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Featured Last Updated Sep 25 2025, 1:11 PM

NFL: Panthers vs. Patriots, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Panthers vs. Patriots, Prediction, Odds, Best Bet

Featured Image Credit: Paul Rutherford via Imagn Images

CAR @ NE Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Carolina Panthers 257 Panthers
+3.5 -105 +3 -105 + +2.5 +105 + +3.5 -122 + +3.5 -118 + +3.5 -125 + +3.5 -110 + +3.5 -125 +3.5 -124 + +3.5 -115 +3.5 -124 +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 -3 -115 + -2.5 -125 + -3.5 +102 + -3.5 -104 + -3.5 -105 + -3.5 -110 + -3.5 +105 -3.5 -103 + -3.5 -105 -3.5 -103 -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o21.5 -110 + N/A o21.5 -110 + o21.5 -112 N/A o21.5 -110 + o22.5 even o21.5 -112 + o21.5 -110 o21.5 -112 o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u21.5 -110 + N/A u21.5 -110 + u21.5 -110 N/A u21.5 -110 + u22.5 -120 u21.5 -112 + u21.5 -110 u21.5 -112 u42.5 -105  
Carolina Panthers 257 Panthers
+145 +155 + N/A +154 + +155 + +170 + +172 + +160 +160 + N/A +160 +185  
New England Patriots 258 Patriots
-175 -185 + N/A -185 + -197 + -240 + -215 + -190 -200 + N/A -200 -225  
Carolina Panthers 257 Panthers
+3.5 -105 +0.5 -130 + +0.5 -145 + +0.5 -130 + N/A N/A +1.5 -126 + +1.5 -150 +1.5 -137 + +0.5 -120 +1.5 -137 +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 -0.5 +110 + -0.5 +110 + -0.5 +110 + N/A N/A -1.5 +102 + -1.5 +110 -1.5 +110 + -0.5 even -1.5 +110 -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o7.5 +105 + N/A o7.5 +110 + N/A N/A o7.5 +104 + o8.5 even o7.5 even + o7.5 +105 o7.5 even o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u7.5 -125 + N/A u7.5 -130 + N/A N/A u7.5 -128 + u8.5 -135 u7.5 -125 + u7.5 -125 u7.5 -125 u42.5 -105  
Carolina Panthers 257 Panthers
+145 +130 + N/A +124 + +140 + N/A +146 + +120 +135 + N/A +135 +185  
New England Patriots 258 Patriots
-175 -155 + N/A -148 + -170 + N/A -180 + -160 -175 + N/A -175 -225  
Carolina Panthers 257 Panthers
+3.5 -105 +3 -110 + N/A +2.5 even + +2.5 -105 + N/A +2.5 -110 + N/A +2.5 -103 + N/A +2.5 -103 +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 -3 -110 + N/A -2.5 -120 + -2.5 -115 + N/A -2.5 -110 + N/A -2.5 -121 + N/A -2.5 -121 -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o21 -110 + N/A o20.5 -110 + o20.5 -105 + N/A o20.5 -110 + N/A o20.5 -109 + o20.5 -110 o20.5 -109 o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u21 -110 + N/A u20.5 -110 + u20.5 -115 + N/A u20.5 -110 + N/A u20.5 -114 + u20.5 -120 u20.5 -114 u42.5 -105  
Carolina Panthers 257 Panthers
+145 +135 + N/A +154 + N/A N/A +146 + N/A +145 + N/A +145 +185  
New England Patriots 258 Patriots
-175 -160 + N/A -185 + N/A N/A -172 + N/A -182 + N/A -182 -225  
Carolina Panthers 257 Panthers
+3.5 -105 N/A N/A +2.5 -110 + N/A N/A +2.5 -112 + N/A N/A +2.5 -115 N/A +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 N/A N/A -2.5 -110 + N/A N/A -2.5 -110 + N/A N/A -2.5 -115 N/A -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o12.5 -110 + N/A o13.5 +114 + N/A N/A o13.5 -102 + N/A N/A o13.5 +105 N/A o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u12.5 -110 + N/A u13.5 -135 + N/A N/A u13.5 -118 + N/A N/A u13.5 -135 N/A u42.5 -105  
Carolina Panthers 257 Panthers
+145 +165 + N/A +142 + N/A N/A +142 + N/A N/A N/A N/A +185  
New England Patriots 258 Patriots
-175 -200 + N/A -170 + N/A N/A -176 + N/A N/A N/A N/A -225  
Carolina Panthers 257 Panthers
+3.5 -105 N/A N/A +0.5 -122 + N/A N/A +1.5 -138 + N/A N/A +0.5 -130 N/A +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 N/A N/A -0.5 +102 + N/A N/A -1.5 +114 + N/A N/A -0.5 even N/A -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o9.5 -110 + N/A o8.5 -108 + N/A N/A o8.5 -108 + N/A N/A o7.5 -115 N/A o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u9.5 -110 + N/A u8.5 -112 + N/A N/A u8.5 -112 + N/A N/A u7.5 -115 N/A u42.5 -105  
Carolina Panthers 257 Panthers
+145 +140 + N/A +136 + N/A N/A +130 + N/A N/A N/A N/A +185  
New England Patriots 258 Patriots
-175 -165 + N/A -162 + N/A N/A -160 + N/A N/A N/A N/A -225  
Carolina Panthers 257 Panthers
+3.5 -105 +0.5 -120 + N/A +1.5 -115 + N/A N/A +1.5 -130 + N/A N/A +2.5 -120 N/A +5.5 -112  
New England Patriots 258 Patriots
-3.5 -115 -0.5 even + N/A -1.5 -105 + N/A N/A -1.5 +106 + N/A N/A -2.5 -110 N/A -5.5 -108  
Carolina Panthers 257 Panthers
o45.5 -110 o12.5 -110 + N/A o11.5 -112 + N/A N/A o11.5 -110 + N/A N/A o10.5 -115 N/A o42.5 -115  
New England Patriots 258 Patriots
u45.5 -110 u12.5 -110 + N/A u11.5 -108 + N/A N/A u11.5 -110 + N/A N/A u10.5 -115 N/A u42.5 -105  
Carolina Panthers 257 Panthers
+145 +120 + N/A +136 + N/A N/A +126 + N/A N/A N/A N/A +185  
New England Patriots 258 Patriots
-175 -140 + N/A -162 + N/A N/A -154 + N/A N/A N/A N/A -225  

The Panthers will take on the Patriots in this week's NFL action. Kickoff is set for 1:00 p.m. EDT at Gillette Stadium in Foxborough, Mass. The game will be broadcast live on FOX. Here's everything you need to know about Panthers vs. Patriots odds, the latest NFL spreads, NFL over/unders and more.

The Patriots opened as a -5.5 point favorite over Panthers. The total is set at over/under 43.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Carolina Panthers vs. New England Patriots Best Bet

The strangest game of the day on Sunday had to be the Panthers' trouncing of a strong Falcons team — but to make it stranger, it featured just 224 yards of total offense out of Carolina.

Chuba Hubbard looked strong, and the Panthers' offensive line protected Bryce Young, but I don't think there's some magical transformation going on here. This is still a bad line that was granted an excellent matchup against a Falcons pass rush that is very weak, and now they'll have to combat a Patriots defensive front that ranks top 10 in both pass rush and run stop win rates.

New England hasn't recorded a ton of pressures, but that should change in time — and a matchup with an awful offensive line  down two players already is a good start.

Mix in the fact that Drake Maye is coming off a pretty solid game against one of the best pass rushes around, too, and I think you've got enough here to take New England.

Carolina's lone strength on defense is getting to the quarterback, and on offense I'm not sure it has one — at least in this matchup.

Panthers vs. Patriots Best Bet: Patriots -5.5

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Carolina Panthers vs. New England Patriots Game?

The Carolina Panthers vs. New England Patriots game is at 1:00 PM ET on Sunday, September 28th.

Where is the Carolina Panthers vs. New England Patriots Being Played?

This game will be played at Gillette Stadium in Foxborough, Massachusetts.

How Can I Watch Panthers vs. Patriots?

You can watch Panthers vs. Patriots on FOX.

Can the Panthers Beat the Patriots?

Yes, after coming off their first victory of the year, the Panthers will look to ride that momentum into Foxborough against New England.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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