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Featured Last Updated Jan 6 2026, 9:09 AM

NFL Wild Card Round: San Francisco 49ers vs. Philadelphia Eagles Prediction, Odds, Preview

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL Wild Card Round: San Francisco 49ers vs. Philadelphia Eagles Prediction, Odds, Preview

Featured Image Credit: Gregory Fisher via Imagn Images

SF @ PHI Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 381 49ers
+3.5 -115 +3.5 -115 + +3.5 -118 + +3.5 -122 + +3.5 -120 + +3.5 -125 + +3.5 -115 + +3.5 -120 + +2.5 even + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 -3.5 -105 + -3.5 -102 + -3.5 +102 + -3.5 -102 + -3.5 +105 + -3.5 -105 + -3.5 even + -2.5 -125 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o22.5 -115 + o22.5 -110 + o22.5 -115 + o22.5 -110 + o22.5 -110 + o22.5 -110 + o22.5 -110 + o23.5 +102 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u22.5 -105 + u22.5 -110 + u22.5 -105 + u22.5 -109 + u22.5 -110 + u22.5 -110 + u22.5 -110 + u23.5 -125 + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +160 + +155 + +154 + +158 + +156 + N/A +160 + +155 + +195  
Philadelphia Eagles 382 Eagles
-192 -190 + -190 + -185 + -193 + -190 + N/A -190 + -195 + -238  
San Francisco 49ers 381 49ers
+3.5 -115 +0.5 -120 + +0.5 -130 + +0.5 -122 + N/A +1.5 -144 + +0.5 -125 + +1.5 -130 + +1.5 -141 + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 -0.5 even + -0.5 even + -0.5 +102 + N/A -1.5 +118 + -0.5 +105 + -1.5 +110 + -1.5 +114 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o9.5 even + o9.5 -105 + o8.5 -112 + N/A o7.5 -108 + o7.5 -105 + o8.5 -115 + o8.5 -114 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u9.5 -120 + u9.5 -120 + u8.5 -108 + N/A u7.5 -112 + u7.5 -115 + u8.5 -115 + u8.5 -108 + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +140 + +130 + +140 + N/A +122 + N/A +130 + +125 + +195  
Philadelphia Eagles 382 Eagles
-192 -165 + -160 + -166 + N/A -150 + N/A -170 + -157 + -238  
San Francisco 49ers 381 49ers
+3.5 -115 +1.5 -110 + N/A +2.5 -105 + N/A +2.5 -110 + N/A N/A +2.5 -114 + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 -1.5 -110 + N/A -2.5 -125 + N/A -2.5 -110 + N/A N/A -2.5 -109 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o21.5 -110 + N/A o21.5 -112 + N/A o21.5 -100 + N/A N/A o21.5 -112 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u21.5 -110 + N/A u21.5 -108 + N/A u21.5 -120 + N/A N/A u21.5 -112 + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +130 + N/A +145 + N/A +138 + N/A N/A +135 + +195  
Philadelphia Eagles 382 Eagles
-192 -155 + N/A -188 + N/A -162 + N/A N/A -167 + -238  
San Francisco 49ers 381 49ers
+3.5 -115 N/A N/A +0.5 -110 + N/A +2.5 -110 + N/A N/A +1.5 -114 + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 N/A N/A -0.5 -120 + N/A -2.5 -110 + N/A N/A -1.5 -109 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o13.5 -105 + N/A o13.5 -105 + N/A o13.5 -110 + N/A N/A o13.5 -114 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u13.5 -115 + N/A u13.5 -125 + N/A u13.5 -110 + N/A N/A u13.5 -109 + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +150 + N/A +130 + N/A +144 + N/A N/A +140 + +195  
Philadelphia Eagles 382 Eagles
-192 -180 + N/A -166 + N/A -178 + N/A N/A -177 + -238  
San Francisco 49ers 381 49ers
+3.5 -115 N/A N/A +0.5 -125 + N/A +1.5 -138 + N/A N/A +1.5 -143 + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 N/A N/A -0.5 -105 + N/A -1.5 +114 + N/A N/A -1.5 +117 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o9.5 -110 + N/A o9.5 -115 + N/A o7.5 -110 + N/A N/A o8.5 -113 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u9.5 -110 + N/A u9.5 -115 + N/A u7.5 -110 + N/A N/A u8.5 -110 + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +135 + N/A +135 + N/A +128 + N/A N/A +123 + +195  
Philadelphia Eagles 382 Eagles
-192 -160 + N/A -175 + N/A -158 + N/A N/A -152 + -238  
San Francisco 49ers 381 49ers
+3.5 -115 +0.5 -125 + N/A +0.5 -110 + N/A +1.5 -134 + N/A N/A +1.5 -130 + +4.5 -112  
Philadelphia Eagles 382 Eagles
-3.5 -105 -0.5 +105 + N/A -0.5 -120 + N/A -1.5 +110 + N/A N/A -1.5 +106 + -4.5 -108  
San Francisco 49ers 381 49ers
o46.5 -110 o13 -105 + N/A o12.5 -125 + N/A o12.5 -110 + N/A N/A o12.5 -124 + o44.5 -110  
Philadelphia Eagles 382 Eagles
u46.5 -110 u13 -115 + N/A u12.5 -105 + N/A u12.5 -110 + N/A N/A u12.5 even + u44.5 -110  
San Francisco 49ers 381 49ers
+160 +115 + N/A +124 + N/A +118 + N/A N/A +120 + +195  
Philadelphia Eagles 382 Eagles
-192 -135 + N/A -160 + N/A -144 + N/A N/A -150 + -238  

The 49ers will take on the Eagles in this week's NFL action. Kickoff is set for 4:30 p.m. EST at Lincoln Financial Field in Philadelphia, Pa. The game will be broadcast live on FOX. Here's everything you need to know about 49ers vs. Eagles odds, the latest NFL spreads, NFL over/unders and more.

The Eagles opened as a -3.5 point favorite over the 49ers. The total is set at over/under 46 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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San Francisco 49ers vs. Philadelphia Eagles Prediction

This feels like the high point here. Gotta buy this back after early money poured in on Philly fading the Niners defense.

I just don’t know what this Philly offense has proven to where you can be confident getting margin here. The negative perception of Philly has dwindled since the Chargers game after playing a bunch of nobodies and having that lucky win vs Buffalo.

Meanwhile, the perception of this Niners team has become negative after one bad performance without Trent Williams and Ricky Pearsall, who seem hopeful to return in this spot.

I will gladly take Shanahan and co. at this number in a game where the worst case, there will always be hope for a backdoor.

San Francisco 49ers vs. Philadelphia Eagles Prediction: 49ers +4.5 (-110)

(Pick from Anders)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

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What Time is the San Francisco 49ers vs. Philadelphia Eagles Game?

The San Francisco 49ers vs. Philadelphia Eagles game is at 4:30 PM ET on Sunday, January 11th.

Where is the San Francisco 49ers vs. Philadelphia Eagles Game Being Played?

This game will be played at Lincoln Financial Field in Philadelphia, PA.

How Can I Watch San Francisco vs. Philadelphia?

You can watch San Francisco 49ers vs. Philadelphia Eagles on FOX.

Can the 49ers Beat the Eagles?

Absolutely, the 49ers are slight underdogs, so the oddsmakers think this will be a tight one in Philly.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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