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Last Updated Aug 30, 2021, 13:44 PM

Cardinals vs. Padres Predictions, Odds, Preview

May 16, 2021
Kevin Rogers
MLB Expert
VegasInsider.com

St. Louis Cardinals vs. San Diego Padres Predictions

Score Prediction - Cardinals 5, Padres 3

The Cardinals have yet to been swept in a series this season as they look to grab a win at San Diego tonight.

San Diego's lineup has been hit hard by COVID protocols with the likes of Fernando Tatis, Jr. and Eric Hosmer sidelined.

Kwang-hyun Kim has turned into a reliable starting pitcher for the Cardinals and should do enough to limit San Diego's offense and grab the win.

St. Louis Cardinals vs. San Diego Padres Best Bets

  • St. Louis +105

St. Louis Cardinals vs. San Diego Padres Game Odds

  • St. Louis +105
  • San Diego -130
  • St. Louis (+1.5) -200
  • San Diego (-1.5) +165
  • Over (7) -110
  • Under (7) -110

Odds per BetMGM - Subject to Change


Kwang-hyun Kim takes the mound tonight as the Cardinals try to avoid the sweep against the Padres at Petco Park. (AP)

St. Louis Cardinals vs. San Diego Padres Betting Analysis

  • Venue: Petco Park
  • Location: San Diego, California
  • TV-Time: ESPN - 7:00 p.m. ET

St. Louis Cardinals vs. San Diego Padres Current Form

The Cardinals remain atop the National League Central at 23-17 in spite of losing the last two games to the Padres.

St. Louis is 2-3 on its current road trip as the Cardinals own an 11-9 mark away from Busch Stadium.

The Padres are creeping closer to first place in the National League West as they sit only one half-game behind the Giants entering Sunday.

San Diego moved to 23-17 on the season after picking up its fifth win in the last six games on Saturday night.

St. Louis Cardinals vs. San Diego Padres Series History

The Padres knocked the Cardinals out of the playoffs last season by taking two of three games at Petco Park to advance to the National League Divisional Series.

San Diego has continued that run by beating St. Louis twice at Petco Park this weekend. The Padres edged the Cardinals on Friday night, 5-4 as -175 favorites.

On Saturday night, the Padres racked Cardinals' starter Adam Wainwright for six runs in the first three innings of a 13-3 rout. San Diego hit three home runs in the game, as the Padres broke above .500 at home, improving to 11-10.

Pitching Matchup

St. Louis: Kwang-hyun Kim (1-0, 2.74 ERA)

Kim has made five starts this season and the Cardinals have yet to lose with the southpaw on the mound.

The Korean hurler has allowed one earned run in each of his last four outings, while St. Louis owns an amazing 11-2 mark in his past 13 starts since 2020.

San Diego: Ryan Weathers (2-1, 0.81 ERA)

Weathers gets the job done whenever he takes the mound for the Padres, as the southpaw makes his fourth start on the season on Sunday.

The left-hander has given up only two earned runs in 22.1 innings of work, while making his first start since April 28 at Arizona.

The longest outing by Weathers this season was 5.2 innings in a 3-2 victory at Los Angeles on April 16, as he struck out six and allowed one hit.

Trends to Watch

St. Louis

  • 5-2 vs. LHP starters
  • 5-1 in last six series finales

San Diego

  • 2-4 in home series finales
  • Under 5-1 in last six vs. LHP starters


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