Broncos vs. 49ers Predictions: Low-Scoring Affair
Dylan Wilkerson Sports Betting Expert
The Denver Broncos will take on the San Francisco 49ers in this week's NFL action. Kickoff is set for 4:25 PM EST at Levi's Stadium in Santa Clara, CA. The game will be broadcast live on CBS. Here's everything you need to know about Broncos vs. 49ers odds, the latest college football spreads, college football over/unders and more.
DEN @ SF Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  › |  | ||
 271 Broncos | +2.5 -110 | +2.5 even | +2.5 -102 | +3 -120 | +2.5 -102 | +2.5 -102 | +3 -115 | +2.5 -105 | +2.5 -105 | +3 -120 | |
 272 49ers | -2.5 -110 | -2.5 -120 | -2.5 -118 | -3 even | -2.5 -120 | -2.5 -120 | -3 -105 | -2.5 -115 | -2.5 -115 | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o47.5 -115 | o48 -108 | o47.5 -110 | o47.5 -118 | o47.5 -112 | o48 -110 | o48.5 -110 | o47.5 -113 | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u47.5 -105 | u48 -110 | u47.5 -110 | u47.5 -103 | u47.5 -108 | u48 -110 | u48.5 -110 | u47.5 -108 | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | +125 | +125 | +124 | +125 | +126 | +125 | +120 | +114 | +124 | |
| 272 49ers | -135 | -150 | -150 | -148 | -148 | -148 | -145 | -145 | -137 | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | +0.5 -105 | +0.5 -108 | +0.5 -105 | +1.5 -117 | +1.5 -120 | +0.5 -110 | +1.5 -120 | +1.5 -127 | +3 -120 | |
| 272 49ers | -2.5 -110 | -0.5 -115 | -0.5 -112 | -0.5 -115 | -1.5 -104 | -1.5 -100 | -0.5 -120 | -1.5 even | -1.5 +102 | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o23.5 -110 | o23.5 -110 | o23.5 -102 | o23.5 -106 | o23.5 -120 | o23.5 -120 | o24.5 +110 | o23.5 -118 | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u23.5 -110 | u23.5 -108 | u23.5 -118 | u23.5 -114 | u23.5 -100 | u23.5 -110 | u24.5 -150 | u23.5 -104 | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | +115 | +115 | +114 | +115 | +112 | N/A | +115 | +106 | +124 | |
| 272 49ers | -135 | -135 | -135 | -135 | -137 | -136 | N/A | -140 | -130 | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | +0.5 -150 | +0.5 -160 | +0.5 -155 | N/A | +1.5 -166 | +0.5 -160 | +0.5 -155 | +1.5 -165 | +3 -120 | |
| 272 49ers | -2.5 -110 | -0.5 +125 | -0.5 +125 | -0.5 +130 | N/A | -1.5 +136 | -0.5 +120 | -0.5 +125 | -1.5 +132 | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o9.5 -115 | o9.5 -120 | o9.5 -118 | N/A | o9.5 -118 | o9.5 -120 | o9.5 -120 | o9.5 -130 | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u9.5 -105 | u9.5 -108 | u9.5 -102 | N/A | u9.5 -104 | u9.5 -110 | u9.5 -110 | u9.5 +107 | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | +110 | even | even | N/A | +104 | N/A | even | even | +124 | |
| 272 49ers | -135 | -130 | -130 | -120 | N/A | -128 | N/A | -130 | -125 | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | +0.5 -120 | N/A | +1.5 -125 | N/A | +1.5 -125 | +0.5 -115 | N/A | +1.5 -122 | +3 -120 | |
| 272 49ers | -2.5 -110 | -0.5 even | N/A | -1.5 -105 | N/A | -1.5 +105 | -0.5 -115 | N/A | -1.5 +102 | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o23.5 -110 | N/A | o24.5 even | N/A | o23.5 -110 | o23.5 -115 | N/A | o23.5 -105 | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u23.5 -110 | N/A | u24.5 -120 | N/A | u23.5 -110 | u23.5 -115 | N/A | u23.5 -118 | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | even | N/A | +114 | N/A | +112 | N/A | N/A | +106 | +124 | |
| 272 49ers | -135 | -120 | N/A | -145 | N/A | -130 | N/A | N/A | -132 | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | N/A | N/A | +0.5 -120 | N/A | +1.5 -134 | +0.5 -120 | N/A | N/A | +3 -120 | |
| 272 49ers | -2.5 -110 | N/A | N/A | -0.5 -110 | N/A | -1.5 +110 | -0.5 -110 | N/A | N/A | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o13.5 -105 | N/A | o13.5 even | N/A | o14.5 +106 | o13.5 -115 | N/A | N/A | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u13.5 -125 | N/A | u13.5 -130 | N/A | u14.5 -128 | u13.5 -115 | N/A | N/A | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | +110 | N/A | +110 | N/A | +114 | N/A | N/A | N/A | +124 | |
| 272 49ers | -135 | -140 | N/A | -140 | N/A | -140 | N/A | N/A | N/A | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | N/A | N/A | +0.5 -140 | N/A | +1.5 -154 | +0.5 -145 | N/A | N/A | +3 -120 | |
| 272 49ers | -2.5 -110 | N/A | N/A | -0.5 +110 | N/A | -1.5 +126 | -0.5 +110 | N/A | N/A | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o9.5 -120 | N/A | o9.5 -140 | N/A | o9.5 -126 | o9.5 -130 | N/A | N/A | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u9.5 -110 | N/A | u9.5 +110 | N/A | u9.5 +104 | u9.5 even | N/A | N/A | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | +110 | N/A | +105 | N/A | +112 | N/A | N/A | N/A | +124 | |
| 272 49ers | -135 | -140 | N/A | -135 | N/A | -138 | N/A | N/A | N/A | -148 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +2.5 -110 | +0.5 -140 | N/A | +0.5 -125 | N/A | +1.5 -156 | +0.5 -130 | N/A | N/A | +3 -120 | |
| 272 49ers | -2.5 -110 | -0.5 +110 | N/A | -0.5 -105 | N/A | -1.5 +128 | -0.5 even | N/A | N/A | -3 even | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | o46.5 -110 | o13.5 -105 | N/A | o13.5 -125 | N/A | o13.5 -112 | o13.5 -120 | N/A | N/A | o47.5 -110 | |
| 272 49ers | u46.5 -110 | u13.5 -125 | N/A | u13.5 -105 | N/A | u13.5 -110 | u13.5 -110 | N/A | N/A | u47.5 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 271 Broncos | +114 | -105 | N/A | +105 | N/A | -102 | N/A | N/A | N/A | +124 | |
| 272 49ers | -135 | -125 | N/A | -135 | N/A | -120 | N/A | N/A | N/A | -148 | |
The San Francisco 49ers opened as a -3 point favorite to Denver. The total is set at over/under 47.5 total points scored by both teams combined.
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Updated on 10/1/26
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Broncos vs. 49ers Prediction
Both of these teams play very slow. The Broncos are averaging 61 offensive snaps per game, and the 49ers average 57.7 offensive snaps per game. This sets up a low-scoring environment for this matchup.
The Broncos have a 7.41% turnover worthy play rate, indicating that when they do have the ball they are susceptible to giving it up at anytime, killing drives.
Both teams are on the higher end of Nick Giffen's luck rankings, indicating that scoring recession may be inbound.
Updated on 10/1/26
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Broncos vs. 49ers Prediction: Denver Broncos @ San Francisco 49ers u48.5 (-110)
(Pick from Dylan Wilkerson)
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