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Broncos vs. 49ers Predictions: Low-Scoring Affair

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Broncos vs. 49ers Predictions: Low-Scoring Affair

The Denver Broncos will take on the San Francisco 49ers in this week's NFL action. Kickoff is set for 4:25 PM EST at Levi's Stadium in Santa Clara, CA. The game will be broadcast live on CBS. Here's everything you need to know about Broncos vs. 49ers odds, the latest college football spreads, college football over/unders and more.

DEN @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Denver Broncos 271 Broncos
+2.5 -110 +2.5 -110 +2.5 -108 +1.5 -110 +2.5 -125 +1.5 -110 +1.5 -115 +1.5 -105 +1.5 -109 +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 -2.5 -110 -2.5 -110 -1.5 -110 -2.5 +104 -1.5 -110 -1.5 -115 -1.5 -115 -1.5 -114 -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o23.5 -115 o23.5 -112 o23.5 -118 o23.5 -115 o23.5 -120 o23.5 -120 o24.5 +110 o23.5 -124 o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u23.5 -105 u23.5 -105 u23.5 -102 u23.5 -105 u23.5 -100 u23.5 -110 u24.5 -150 u23.5 even u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 +125 +130 +124 +112 +126 N/A +130 +120 +140  
San Francisco 49ers 272 49ers
-135 -150 -160 -148 -134 -154 N/A -155 -148 -166  
Final
Denver Broncos 271 Broncos
+2.5 -110 +0.5 -150 +0.5 -150 +0.5 -148 N/A +1.5 -156 +0.5 -155 +0.5 -145 +1.5 -157 +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 -0.5 +125 -0.5 +115 -0.5 +124 N/A -1.5 +128 -0.5 +120 -0.5 +120 -1.5 +128 -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o9.5 -120 o9.5 -118 o9.5 -118 N/A o9.5 -118 o9.5 -120 o9.5 -120 o9.5 -130 o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u9.5 even u9.5 -108 u9.5 -102 N/A u9.5 -104 u9.5 -110 u9.5 -110 u9.5 +108 u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 +105 +110 +105 N/A +112 N/A +105 +106 +140  
San Francisco 49ers 272 49ers
-135 -125 -135 -125 N/A -138 N/A -140 -130 -166  
Final
Denver Broncos 271 Broncos
+2.5 -110 +0.5 -120 N/A +1.5 -120 N/A +1.5 -130 +0.5 -115 +1.5 -125 +1.5 -121 +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 -0.5 even N/A -1.5 -110 N/A -1.5 +110 -0.5 -115 -1.5 +105 -1.5 -104 -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o23.5 -120 N/A o24.5 +105 N/A o23.5 -115 o23.5 -120 o24.5 -105 o23.5 -108 o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u23.5 even N/A u24.5 -125 N/A u23.5 -105 u23.5 -110 u24.5 -125 u23.5 -115 u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 even N/A +114 N/A +106 N/A +110 +112 +140  
San Francisco 49ers 272 49ers
-135 -120 N/A -145 N/A -124 N/A -130 -136 -166  
Final
Denver Broncos 271 Broncos
+2.5 -110 N/A N/A +0.5 -110 N/A +1.5 -124 +0.5 -120 +0.5 -115 N/A +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 N/A N/A -0.5 -120 N/A -1.5 +102 -0.5 -110 -0.5 -105 N/A -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o13.5 -120 N/A o13.5 -120 N/A o14.5 +104 o13.5 -125 o13.5 -135 N/A o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u13.5 -110 N/A u13.5 -110 N/A u14.5 -126 u13.5 -105 u13.5 even N/A u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 +122 N/A +120 N/A +122 N/A +115 N/A +140  
San Francisco 49ers 272 49ers
-135 -155 N/A -154 N/A -150 N/A -150 N/A -166  
Final
Denver Broncos 271 Broncos
+2.5 -110 N/A N/A +0.5 -140 N/A +1.5 -156 +0.5 -150 +0.5 -140 N/A +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 N/A N/A -0.5 +110 N/A -1.5 +128 -0.5 +115 -0.5 +115 N/A -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o9.5 -145 N/A o9.5 -145 N/A o9.5 -128 o9.5 -140 o9.5 -150 N/A o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u9.5 +115 N/A u9.5 +114 N/A u9.5 +106 u9.5 +110 u9.5 +110 N/A u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 +105 N/A +110 N/A +108 N/A +105 N/A +140  
San Francisco 49ers 272 49ers
-135 -135 N/A -140 N/A -132 N/A -140 N/A -166  
Final
Denver Broncos 271 Broncos
+2.5 -110 +0.5 -130 N/A +0.5 -130 N/A +1.5 -164 +0.5 -140 +0.5 -135 N/A +3 -115  
San Francisco 49ers 272 49ers
-2.5 -110 -0.5 even N/A -0.5 even N/A -1.5 +134 -0.5 +110 -0.5 +110 N/A -3 -105  
Final
Denver Broncos 271 Broncos
o46.5 -110 o13.5 -130 N/A o14.5 even N/A o13.5 -114 o13.5 -120 o13.5 -120 N/A o48.5 -105  
San Francisco 49ers 272 49ers
u46.5 -110 u13.5 even N/A u14.5 -130 N/A u13.5 -108 u13.5 -110 u13.5 -110 N/A u48.5 -115  
Final
Denver Broncos 271 Broncos
+114 even N/A even N/A -105 N/A even N/A +140  
San Francisco 49ers 272 49ers
-135 -130 N/A -130 N/A -115 N/A -130 N/A -166  

The San Francisco 49ers opened as a -3 point favorite to Denver. The total is set at over/under 47.5 total points scored by both teams combined.

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Updated on 10/12/26

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Broncos vs. 49ers Prediction

Both of these teams play very slow. The Broncos are averaging 61 offensive snaps per game, and the 49ers average 57.7 offensive snaps per game. This sets up a low-scoring environment for this matchup.

The Broncos have a 7.41% turnover worthy play rate, indicating that when they do have the ball they are susceptible to giving it up at anytime, killing drives.

Both teams are on the higher end of Nick Giffen's luck rankings, indicating that scoring recession may be inbound.

Updated on 10/12/26

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Broncos vs. 49ers Prediction: Denver Broncos @ San Francisco 49ers u48.5 (-110)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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