Patriots vs Texans Odds
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| Pos | Player | Status |
| OL | Riley Reiff (Knee) | Questionable |
| WR | DeVante Parker (Knee) | Questionable |
| OL | Trent Brown (Ankle/Hand) | Questionable |
| RB | Ezekiel Elliott (Thigh) | Questionable |
| LB | Matthew Judon (Bicep) | Out |
| WR | JuJu Smith-Schuster (Ankle) | Questionable |
| LB | Raekwon McMillan (Achilles) | Out |
| DL | Deatrich Wise Jr. (Illness) | Questionable |
| WR | Kendrick Bourne (Knee) | Out |
| LB | Chris Board (Back) | Questionable |
| DL | Daniel Ekuale (Bicep) | Out |
| OL | Calvin Anderson (Illness) | Out |
| RB | Rhamondre Stevenson (Ankle) | Questionable |
| WR | Tre Nixon (Shoulder) | Out |
| DL | Christian Barmore (Shoulder) | Questionable |
| CB | Shaun Wade (Illness) | Questionable |
| OT | Tyrone Wheatley Jr. (Knee) | Out |
| WR | Kayshon Boutte (Shoulder) | Questionable |
| DB | Marcus Jones (Shoulder) | Out |
| CB | Christian Gonzalez (Shoulder) | Out |
| WR | Demario Douglas (Concussion) | Questionable |
| OL | Sidy Sow (Ankle) | Questionable |
| CB | Isaiah Bolden (Head) | Out |
| Pos | Player | Status |
| S | Eric Murray (Knee) | Out |
| DT | Hassan Ridgeway (Achilles) | Out |
| K | Ka'imi Fairbairn (Quad) | Out |
| S | M.J. Stewart (Shoulder) | Out |
| TE | Dalton Schultz (Hamstring) | Questionable |
| C | Scott Quessenberry (Knee) | Out |
| OT | Tytus Howard (Knee) | Out |
| S | Grayland Arnold (Calf) | Out |
| C | Kendrick Green (Knee) | Out |
| G | Kenyon Green (Shoulder) | Out |
| TE | Teagan Quitoriano (Groin) | Out |
| FB | Troy Hairston (Back) | Out |
| G | Jarrett Patterson (Ankle) | Out |
| WR | Tank Dell (Leg) | Out |
| DE | Dylan Horton (Personal) | Out |
| WR | Jesse Matthews (Knee) | Out |
| OT | Kilian Zierer (Ankle) | Out |
| C | DJ Scaife (Leg) | Out |
| Date | Team | Opp | Close | Result | ATS/OU |
| Oct 10, 2021 | Patriots | @Texans | -8
/ 39 | Won 25-22 | Lost /
Over |
| Nov 22, 2020 | Patriots | @Texans | -2.5
/ 49.5 | Lost 20-27 | Lost /
Under |
| Dec 1, 2019 | Patriots | @Texans | -3.5
/ 47.5 | Lost 22-28 | Lost /
Over |
| Sep 9, 2018 | Patriots | Texans | -6
/ 49 | Won 27-20 | Won /
Under |
| Sep 24, 2017 | Patriots | Texans | -13.5
/ 44.5 | Won 36-33 | Lost /
Over |
| Jan 14, 2017 | Patriots | Texans | -15.5
/ 44.5 | Won 34-16 | Won /
Over |
| Sep 22, 2016 | Patriots | Texans | -1
/ 39.5 | Won 27-0 | Won /
Under |
| Dec 13, 2015 | Patriots | @Texans | -4.5
/ 46.5 | Won 27-6 | Won /
Under |
| Dec 1, 2013 | Patriots | @Texans | -7
/ 49 | Won 34-31 | Lost /
Over |
| Jan 13, 2013 | Patriots | Texans | +9.5
/ 50.5 | Won 41-28 | Won /
Over |
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467 Patriots 
468 Texans 