NFL Odds Week 1: 49ers vs Steelers Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

The first Sunday of the 2023 NFL season is upon us, and that means it's time for NFL odds for Week 1: 49ers vs Steelers lines, spreads and betting trends.

The 49ers and Steelers meet at Acrisure Stadium in Pittsburgh on Sunday, September 10 at 1:00 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for the Week 1 game between the 49ers and Steelers: the opening lines, spreads, betting trends and more. Check back regularly for updates.

San Francisco 49ers vs Pittsburgh Steelers Odds

• Opening point spread: 49ers -3
• Opening moneyline: 49ers -140/Steelers +120
• Opening total: Over/Under 41 points scored
• Time: 1 p.m. ET Sunday, Sept. 10 (FOX)

UPDATE 10 A.M. ET SUNDAY: Pittsburgh continues to be a trendy underdog at BetMGM. Three hours before kickoff, the home 'dog Steelers are netting 60% of spread tickets/69% of spread dollars.

Further, moneyline bettors like the Pittsburgh. Ticket count is almost 3/1 and money almost 4/1 on the Steelers. And if you want to bet the Steelers on the moneyline at bet365, make sure to use our bet365 bonus code!

San Fran opened as a 3-point road chalk, briefly got as low as -1.5 Thursday and is now at -2.5. The moneyline is at Niners -130/Steelers +110. The total is at 41.5 and drawing two-way play.

UPDATE 4 P.M. ET FRIDAY: San Francisco opened as a 3-point chalk back in May at BetMGM nationally. The line toggled from -3 to -2.5 a couple of times, the latest on Aug. 28. Then on Thursday, it briefly got as low as Niners -1.5, before rebounding to -2, where it sits now.

Pittsburgh is definitely a trendy 'dog with early bettors, taking 62% of spread tickets/77% of spread money. Further, early moneyline action is on the Steelers, with tickets and cash in the 4/1 range at BetMGM. The moneyline is currently 49ers -130/Steelers +110, after opening -155/+130.

The total opened at 41.5, receded to 40.5 during the summer and climbed to 42 by Wednesday afternoon. It's now at 41.5 on two-way play, with tickets almost even and 56% of money on the Under.

UPDATE 10 P.M. ET FRIDAY, SEPT 1: BetMGM Nevada pegged San Fran a 3-point road favorite back in May, and the line is now Niners -2.5.

"Tickets are really close, a handful more on the 49ers. Money is approximately 2/1 on the Steelers. Sharp play on Steelers +3," Shelton said.

UPDATE 1:30 P.M. ET MONDAY, AUG. 28: San Francisco reached the last two NFC Championship Games, but couldn't convert either into a Super Bowl bid. The Niners (15-5 SU, 13-7 ATS in 2022-23) saw QB Brock Purdy (elbow) exit early in last season's NFC final and subsequently got drilled at Philadelphia 31-7 as 2.5-point 'dogs.

Purdy had offseason elbow surgery and will be the 49ers' starter.

Meanwhile, Pittsburgh (9-8 SU, 10-6-1 ATS) kept alive coach Mike Tomlin's 16-year run of never having a losing record. But barely so. The Steelers went 6-1 SU and ATS in their last seven games, winning and cashing the last four, but didn't make the playoffs.

San Fran toggled between -3 and -2.5 a couple times this summer in The SuperBook's NFL odds Week 1 market. The latest move was on Aug. 20, from -3 (even) to -2.5 flat. The total went to 41.5 shortly after opening in May, then returned to 41 in mid-July.

""We took some sharp action on the home 'dog Steelers +3, moving us to 2.5," Degnon said. "I think we will see some public money come in on the 49ers."

While The SuperBook's spread/total opened back on May 11, the moneyline just opened today, hence no movement so far.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Check out the North Carolina Sportsbooks just before they launch legal online sports betting.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson