Los Angeles Rams vs. New York Giants Predictions, Odds, Picks
The Los Angeles Rams (4-1) hit the road to battle the New York Giants (1-4) at MetLife Stadium in East Rutherford, N.J. for a Week 6 battle. Kickoff is scheduled for 1:00 p.m. ET, with the game nationally televised on FOX.
Score Prediction
Rams 29, Giants 13
Best Bets
Rams -9.5
Under
Los Angeles Rams vs. New York Giants Predictions
The Rams were humbled by the first-place Arizona Cardinals in an NFC West showdown back in Week 4. With a quick turnaround to play in front of a hostile crowd, the Rams rebounded with a 26-17 victory to cover a 2.5-point number at Lumen Field in Seattle. The only surprise in that game was the fact the UNDER cashed for the first time in five outings after four straight OVERs to start the season.
The Giants were dropped 44-20 in Dallas last weekend, but the loss actually wasn’t the worst part of the whole game. It was injuries, and they were numerous. QB Daniel Jones left with a concussion, RBSaquon Barkley rolled his ankle by inadvertently stepping on a defense and there were other key injuries as well. WR Kadarius Toney, who was stepping in for the absent WRs Sterling Shepard and Darius Slayton, turned an ankle. The latter two receivers are question marks due to hamstring injuries. WRKenny Golladay also suffered a knee ailment, tried to return, and just couldn’t finish up.
While Jones remains in the concussion protocol, was limited to light work Wednesday. It is likely QBMike Glennon will start against the Rams, with rookie QB Brian Lewerke perhaps as the backup. Glennon could at least have Shepard back, as he practiced Wednesday after missing the past two games.
Los Angeles Rams vs. New York Giants Betting Odds
Los Angeles Rams vs. New York Giants Betting Resources
- Matchup: NFC West vs. NFC East
- Date: Sunday, October 17, 2021
- Venue: MetLife Stadium
- Location: East Rutherford, New Jersey
- TV-Time: FOX - 1:00 p.m. ET
Los Angeles Rams Betting Analysis
Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)
- SU: 4-1
- ATS: 3-2
- O/U: 4-1
- ATS - Home: 2-1
- ATS - Away: 1-1
The Rams are in much better shape on the injury report, and QB Matthew Stafford should excel against the G-Men. The biggest obstacle for Stafford and the Rams might be the cross-country travel. The last lengthy road trip, back in Week 2 to Indianapolis, resulted in a 27-24 win over the Colts, although Indy covered as four-point underdogs.
The Rams are 24-9-1 ATS in the past 34 against NFC foes, although they’re a dismal 0-4 ATS in the past four against teams with a losing record. While the latter is a little worrisome, feel better about a wager on the road team laying near double digits. They’ll be playing a backup QB, likely a backup RB and a patchwork WR corps. That’s great news for the visitors.
New York Giants Betting Analysis
Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)
- SU: 1-4
- ATS: 2-3
- O/U: 3-2
- ATS - Home: 0-2
- ATS - Away: 2-1
The Giants, as mentioned several times above, are banged up, perhaps worse than any other team. Several key positions, especially the skill positions, will be depleted, and they also lost CB Rodarius Williams to a season-ending knee injury, too. S Jabrill Peppers is dealing with a hamstring injury, and CB
Logan Ryan exited with a hip ailment, too. Things are not looking good for Los Angeles.
Even when healthy, the G-Men haven’t been great against the number. New York is just 6-19-1 ATS in the past 26 games at home, while going just 4-15 ATS in the past 19 games as a home underdog. They’re also 0-4 ATS in the past four at home against teams with a winning road record.If you’re a total bettor, you have to love the Giants. The UNDER is 10-3 in the past 13 games overall, while going a perfect 6-0 in the past six at home. That includes 5-0 as a home underdog.

The Los Angeles Rams have gone OVER the point total in six of their last seven games. (AP)
Inside the Stats - Los Angeles Rams
- Record: 4-1
- Division Standing: 2nd - NFC West
- Points Scored: 141
- Points Allowed: 116
- PS/G: 28.2 (8th)
- PA/G: 23.2 (12th)
Inside the Stats - New York Giants
- Record: 1-4
- Division Standing: 4th - NFC East
- Points Scored: 103
- Points Allowed: 139
- PS/G: 20.6 (23rd)
- PA/G: 27.8 (26th)
Key Players to Watch
- LAR: Matthew Stafford - QB (117/172, 1,587 yards, 12 TD, 3 INT)
- LAR: Cooper Kupp - WR (37 catches, 523 yards, 5 TD)
- NYG: Mike Glennon - QB (16/25, 196 yards, TD, 2 INT)
- NYG: Kadarius Toney - WR (20 catches, 281 yards)
Los Angeles Rams vs. New York Giants Betting Conclusion
Laying double digits, or near double digits, can be a risky proposition for a road team in the NFL. However, the Rams are a Super Bowl contender, and the Giants struggle even when they’re healthy. But the home side is very banged up, and while Glennon did a pretty decent job last week, most of his success came in garbage time with the game well out of hand.
The Rams pass rush is stout, and it’s not going to end well for the home side. The Giants defense will have to have all hands on deck, but they might not even be able to help out much with some injuries in the back end. That’s not good news, especially facing a Rams side which had a couple of extra days to prepare and rest after last playing Thursday in Week 5.
Los Angeles Rams vs. New York Giants Betting Trends
- New York has failed to cover the spread in six of its last nine games.
- New York has gone UNDER the point total in nine of its last 12 games.
- Los Angeles has gone OVER the point total in six of its last seven games.
- Los Angeles has won five of its last seven road games.
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