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Featured Last Updated Sep 19 2025, 2:01 PM

Indiana vs. Illinois: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Indiana vs. Illinois: Prediction, Odds, Best Bet

Image Credit: Robert Goddin via Imagn Images

ILL @ IU Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Illinois Fighting Illini 329 Illinois
+4.5 -110 +3.5 -110 + +3.5 -110 + +3.5 -110 + +3.5 -110 + +3.5 -110 + +3.5 -105 + +3.5 -110 +3.5 -107 + +3.5 -107 +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -120 + -3.5 -115 + -3.5 -110 -3.5 -115 + -3.5 -115 -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 o26.5 -105 + N/A o26.5 -105 + o26.5 -105 + N/A o27.5 +110 + o24.5 -115 o25.5 -115 + o25.5 -115 o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 u26.5 -115 + N/A u26.5 -115 + u26.5 -115 + N/A u27.5 -134 + u24.5 -105 u25.5 -109 + u25.5 -109 u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 +160 + N/A +160 + +158 + +160 + +160 + N/A +160 + +160 +210  
Indiana Hoosiers 330 Indiana
-175 -190 + N/A -192 + -190 + -220 + -200 + N/A -210 + -210 -258  
Illinois Fighting Illini 329 Illinois
+4.5 -110 +0.5 -110 + +2.5 -115 + +2.5 -105 + +0.5 even + +2.5 -105 + +1.5 -118 + -0.5 +200 +1.5 -114 + +1.5 -114 +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 -0.5 -120 + -2.5 -115 + -2.5 -115 + -0.5 -130 + -2.5 -125 + -1.5 -106 + +0.5 -300 -1.5 -114 + -1.5 -114 -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 o10.5 -120 + N/A o11.5 -110 + o10.5 -105 + o12.5 -120 + o10.5 -104 + o10.5 -115 o10.5 -113 + o10.5 -113 o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 u10.5 -110 + N/A u11.5 -110 + u10.5 -125 + u12.5 -110 + u10.5 -120 + u10.5 -115 u10.5 -115 + u10.5 -115 u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 +130 + N/A +140 + +140 + +160 + +144 + N/A +140 + +140 +210  
Indiana Hoosiers 330 Indiana
-175 -160 + N/A -166 + -170 + -220 + -186 + N/A -182 + -182 -258  
Illinois Fighting Illini 329 Illinois
+4.5 -110 N/A N/A +3.5 -120 + +2.5 -110 + N/A N/A N/A N/A N/A +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 N/A N/A -3.5 even + -2.5 -110 + N/A N/A N/A N/A N/A -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 N/A N/A o26.5 -112 + o26.5 -115 + N/A N/A N/A N/A N/A o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 N/A N/A u26.5 -108 + u26.5 -105 + N/A N/A N/A N/A N/A u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 N/A N/A +160 + N/A N/A N/A N/A N/A N/A +210  
Indiana Hoosiers 330 Indiana
-175 N/A N/A -192 + N/A N/A N/A N/A N/A N/A -258  
Illinois Fighting Illini 329 Illinois
+4.5 -110 N/A N/A +0.5 -115 + N/A N/A +1.5 -114 + N/A N/A N/A +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 N/A N/A -0.5 -115 + N/A N/A -1.5 -114 + N/A N/A N/A -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 o14 -115 + N/A o13.5 -115 + N/A N/A o15.5 -112 + N/A N/A N/A o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 u14 -115 + N/A u13.5 -115 + N/A N/A u15.5 -112 + N/A N/A N/A u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 +155 + N/A +124 + N/A N/A +138 + N/A N/A N/A +210  
Indiana Hoosiers 330 Indiana
-175 -190 + N/A -160 + N/A N/A -178 + N/A N/A N/A -258  
Illinois Fighting Illini 329 Illinois
+4.5 -110 N/A N/A +0.5 -115 + N/A N/A +1.5 -136 + N/A N/A N/A +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 N/A N/A -0.5 -115 + N/A N/A -1.5 +102 + N/A N/A N/A -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 o12.5 -115 + N/A o11.5 -115 + N/A N/A o10.5 -112 + N/A N/A N/A o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 u12.5 -115 + N/A u11.5 -115 + N/A N/A u10.5 -112 + N/A N/A N/A u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 +140 + N/A +135 + N/A N/A +130 + N/A N/A N/A +210  
Indiana Hoosiers 330 Indiana
-175 -170 + N/A -175 + N/A N/A -170 + N/A N/A N/A -258  
Illinois Fighting Illini 329 Illinois
+4.5 -110 +0.5 -130 + N/A +0.5 -110 + N/A N/A +1.5 -144 + N/A N/A N/A +6.5 -105  
Indiana Hoosiers 330 Indiana
-4.5 -110 -0.5 even + N/A -0.5 -120 + N/A N/A -1.5 +108 + N/A N/A N/A -6.5 -115  
Illinois Fighting Illini 329 Illinois
o52.5 -105 o15 -115 + N/A o14.5 even + N/A N/A o13.5 -118 + N/A N/A N/A o52.5 -110  
Indiana Hoosiers 330 Indiana
u52.5 -115 u15 -115 + N/A u14.5 -130 + N/A N/A u13.5 -106 + N/A N/A N/A u52.5 -110  
Illinois Fighting Illini 329 Illinois
+145 +115 + N/A +124 + N/A N/A +120 + N/A N/A N/A +210  
Indiana Hoosiers 330 Indiana
-175 -145 + N/A -160 + N/A N/A -154 + N/A N/A N/A -258  

The Illinois Fighting Illini will take on the Indiana Hoosiers in this week's NCAAF action. Kickoff is set for 7:30 p.m. EDT at Memorial Stadium (Bloomington, IN) in Bloomington, Ind. The game will be broadcast live on NBC. Here's everything you need to know about Illinois vs. Indiana odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Indiana opened as a -5.5 point favorite over Illinois. The total is set at over/under 52.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Illinois Fighting Illini vs. Indiana Hoosiers Best Bet

This Big Ten matchup has a ton of College Football Playoff implications.

Over the last two seasons, Indiana and Illinois have been two of the best stories in college football as Curt Cignetti and Bret Bielema are two of the best coaches in America.

Although Indiana is the "lower" ranked team here, they are a 6.5-point home favorite against an Illinois team that has the most impressive win between the two, a 45-19 victory at Duke a few weeks back.

However, if we look beyond the score, Illinois was outgained in that one, relinquishing 9.1 yards per pass. If it weren't for generating 5 turnovers, Illinois wouldn't have cruised there.

Now, they take on Fernando Mendoza, a potential first-round pick. Mendoza conducted an impressive year at California in 2024 and has a 9-0 TD/INT ratio to start off the year.

I expect Indiana to be able to take care of the football here and put up some points. On the other side, this is an offensive line Indiana can take advantage of. Via College Football Data, Indiana is the No. 1 team in the nation with respect to front 7 havoc rate - if Indiana can jump out ahead of the home crowd, they should be able to pressure Illinois quarterback, Luke Altmyer all night.

Illinois vs. Indiana Best Bet: Indiana -6.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Illinois Fighting Illini vs. Indiana Hoosiers Game?

The Illinois Fighting Illini will take on the Indiana Hoosiers at 7:30 ET on Saturday, September 20th.

Where is the Illinois Fighting Illini vs. Indiana Hoosiers Game Being Played?

This game is going to be played at Memorial Stadium in Bloomington, Indiana.

How Can I Watch Indiana vs. Illinois?

You can watch Indiana vs. Illinois on NBC.

Can Illinois Beat Indiana?

Absolutely, the Illinois Fighting Illini can certainly pull off the upset this Saturday night in Bloomington, Indiana.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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