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Featured Last Updated Sep 5 2025, 1:06 PM

Illinois vs. Duke, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
Illinois vs. Duke, Prediction, Odds, Best Bet

Featured Image Credit: James Guillory/USA Today Network via Imagn Images

ILL @ DUKE Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Illinois Fighting Illini 335 Illinois
-3.5 -110 -1 -110 + -1.5 -110 + -0.5 -115 + -0.5 -115 + -0.5 -115 + -1.5 -102 + -0.5 -110 -1.5 -104 + -1.5 -104 -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 +1 -110 + +1.5 -110 + +0.5 -105 + +0.5 -105 + +0.5 -115 + +1.5 -120 + +0.5 -110 +1.5 -121 + +1.5 -121 +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 o24 -105 + N/A o23.5 -115 + o24 -105 + N/A o24.5 +104 + o22.5 -140 o24.5 even + o24.5 even o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 u24 -115 + N/A u23.5 -105 + u24 -115 + N/A u24.5 -128 + u22.5 +110 u24.5 -130 + u24.5 -130 u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 -135 + -140 + -130 + -135 + -130 + -132 + N/A -136 + -136 -135  
Duke Blue Devils 336 Duke
+130 +115 + +115 + +110 + +115 + even + +108 + N/A +105 + +105 +114  
Illinois Fighting Illini 335 Illinois
-3.5 -110 -0.5 +110 + -0.5 +110 + -0.5 +110 + -0.5 +105 + -0.5 +110 + -1.5 +132 + -0.5 +120 -1.5 +117 + -1.5 +117 -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 +0.5 -140 + +0.5 -145 + +0.5 -130 + +0.5 -135 + +0.5 -140 + +1.5 -166 + +0.5 -150 +1.5 -157 + +1.5 -157 +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 o10 -125 + N/A o10.5 +105 + o10 -130 + o10.5 +110 + o10.5 +122 + o10.5 +115 o9.5 -134 + o9.5 -134 o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 u10 -105 + N/A u10.5 -122 + u10 even + u10.5 -140 + u10.5 -152 + u10.5 -145 u9.5 -105 + u9.5 -105 u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 -130 + -135 + -122 + -130 + -125 + -125 + N/A -125 + -125 -135  
Duke Blue Devils 336 Duke
+130 even + even + +102 + even + -105 + -102 + N/A -104 + -104 +114  
Illinois Fighting Illini 335 Illinois
-3.5 -110 N/A N/A -1.5 +114 + +0.5 -125 + N/A N/A N/A N/A N/A -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 N/A N/A +1.5 -135 + -0.5 +105 + N/A N/A N/A N/A N/A +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 N/A N/A o24.5 -102 + o23.5 -120 + N/A N/A N/A N/A N/A o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 N/A N/A u24.5 -118 + u23.5 even + N/A N/A N/A N/A N/A u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 N/A N/A -118 + N/A N/A N/A N/A N/A N/A -135  
Duke Blue Devils 336 Duke
+130 N/A N/A -102 + N/A N/A N/A N/A N/A N/A +114  
Illinois Fighting Illini 335 Illinois
-3.5 -110 N/A N/A -0.5 +110 + N/A N/A -1.5 +110 + N/A N/A N/A -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 N/A N/A +0.5 -140 + N/A N/A +1.5 -146 + N/A N/A N/A +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 o13.5 -120 + N/A o12.5 -120 + N/A N/A o14.5 +110 + N/A N/A N/A o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 u13.5 -110 + N/A u12.5 -110 + N/A N/A u14.5 -138 + N/A N/A N/A u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 -120 + N/A -130 + N/A N/A -132 + N/A N/A N/A -135  
Duke Blue Devils 336 Duke
+130 -110 + N/A even + N/A N/A +104 + N/A N/A N/A +114  
Illinois Fighting Illini 335 Illinois
-3.5 -110 N/A N/A -0.5 +124 + N/A N/A -1.5 +124 + N/A N/A N/A -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 N/A N/A +0.5 -160 + N/A N/A +1.5 -166 + N/A N/A N/A +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 o10.5 -115 + N/A o10.5 +105 + N/A N/A o10.5 +112 + N/A N/A N/A o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 u10.5 -115 + N/A u10.5 -135 + N/A N/A u10.5 -140 + N/A N/A N/A u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 -120 + N/A -125 + N/A N/A -130 + N/A N/A N/A -135  
Duke Blue Devils 336 Duke
+130 -110 + N/A -105 + N/A N/A +102 + N/A N/A N/A +114  
Illinois Fighting Illini 335 Illinois
-3.5 -110 -0.5 +135 + N/A -0.5 +110 + N/A N/A -1.5 +118 + N/A N/A N/A -2.5 -115  
Duke Blue Devils 336 Duke
+3.5 -110 +0.5 -167 + N/A +0.5 -140 + N/A N/A +1.5 -158 + N/A N/A N/A +2.5 -105  
Illinois Fighting Illini 335 Illinois
o49.5 -110 o13.5 -115 + N/A o13.5 -125 + N/A N/A o12.5 -122 + N/A N/A N/A o48.5 -115  
Duke Blue Devils 336 Duke
u49.5 -110 u13.5 -115 + N/A u13.5 -105 + N/A N/A u12.5 -102 + N/A N/A N/A u48.5 -105  
Illinois Fighting Illini 335 Illinois
-155 -115 + N/A -125 + N/A N/A -136 + N/A N/A N/A -135  
Duke Blue Devils 336 Duke
+130 -115 + N/A -105 + N/A N/A +106 + N/A N/A N/A +114  

The Illinois Fighting Illini will take on the Duke Blue Devils in this week's NCAAF action. Kickoff is set for 12:00 p.m. EDT at Brooks Field at Wallace Wade Stadium in Durham, N.C. The game will be broadcast live on ESPN. Here's everything you need to know about Illinois vs. Duke odds, the latest NCAAF spreads, NCAAF over/unders and more.

Illinois opened as a -3 point favorite over Duke. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Illinois Fighting Illini vs. Duke Blue Devils Best Bet

Two schools traditionally known for their basketball programs are each dark horses that could ruffle some feathers in their respective P4 conferences.

Both Illinois and Duke were able to win against FCS opponents in week one and will square off in what should be one of week two's best games on the slate.

Illinois was a trendy team in the College Football Playoff offseason, as it returns 19 starters from a team that won double-digit games a year ago. Under coach Bret Bilemma, the Illini are remarkably sound and well-coached, trying to grind the game away on the ground with stifling defense.

However, the Blue Devils have the edge at signal caller with Tulane transfer Darian Mensah taking snaps. Although Luke Altmeyer is a nice game manager for the Illini, he is not the dynamic playmaker that Mensah is.

In his debut, Mensah threw for 389 yards and three touchdowns. He'll certainly take a step back this week against Illinois, but you can feel reassured that Mensah is a seamless fit in this Duke offense.

On the other side, head coach Manny Diaz loves to heat up opposing quarterbacks with exotic blitzes and pressures. With potential first-round pick Chandler Rivers leading an experienced back-end, this Duke secondary should be able to hold up and create issues for this Illini offense.

Duke is an enticing short moneyline play, but with the number over a key number and having a home field advantage, we'll happily take the points here as Illinois has the potential to win in a close one late.

Illinois vs. Duke Best Bet: Duke +3.5 (-110)

(Pick from Derek Mountain)


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What Time is the Illinois vs. Duke Game?

The Illinois Fighting Illini will take on the Duke Blue Devils at 12:00 ET on Saturday, September 6th.

Where is the Illinois vs. Duke Game Being Played?

This game is going to be played at Wallace Wade Stadium in Durham, NC.

How Can I Watch Illinois vs. Duke?

You can watch Duke vs. Illinois on ESPN.

Can Duke beat Illinois?

Duke can certainly beat Illinois. Although oddsmakers have Illinois as the favorite, it is slight (just 3.5 points). Duke brought in one of the nation's top signal callers in Darian Mensah from the transfer portal, and is expected to make a push for the top of the ACC.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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