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Featured Last Updated Oct 10 2025, 12:09 PM

Ohio State vs. Illinois: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Ohio State vs. Illinois: Prediction, Odds, Best Bet

Image Credit: Samantha Madar via Imagn Images

OSU @ ILL Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Ohio State Buckeyes 183 Ohio State
-13.5 -110 -7.5 even + -7.5 even + -7.5 -102 + -7.5 even + -7.5 -120 + -7.5 -110 + -8.5 -105 + -7.5 even -7.5 -105 + -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 +7.5 -120 + +7.5 -120 + +7.5 -118 + +7.5 -120 + +7.5 -110 + +7.5 -110 + +8.5 -115 + +7.5 -120 +7.5 -120 + +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 o25.5 -110 + N/A o26.5 -108 + o26 -110 + N/A o26.5 -118 + o26.5 -110 + o25.5 -115 o24.5 -112 + o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 u25.5 -110 + N/A u26.5 -112 + u26 -110 + N/A u26.5 -105 + u26.5 -110 + u25.5 -105 u24.5 -117 + u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 -425 + -400 + -425 + -430 + -600 + -420 + N/A N/A -420 + -650  
Illinois Fighting Illini 184 Illinois
+525 +325 + +310 + +330 + +328 + +340 + +310 + N/A N/A +290 + +470  
Ohio State Buckeyes 183 Ohio State
-13.5 -110 -3.5 -110 + -3.5 -110 + -3.5 -110 + -3.5 -105 + -3.5 -115 + -3.5 -106 + -3.5 -125 + -3.5 -115 -3.5 -105 + -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 +3.5 -120 + +3.5 -115 + +3.5 -120 + +3.5 -125 + +3.5 -115 + +3.5 -118 + +3.5 -105 + +3.5 -115 +3.5 -124 + +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 o10.5 -110 + N/A o10.5 -110 + o10.5 -105 + o10.5 -115 + o10.5 +108 + o10.5 -105 + o10.5 -110 o9.5 -141 + o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 u10.5 -120 + N/A u10.5 -120 + u10.5 -125 + u10.5 -115 + u10.5 -138 + u10.5 -125 + u10.5 -120 u9.5 +110 + u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 -250 + -275 + -280 + -260 + -330 + -295 + N/A N/A -278 + -650  
Illinois Fighting Illini 184 Illinois
+525 +200 + +210 + +210 + +210 + +230 + +220 + N/A N/A +205 + +470  
Ohio State Buckeyes 183 Ohio State
-13.5 -110 N/A N/A -6.5 -122 + -7.5 +110 + N/A N/A N/A N/A N/A -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 N/A N/A +6.5 +102 + +7.5 -130 + N/A N/A N/A N/A N/A +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 N/A N/A o24.5 even + o23.5 -115 + N/A N/A o23.5 -130 + N/A N/A o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 N/A N/A u24.5 -120 + u23.5 -105 + N/A N/A u23.5 even + N/A N/A u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 N/A N/A -345 + N/A N/A N/A N/A N/A N/A -650  
Illinois Fighting Illini 184 Illinois
+525 N/A N/A +275 + N/A N/A N/A N/A N/A N/A +470  
Ohio State Buckeyes 183 Ohio State
-13.5 -110 N/A N/A -4.5 even + N/A N/A -4.5 -108 + -3.5 -130 + N/A N/A -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 N/A N/A +4.5 -130 + N/A N/A +4.5 -122 + +3.5 even + N/A N/A +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 o14 -115 + N/A o14.5 +110 + N/A N/A o14.5 -104 + o14.5 +110 + N/A N/A o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 u14 -115 + N/A u14.5 -140 + N/A N/A u14.5 -120 + u14.5 -140 + N/A N/A u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 -320 + N/A -330 + N/A N/A -340 + N/A N/A N/A -650  
Illinois Fighting Illini 184 Illinois
+525 +250 + N/A +240 + N/A N/A +250 + N/A N/A N/A +470  
Ohio State Buckeyes 183 Ohio State
-13.5 -110 N/A N/A -3.5 -125 + N/A N/A -3.5 -108 + -4.5 -105 + N/A N/A -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 N/A N/A +3.5 -105 + N/A N/A +3.5 -122 + +4.5 -125 + N/A N/A +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 o10 -120 + N/A o10.5 -115 + N/A N/A o10.5 -106 + o10.5 -120 + N/A N/A o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 u10 -110 + N/A u10.5 -115 + N/A N/A u10.5 -118 + u10.5 -110 + N/A N/A u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 -270 + N/A -315 + N/A N/A -295 + N/A N/A N/A -650  
Illinois Fighting Illini 184 Illinois
+525 +215 + N/A +230 + N/A N/A +215 + N/A N/A N/A +470  
Ohio State Buckeyes 183 Ohio State
-13.5 -110 -2.5 -115 + N/A -2.5 -130 + N/A N/A -2.5 -132 + -1.5 -115 + N/A N/A -14.5 -108  
Illinois Fighting Illini 184 Illinois
+13.5 -110 +2.5 -115 + N/A +2.5 even + N/A N/A +2.5 -100 + +1.5 -115 + N/A N/A +14.5 -112  
Ohio State Buckeyes 183 Ohio State
o50.5 -110 o13 -115 + N/A o13.5 -115 + N/A N/A o12.5 -124 + o10.5 -115 + N/A N/A o50.5 -112  
Illinois Fighting Illini 184 Illinois
u50.5 -110 u13 -115 + N/A u13.5 -115 + N/A N/A u12.5 -100 + u10.5 -115 + N/A N/A u50.5 -108  
Ohio State Buckeyes 183 Ohio State
-750 -210 + N/A -238 + N/A N/A -245 + N/A N/A N/A -650  
Illinois Fighting Illini 184 Illinois
+525 +165 + N/A +180 + N/A N/A +186 + N/A N/A N/A +470  

The Ohio State Buckeyes will take on the Illinois Fighting Illini in this week's NCAAF action. Kickoff is set for 12:00 p.m. EDT at Memorial Stadium (Champaign, IL) in Champaign, Ill. The game will be broadcast live on FOX. Here's everything you need to know about Ohio State vs. Illinois odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Ohio State Buckeyes opened as a -14.5 point favorite over Illinois. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Ohio State vs. Illinois Best Bet

Illinois is coming off a huge come-from-behind victory over USC to get back on track after a dismal 63-10 loss to Indiana a few weeks ago.

However, despite being at home, this is a tough spot for Illinois to get up for after such an emotional win.

This is a historic OSU defense that hasn't allowed double digits to a single opponent all year. Furthermore, the Buckeyes will have plenty of advantages on the perimeter with superstar Jeremiah Smith and Carnell Tate.

Ohio State vs. Illinois Best Bet: Ohio State -14.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Ohio State vs. Illinois Game?

The Ohio State Buckeyes will take on the Illinois Fighting Illini at 12:00 ET on Saturday, October 11th.

Where is the Ohio State Buckeyes vs. Illinois Fighting Illini Game Being Played?

This game is going to be played at Memorial Stadium in Champaign, Ill.

How Can I Watch Ohio State vs. Illinois?

You can watch OSU vs. Illinois on FOX.

Can Illinois Beat Ohio State?

It will require a Herculean effort from Illinois - however, the combination of home field advantage and their experience could go a long way towards a major upset in Champaign this Saturday.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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