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Featured Last Updated Sep 18 2025, 1:14 PM

New Orleans Saints vs. Seattle Seahawks Week 3 Prediction: Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
New Orleans Saints vs. Seattle Seahawks Week 3 Prediction: Odds, Best Bet

New Orleans Saints vs. Seattle Seahawks Odds, NFL Week 3

Image Credit: Brett Davis-Imagn Images

NO @ SEA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
New Orleans Saints 471 Saints
+6.5 -105 +3.5 even + +3.5 even + +3.5 -102 + +3.5 -101 + N/A +4.5 -115 + +3.5 even +4.5 -121 + +4.5 -121 +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 -3.5 -120 + -3.5 -120 + -3.5 -118 + -3.5 -118 + N/A -4.5 -105 + -3.5 -120 -4.5 -105 + -4.5 -105 -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o20.5 -115 + N/A o21.5 -108 + o20.5 -115 + N/A o20.5 -110 + o20.5 -110 o20.5 -110 + o20.5 -110 o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u20.5 -105 + N/A u21.5 -112 + u20.5 -105 + N/A u20.5 -110 + u20.5 -110 u20.5 -113 + u20.5 -113 u41.5 -110  
New Orleans Saints 471 Saints
+210 +195 + N/A +185 + +196 + N/A +215 + +190 +220 + +220 +280  
Seattle Seahawks 472 Seahawks
-258 -240 + N/A -225 + -240 + N/A -280 + -240 -286 + -286 -375  
New Orleans Saints 471 Saints
+6.5 -105 +0.5 -125 + +0.5 -125 + +0.5 -125 + +0.5 -130 + N/A +1.5 -110 + +1.5 -120 +1.5 -118 + +1.5 -118 +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 -0.5 +105 + -0.5 -102 + -0.5 +105 + -0.5 even + N/A -1.5 -110 + -1.5 -110 -1.5 -106 + -1.5 -106 -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o7.5 +115 + N/A o7.5 +114 + o7.5 +105 + N/A o7.5 +116 + o8.5 -110 o7.5 +102 + o7.5 +102 o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u7.5 -135 + N/A u7.5 -135 + u7.5 -135 + N/A u7.5 -140 + u8.5 -120 u7.5 -127 + u7.5 -127 u41.5 -110  
New Orleans Saints 471 Saints
+210 +145 + N/A +140 + +155 + N/A +172 + +160 +163 + +163 +280  
Seattle Seahawks 472 Seahawks
-258 -170 + N/A -166 + -190 + N/A -215 + -210 -210 + -210 -375  
New Orleans Saints 471 Saints
+6.5 -105 N/A N/A +2.5 +110 + N/A N/A +3.5 -134 + N/A N/A N/A +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 N/A N/A -2.5 -130 + N/A N/A -3.5 +110 + N/A N/A N/A -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o13 -105 + N/A o13.5 +105 + N/A N/A o13.5 +112 + N/A N/A N/A o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u13 -115 + N/A u13.5 -125 + N/A N/A u13.5 -136 + N/A N/A N/A u41.5 -110  
New Orleans Saints 471 Saints
+210 +200 + N/A +170 + N/A N/A +184 + N/A N/A N/A +280  
Seattle Seahawks 472 Seahawks
-258 -245 + N/A -205 + N/A N/A -230 + N/A N/A N/A -375  
New Orleans Saints 471 Saints
+6.5 -105 N/A N/A +2.5 -110 + N/A N/A +1.5 -110 + N/A N/A N/A +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 N/A N/A -2.5 -110 + N/A N/A -1.5 -110 + N/A N/A N/A -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o7.5 -105 + N/A o7.5 -108 + N/A N/A o7.5 -104 + N/A N/A N/A o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u7.5 -115 + N/A u7.5 -112 + N/A N/A u7.5 -118 + N/A N/A N/A u41.5 -110  
New Orleans Saints 471 Saints
+210 +180 + N/A +170 + N/A N/A +164 + N/A N/A N/A +280  
Seattle Seahawks 472 Seahawks
-258 -220 + N/A -198 + N/A N/A -205 + N/A N/A N/A -375  
New Orleans Saints 471 Saints
+6.5 -105 +1 -110 + N/A +2.5 -105 + N/A N/A +2.5 -110 + N/A N/A N/A +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 -1 -110 + N/A -2.5 -115 + N/A N/A -2.5 -110 + N/A N/A N/A -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o10.5 even + N/A o10.5 -105 + N/A N/A o10.5 +104 + N/A N/A N/A o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u10.5 -120 + N/A u10.5 -115 + N/A N/A u10.5 -126 + N/A N/A N/A u41.5 -110  
New Orleans Saints 471 Saints
+210 +150 + N/A +170 + N/A N/A +156 + N/A N/A N/A +280  
Seattle Seahawks 472 Seahawks
-258 -180 + N/A -205 + N/A N/A -194 + N/A N/A N/A -375  
New Orleans Saints 471 Saints
+6.5 -105 +3.5 -110 + N/A N/A +4.5 -120 + N/A +3.5 -110 + N/A +3.5 -106 + +3.5 -106 +7 -105  
Seattle Seahawks 472 Seahawks
-6.5 -115 -3.5 -110 + N/A N/A -4.5 even + N/A -3.5 -110 + N/A -3.5 -118 + -3.5 -118 -7 -115  
New Orleans Saints 471 Saints
o43.5 -110 o19.5 -120 + N/A N/A o20.5 +105 + N/A o19.5 -120 + N/A o20.5 -104 + o20.5 -104 o41.5 -110  
Seattle Seahawks 472 Seahawks
u43.5 -110 u19.5 even + N/A N/A u20.5 -125 + N/A u19.5 -100 + N/A u20.5 -121 + u20.5 -121 u41.5 -110  
New Orleans Saints 471 Saints
+210 +195 + N/A N/A N/A N/A +196 + N/A +200 + +200 +280  
Seattle Seahawks 472 Seahawks
-258 -240 + N/A N/A N/A N/A -235 + N/A -265 + -265 -375  

The Saints will take on the Seahawks in this week's NFL action. Kickoff is set for 4:05 p.m. EDT at Lumen Field in Seattle, Wash. The game will be broadcast live on CBS. Here's everything you need to know about Saints vs. Seahawks odds, the latest NFL spreads, NFL over/unders and more.

The Seahawks opened as a -7.5 point favorite over Saints. The total is set at over/under 41.5 total points scored by both teams combined.

Be sure to check out the latest NFL Odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/18/25

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New Orleans Saints vs. Seattle Seahawks Best Bet

Great number here on Walker this week and one I would jump on early, as I'm fully expecting this number to be higher as we get closer to Sunday. This Seattle backfield has been balanced to open the year, with both Walker and Zach Charbonnet seeing significant work. Walker looked like the much better back last week against the Steelers, and Charbonnet is dealing with a foot injury and has yet to practice this week.

If Charbonnet is out, this number likely jumps to 65.5 or higher and even if he plays, the Seahawks are a run-first team and big 7.5-point home favorites against the Saints, so there should be plenty of work to go around. New Orleans allowed the 6th most rushing yards to running backs in 2024, and they reside in the bottom 12 to open up 2025 at 91.5 rushing yards per game allowed to running backs. I will be laddering this one all the way up to 100+ rushing yards for some nice plus odds payouts as well.

New Orleans Saints vs. Seattle Seahawks Best Bet: Kenneth Walker o58.5 Rushing Yards (-115)

(Pick via Chris Prince)


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What Time is the New Orleans Saints vs. Seattle Seahawks Game?

The New Orleans Saints vs. Seattle Seahawks play at 4:05 PM ET on Sunday, September 21st.

Where is the New Orleans Saints vs. Seattle Seahawks Game Being Played?

This game is going to be played at Lumen Field in Seattle, WA.

How Can I Watch the New Orleans Saints vs. Seattle Seahawks?

You can watch New Orleans Saints vs. Seattle Seahawks on CBS.

Can The Saints Beat The Seahawks?

The Saints are 7 points underdogs vs. the Seahawks. Anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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