 points scored
  • Time: Noon ET Saturday (ESPN)

UPDATE 11:30 A.M. ET SATURDAY: TwinSpires Sportsbook pegged LSU a 7-point road chalk to open, then fell to Tigers -6 en route to the current -5.5. Missouri is landing 60% of spread tickets/64% of spread cash.

"Mizzou is a trendy 'dog. It's hard for bettors to pass up a 5-0 team getting 5.5 points at home," TwinSpires director of retail betting Zachary Lucas said.

The total climbed from 62.5 to 65, then backed up to 64. Tickets and money are in the 2/1 range on the Over at TwinSpires.

UPDATE 1 P.M. ET FRIDAY: LSU opened -6.5 Sunday afternoon at BetMGM and began sliding backwards midweek. On Wednesday, the Tigers went to -6/-5.5, then Thursday fell to -4.5. Late this morning, LSU rebounded to -5.5.

Missouri is seeing a modest majority 53% of spread tickets, while 60% of spread money is on LSU.

The total climbed from 62.5 to 65.5 by Thursday, then receded to 64.5 in the past hour. Tickets and money are both in the 7/1 range on the Over. In fact, by ticket count, this matchup is the second-most-bet Over on the college football Week 6 odds board at BetMGM.

UPDATE 3 P.M. ET MONDAY: In this SEC battle of Tigers, LSU (3-2 SU/2-3 ATS) is the lower-ranked team, on the road, against unbeaten Missouri. But oddsmakers certainly revealed a lot by opening LSU as almost a touchdown chalk.

LSU dug itself into a 21-7 first-quarter hole at No. 20 Ole Miss in Week 4, then rebounded to turn the game into arguably the biggest shootout of this season. LSU took a 49-40 lead midway through the fourth quarter.

But the purple-and-gold Tigers then gave up two touchdowns and lost 55-49 as 3-point favorites.

Missouri (5-0 SU/3-2 ATS) had no such issues with Vanderbilt. The black-and-gold Tigers took a 24-7 lead early in the third quarter and coasted to a 38-21 victory giving 14 points on the road.

Caesars remains at its opener of LSU -6.5. But the total nudged up from 62.5 to 63 in the college football odds Week 6 market.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 6 Report containing spreads, lines, and trends for every Top 25 matchup.