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Featured Last Updated Nov 14 2025, 10:33 AM

NFL: Tampa Bay Buccaneers vs. Buffalo Bills: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: Tampa Bay Buccaneers vs. Buffalo Bills: Prediction, Odds, Best Bet

Featured Image Credit: Nathan Ray Seebeck-Imagn Images

TB @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +3 -105 + +3.5 -115 + +3.5 -118 + +3.5 -118 + +3.5 -115 + +4.5 -110 + +3.5 -120 +3.5 -120 + +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -3 -115 + -3.5 -105 + -3.5 -102 + -3.5 -103 + -3.5 -105 + -4.5 -110 + -3.5 even -3.5 -107 + -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o23.5 -115 + o23.5 -125 + o23.5 -105 + o23.5 -115 + o23.5 -110 + o23.5 -115 + o22.5 -135 o23.5 -120 + o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u23.5 -105 + u23.5 +105 + u23.5 -115 + u23.5 -106 + u23.5 -110 + u23.5 -105 + u22.5 +110 u23.5 -105 + u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +155 + +165 + +160 + +150 + +166 + N/A +165 +160 + +210  
Buffalo Bills 456 Bills
-230 -185 + -200 + -192 + -190 + -205 + N/A -200 -205 + -258  
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +0.5 -130 + +0.5 -125 + +0.5 -135 + N/A +1.5 -130 + +0.5 -120 + +1.5 -130 +1.5 -136 + +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -0.5 +110 + -0.5 -102 + -0.5 +114 + N/A -1.5 +108 + -0.5 even + -1.5 +110 -1.5 +110 + -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o9.5 -110 + o9.5 -130 + o8.5 -112 + N/A o9.5 -118 + o9.5 -110 + o8.5 -135 o9.5 -129 + o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u9.5 -110 + u9.5 even + u8.5 -108 + N/A u9.5 -104 + u9.5 -110 + u8.5 even u9.5 +104 + u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +125 + +130 + +124 + N/A +136 + N/A +130 +125 + +210  
Buffalo Bills 456 Bills
-230 -150 + -165 + -148 + N/A -168 + N/A -175 -157 + -258  
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +3 -110 + N/A +3.5 -115 + N/A +2.5 -110 + N/A N/A +2.5 -106 + +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -3 -110 + N/A -3.5 -105 + N/A -2.5 -110 + N/A N/A -2.5 -118 + -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o22.5 -110 + N/A o21.5 -115 + N/A o22.5 -110 + N/A N/A o22.5 -117 + o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u22.5 -110 + N/A u21.5 -105 + N/A u22.5 -110 + N/A N/A u22.5 -107 + u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +130 + N/A +164 + N/A +146 + N/A N/A +143 + +210  
Buffalo Bills 456 Bills
-230 -155 + N/A -198 + N/A -172 + N/A N/A -180 + -258  
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 N/A N/A +2.5 -108 + N/A +2.5 -108 + +3.5 -110 + N/A N/A +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 N/A N/A -2.5 -112 + N/A -2.5 -112 + -3.5 -120 + N/A N/A -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o14 -110 + N/A o14.5 +102 + N/A o14.5 +104 + o14.5 even + N/A N/A o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u14 -110 + N/A u14.5 -122 + N/A u14.5 -126 + u14.5 -130 + N/A N/A u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +150 + N/A +145 + N/A +148 + N/A N/A N/A +210  
Buffalo Bills 456 Bills
-230 -180 + N/A -175 + N/A -184 + N/A N/A N/A -258  
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 N/A N/A +0.5 -112 + N/A +1.5 -130 + N/A N/A N/A +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 N/A N/A -0.5 -108 + N/A -1.5 +108 + N/A N/A N/A -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o9.5 -115 + N/A o9.5 -110 + N/A o9.5 -114 + N/A N/A N/A o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u9.5 -105 + N/A u9.5 -110 + N/A u9.5 -108 + N/A N/A N/A u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +135 + N/A +145 + N/A +136 + N/A N/A N/A +210  
Buffalo Bills 456 Bills
-230 -160 + N/A -175 + N/A -168 + N/A N/A N/A -258  
Tampa Bay Buccaneers 455 Buccaneers
+5.5 -110 +0.5 -120 + N/A +1.5 -110 + N/A +1.5 -130 + N/A N/A N/A +5.5 -110  
Buffalo Bills 456 Bills
-5.5 -110 -0.5 even + N/A -1.5 -110 + N/A -1.5 +108 + N/A N/A N/A -5.5 -110  
Tampa Bay Buccaneers 455 Buccaneers
o49.5 -110 o13 -110 + N/A o12.5 -120 + N/A o12.5 -128 + N/A N/A N/A o46.5 -108  
Buffalo Bills 456 Bills
u49.5 -110 u13 -110 + N/A u12.5 even + N/A u12.5 +104 + N/A N/A N/A u46.5 -112  
Tampa Bay Buccaneers 455 Buccaneers
+190 +120 + N/A +145 + N/A +122 + N/A N/A N/A +210  
Buffalo Bills 456 Bills
-230 -140 + N/A -175 + N/A -150 + N/A N/A N/A -258  

The Buccaneers will take on the Bills in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Highmark Stadium in Orchard Park, N.Y. The game will be broadcast live on CBS. Here's everything you need to know about Buccaneers vs. Bills odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -5.5 point favorite over Buccaneers. The total is set at over/under 47.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 11/14/25

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Tampa Bay Buccaneers vs. Buffalo Bills Best Bet

Tampa Bay’s offense, averaging 328 yards per game, has the tools to stay competitive against Buffalo. Buffalo's run defense has struggled this season, allowing 147 rushing yards per game, which ranks 3rd worst in the league. This vulnerability gives Tampa Bay a clear path to control the ground game, sustain drives, and limit Buffalo’s possessions. By mixing runs and short passes, Tampa Bay can keep the game close.

With the spread at +6, Tampa Bay's ability to exploit Buffalo’s run‑defense weaknesses and generate consistent offensive drives gives them a realistic chance to cover.

Tampa Bay Buccaneers vs. Buffalo Bills Best Bet: Tampa Bay Buccaneers +6 (-112)

(Pick from Dylan Wilkerson)

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What Time is the Tampa Bay Buccaneers vs. Buffalo Bills Game?

The Tampa Bay Buccaneers vs. Buffalo Bills game is at 1:00 PM ET on Sunday, November 16th.

Where is the Tampa Bay Buccaneers vs. Buffalo Bills Game Being Played?

This game will be played at Highmark Stadium in Orchard Park, N.Y..

How Can I Watch Tampa Bay Buccaneers vs. Buffalo Bills?

You can watch Tampa Bay Buccaneers vs. Buffalo Bills on CBS.

Can the Bucs Beat the Bills?

Of course! The Bucs are a 5.5 point underdog, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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