College Football Odds Week 6: Notre Dame vs Louisville Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Louisville vs
Notre Dame
+6.5 (-118)
-6.5 (-104)
o53.5 (-115)
u53.5 (-105)

Week 6 of college football showcases Notre Dame in primetime on the road for a second straight week, this time visiting Louisville. Betting odds have the Fighting Irish as 6.5-point road favorites over the Cardinals. Coverage begins from Louisville on Saturday, October 7 at 7:30 p.m. ET on ABC.

Here's everything you need to know about the college football odds for Week 6 Notre Dame vs Louisville: the opening lines, spreads, betting trends and more. Check back regularly for updates.

No.10 Notre Dame vs No. 25 Louisville Odds

Louisville looks to pull off the upset as a home 'dog against Notre Dame. (Getty)
  • Opening point spread: Notre Dame -6.5
  • Opening moneyline: Notre Dame -250/Louisville +200
  • Opening total: Over/Under 52.5 points scored
  • Time: 7:30 p.m. ET Saturday (ABC)

UPDATE 6:30 P.M. ET: BetMGM Nevada had Notre Dame -7 to open, went to -6.5 Monday and briefly to -6 Wednesday. The line then returned to Fighting Irish -6.5 and hasn't moved since.

"Just over 4/1 tickets in favor of Notre Dame, money roughly 1.5/1 on Notre Dame," BetMGM Nevada's Scott Shelton said. "This is a very popular teaser game in favor of Notre Dame."

The total went from 52.5 to 54.5 early in the week, then 53.5 Thursday. It's now at 53.5 (Under -115) with what Shelton termed "perfect two-way." Tickets are exactly even, and the Over has $1,000 more.

UPDATE 5 P.M. ET THURSDAY: Notre Dame opened -6.5 (-115) and stretched to -7.5 within 30 minutes Sunday night at PointsBet. But the line reverted to -6.5 (-115) about an hour later, and the Fighting Irish dipped to -5.5 midday Wednesday.

Notre Dame is now at -6.5 flat, with tickets 5/1 and money 9/1 on the Irish.

PointsBet's total opened at 53 (Under -115) and dipped to 51.5 a couple times Monday. But it rebounded to 54.5 by Tuesday afternoon and has been at 54 since Tuesday night. The Over is getting 59% of bets, while 80% of cash is on the Under.

UPDATE 3 P.M. ET MONDAY: After falling to Ohio State in Week 4, Notre Dame (5-1 SU and ATS) got a tough game for the second straight week. The Fighting Irish, laying 5.5 points on the road, needed a final-minute touchdown to beat No. 17 Duke 21-14.

Louisville (5-0 SU/2-2-1 ATS) is quietly putting together a good season. The Cardinals edged North Carolina State 13-10 in Week 5, pushing as 3-point road favorites.

Notre Dame hasn't moved off 6.5 at TwinSpires, where 55% of early tickets are on the Irish and 53% of early money is on the Cardinals.

"Good two-way action on the spread so far. On the moneyline, it's 2/1 tickets and 3/1 money Notre Dame," Lucas said.

The moneyline is at Notre Dame -250/Louisville +200. The total is down a point to 51.5 at TwinSpires, with sharp play showing up on Under 52.5.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 6 Report containing spreads, lines, and trends for every Top 25 matchup.