Colts vs. Commanders Predictions: High-Scoring Affair in London

Dylan Wilkerson Sports Betting Expert

14 minute read

The Indianapolis Colts will take on the Washington Commanders in this week's NFL action. Kickoff is set for 9:30 AM EST at Tottenham Hotspur Stadium in London, England. The game will be broadcast live on NFL Network. Here's everything you need to know about Colts vs. Commanders odds, the latest college football spreads, college football over/unders and more.

Colts @ Commanders Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	FanDuel	HardRock	Fanatics	RiversCasino	Consensus
Final	Open	›	›	›	›	›	›	›	›
251 Colts	+1.5 -122	-4.5 -120	-5 -108	-4.5 -118	-5 -110	-4.5 -120	-5.5 -110	-5 -110	-5 -109	-4.5 -118
252 Commanders	-1.5 +102	+4.5 even	+5 -102	+4.5 -102	+5 -110	+4.5 -110	+5.5 -110	+5 -110	+5 -112	+4.5 -102
Matchup
Final	Open	›	›	›	›	›	›	›	›
251 Colts	o48.5 -110	o46.5 -110	o46.5 -112	o46.5 -108	o46.5 -112	o46.5 -118	o46.5 -115	o46.5 -115	o47 -114	o46.5 -108
252 Commanders	u48.5 -110	u46.5 -110	u46.5 -105	u46.5 -112	u46.5 -108	u46.5 -104	u46.5 -105	u46.5 -105	u47 -107	u46.5 -112
Matchup
Final	Open	›	›	›	›	›	›	›	›
251 Colts	-110	-225	-225	-230	-230	-260	-230	-235	-215	-230
252 Commanders	-110	+185	+190	+190	+188	+196	+190	+190	+175	+190
Matchup

The Indianapolis Colts opened as a -3.5 point favorite to Washington. The total is set at over/under 48.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the Polymarket promo code!

Updated on 10/11/26

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Colts vs. Commanders Prediction

These defenses are two of the worst in the league. PFF ranks the Colts as the 31st defense and the Commanders as the 24th. In addition to this, these two teams play relatively quick on offense. The Commanders average nearly 72 offensive snaps per game and have nearly a 7% big time throw rate.

This will be a game with a lot of plays and a high chance of big-chunk offensive plays. This should be a high scoring game.

Updated on 10/11/26

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Colts vs. Commanders Prediction: Colts vs. Commanders Over 48

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson