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NFL: Tampa Bay Buccaneers vs. Buffalo Bills: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Tampa Bay Buccaneers vs. Buffalo Bills: Prediction, Odds, Best Bet

Featured Image Credit: Nathan Ray Seebeck-Imagn Images

TB @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +3.5 -110 +3.5 -115 +2.5 -105 +3.5 -109 +3.5 -110 +3.5 -110 +1.5 -130 +3.5 -109 +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -3.5 -110 -3.5 -105 -2.5 -115 -3.5 -112 -3.5 -110 -3.5 -120 -1.5 even -3.5 -118 -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o23 -110 o21.5 -140 o22.5 -125 o22.5 -121 o23.5 +110 o22.5 -120 o22.5 -120 o23.5 -103 o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u23 -110 u21.5 +105 u22.5 +105 u22.5 +101 u23.5 -130 u22.5 even u22.5 -120 u23.5 -122 u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +180 +165 +142 +175 +190 N/A +110 +170 +245  
Buffalo Bills 456 Bills
-230 -225 -200 -170 -220 -240 N/A -155 -225 -305  
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +0.5 -115 +0.5 -130 +0.5 -125 N/A +1.5 -124 +0.5 -120 -0.5 -115 +1.5 -129 +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -0.5 -105 -0.5 even -0.5 -105 N/A -1.5 -100 -0.5 -110 +0.5 -115 -1.5 +104 -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o7.5 -120 o9.5 -105 o9.5 -108 N/A o9.5 -108 o9.5 -115 o8.5 -140 o9.5 -118 o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u7.5 even u9.5 -120 u9.5 -112 N/A u9.5 -114 u9.5 -115 u8.5 -105 u9.5 -107 u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +155 +145 +140 N/A +146 N/A -170 +138 +245  
Buffalo Bills 456 Bills
-230 -180 -185 -180 N/A -180 N/A +120 -175 -305  
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +3 -110 N/A +4.5 -110 N/A +2.5 +105 N/A +3.5 even +3.5 -125 +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -3 -110 N/A -4.5 -120 N/A -2.5 -125 N/A -3.5 -125 -3.5 +102 -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o22.5 -110 N/A o23.5 -102 N/A o21.5 -105 o22.5 -125 o22.5 -130 o21.5 -112 o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u22.5 -110 N/A u23.5 -118 N/A u21.5 -115 u22.5 -105 u22.5 -110 u21.5 -112 u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +135 N/A +235 N/A +152 N/A +175 +160 +245  
Buffalo Bills 456 Bills
-230 -160 N/A -290 N/A -196 N/A -270 -200 -305  
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 N/A N/A +2.5 -115 N/A +2.5 -102 +2.5 -105 +1.5 even N/A +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 N/A N/A -2.5 -115 N/A -2.5 -124 -2.5 -125 -1.5 -130 N/A -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o13.5 -105 N/A o13.5 -105 N/A o26.5 -120 o13.5 -105 o14.5 +115 N/A o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u13.5 -115 N/A u13.5 -125 N/A u26.5 -108 u13.5 -125 u14.5 -170 N/A u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +165 N/A +140 N/A +164 N/A +150 N/A +245  
Buffalo Bills 456 Bills
-230 -200 N/A -180 N/A -205 N/A -200 N/A -305  
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 N/A N/A +2.5 -108 N/A +1.5 -124 +0.5 -110 +1.5 +105 N/A +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 N/A N/A -2.5 -112 N/A -1.5 +102 -0.5 -120 -1.5 -140 N/A -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o9.5 -115 N/A o9.5 -130 N/A o16.5 +280 o9.5 -120 o8.5 -145 N/A o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u9.5 -105 N/A u9.5 even N/A u16.5 -410 u9.5 -110 u8.5 even N/A u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +145 N/A +170 N/A +142 N/A +175 N/A +245  
Buffalo Bills 456 Bills
-230 -170 N/A -220 N/A -178 N/A -270 N/A -305  
Final
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +0.5 -120 N/A +1.5 -120 N/A +1.5 -120 +1.5 -115 +1.5 -115 N/A +6.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -0.5 even N/A -1.5 -110 N/A -1.5 -102 -1.5 -115 -1.5 -115 N/A -6.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o13 -110 N/A o13.5 +102 N/A o12.5 -114 o13.5 even o12.5 -140 N/A o46.5 -110  
Buffalo Bills 456 Bills
u49.5 -110 u13 -110 N/A u13.5 -125 N/A u12.5 -108 u13.5 -130 u12.5 -105 N/A u46.5 -110  
Final
Tampa Bay Buccaneers 455 Buccaneers
+190 +120 N/A +135 N/A +132 N/A +135 N/A +245  
Buffalo Bills 456 Bills
-230 -140 N/A -175 N/A -158 N/A -190 N/A -305  

The Buccaneers will take on the Bills in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on CBS. Here's everything you need to know about Buccaneers vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -5.5 point favorite over Buccaneers. The total is set at over/under 47.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 1/1/26

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Tampa Bay Buccaneers vs. Buffalo Bills Best Bet

Tampa Bay’s offense, averaging 328 yards per game, has the tools to stay competitive against Buffalo. Buffalo's run defense has struggled this season, allowing 147 rushing yards per game, which ranks 3rd worst in the league. This vulnerability gives Tampa Bay a clear path to control the ground game, sustain drives, and limit Buffalo’s possessions. By mixing runs and short passes, Tampa Bay can keep the game close.

With the spread at +6, Tampa Bay's ability to exploit Buffalo’s run‑defense weaknesses and generate consistent offensive drives gives them a realistic chance to cover.

Tampa Bay Buccaneers vs. Buffalo Bills Best Bet: Tampa Bay Buccaneers +6 (-112)

(Pick from Dylan Wilkerson)

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What Time is the Tampa Bay Buccaneers vs. Buffalo Bills Game?

The Tampa Bay Buccaneers vs. Buffalo Bills game is at 1:00 PM ET on Sunday, November 16th.

Where is the Tampa Bay Buccaneers vs. Buffalo Bills Game Being Played?

This game will be played at Highmark Stadium in Orchard Park, N.Y..

How Can I Watch Tampa Bay Buccaneers vs. Buffalo Bills?

You can watch Tampa Bay Buccaneers vs. Buffalo Bills on CBS.

Can the Bucs Beat the Bills?

Of course! The Bucs are a 5.5 point underdog, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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